2-(4-Aminobutyl)anthracene-9,10-dione | 195143-15-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 2-(4-Aminobutyl)anthracene-9,10-dione
• CAS: 195143-15-8
• 化学式: C₁₈H₁₇NO₂
• 分子量: 279.338
• InChiKey: GPFCKJXOTOOZIK-UHFFFAOYSA-N

物化性质

• 沸点：
  479.3±44.0 °C(Predicted)
• 密度：
  1.222±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-Aminobutyl)anthracene-9,10-dione 在 四丁基氟化铵 、 1-羟基苯并三唑 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 溶剂黄146 、 三乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 35.0h， 生成
  参考文献：
  名称：

  Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA- complements

  摘要：

  The synthesis of the amide dimers 3-5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures (T-m's) of the corresponding duplexes with RNA- and DNA- complements and a summary of molecular modeling studies. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00318-1
• 作为产物：
  描述：

  2-溴甲基蒽醌 在 sodium azide 、 偶氮二异丁腈 、 氢溴酸 、 三正丁基氢锡 、 过氧化苯甲酰 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 92.0h， 生成 2-(4-Aminobutyl)anthracene-9,10-dione
  参考文献：
  名称：

  Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA- complements

  摘要：

  The synthesis of the amide dimers 3-5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures (T-m's) of the corresponding duplexes with RNA- and DNA- complements and a summary of molecular modeling studies. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00318-1

文献信息

• Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA- complements
  作者：Alain De Mesmaeker、Sebastian Wendeborn、Chantal Jouanno、Valérie Fritsch、Romain M. Wolf

  DOI：10.1016/s0960-894x(97)00318-1

  日期：1997.7

  The synthesis of the amide dimers 3-5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures (T-m's) of the corresponding duplexes with RNA- and DNA- complements and a summary of molecular modeling studies. (C) 1997 Elsevier Science Ltd.