Ethyl 3-[[3-[(3-ethoxy-3-oxopropyl)carbamoyl]-5-nitrobenzoyl]amino]propanoate | 905858-82-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ethyl 3-[[3-[(3-ethoxy-3-oxopropyl)carbamoyl]-5-nitrobenzoyl]amino]propanoate
• CAS: 905858-82-4
• 化学式: C₁₈H₂₃N₃O₈
• 分子量: 409.396
• InChiKey: YEASFIPQAGSVJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  29
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  157
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Ethyl 3-[[3-[(3-ethoxy-3-oxopropyl)carbamoyl]-5-nitrobenzoyl]amino]propanoate 在 T-1 Raney Ni sodium hydroxide 、 氢气 、 三乙胺 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 20.0 ℃ 、344.74 kPa 条件下， 反应 3.0h， 生成 3-[[[3-[[[3,5-bis[N-[3,5-bis[N-(2-carboxyethyl)-C-hydroxycarbonimidoyl]phenyl]-C-hydroxycarbonimidoyl]phenyl]-hydroxymethylidene]amino]-5-[N-(2-carboxyethyl)-C-hydroxycarbonimidoyl]phenyl]-hydroxymethylidene]amino]propanoic acid
  参考文献：
  名称：

  Iron Binding Dendrimers:  A Novel Approach for the Treatment of Haemochromatosis

  摘要：

  A range of iron binding dendrimers terminated with hexadentate ligands formed from hydroxypyridinone, hydroxypyranone, and catechol moieties have been synthesized in order to investigate their potential as clinically useful iron(III)-selective chelators capable of removing dietary iron from the gastrointestinal tract and preventing the development of iron overload typical of haemochromatosis and thalassaemia intermedia. The iron chelating abilities of these molecules have been characterized by MALDI-TOF mass spectrometry and UV spectrometry. Hydroxypyridinone-terminated dendrimers were found to possess a high affinity and selectivity for iron(III). A hydroxypyridinone-based dendrimer was demonstrated to be highly efficient at reducing the absorption of iron(III) in rat intestine. This family of dendrimers may find an application in the treatment of iron overload.

  DOI：

  10.1021/jm0600949
• 作为产物：
  描述：

  5-硝基异酞酸 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 Ethyl 3-[[3-[(3-ethoxy-3-oxopropyl)carbamoyl]-5-nitrobenzoyl]amino]propanoate
  参考文献：
  名称：

  Iron Binding Dendrimers:  A Novel Approach for the Treatment of Haemochromatosis

  摘要：

  A range of iron binding dendrimers terminated with hexadentate ligands formed from hydroxypyridinone, hydroxypyranone, and catechol moieties have been synthesized in order to investigate their potential as clinically useful iron(III)-selective chelators capable of removing dietary iron from the gastrointestinal tract and preventing the development of iron overload typical of haemochromatosis and thalassaemia intermedia. The iron chelating abilities of these molecules have been characterized by MALDI-TOF mass spectrometry and UV spectrometry. Hydroxypyridinone-terminated dendrimers were found to possess a high affinity and selectivity for iron(III). A hydroxypyridinone-based dendrimer was demonstrated to be highly efficient at reducing the absorption of iron(III) in rat intestine. This family of dendrimers may find an application in the treatment of iron overload.

  DOI：

  10.1021/jm0600949

文献信息

• Iron Binding Dendrimers:  A Novel Approach for the Treatment of Haemochromatosis
  作者：Tao Zhou、Hendrik Neubert、Ding Yong Liu、Zu Dong Liu、Yong Min Ma、Xiao Le Kong、Wei Luo、Sykes Mark、Robert C. Hider

  DOI：10.1021/jm0600949

  日期：2006.7.1

  A range of iron binding dendrimers terminated with hexadentate ligands formed from hydroxypyridinone, hydroxypyranone, and catechol moieties have been synthesized in order to investigate their potential as clinically useful iron(III)-selective chelators capable of removing dietary iron from the gastrointestinal tract and preventing the development of iron overload typical of haemochromatosis and thalassaemia intermedia. The iron chelating abilities of these molecules have been characterized by MALDI-TOF mass spectrometry and UV spectrometry. Hydroxypyridinone-terminated dendrimers were found to possess a high affinity and selectivity for iron(III). A hydroxypyridinone-based dendrimer was demonstrated to be highly efficient at reducing the absorption of iron(III) in rat intestine. This family of dendrimers may find an application in the treatment of iron overload.