N-叔丁基-2-(1H-吲哚-2-基)-乙酰胺 | 104196-92-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: N-叔丁基-2-(1H-吲哚-2-基)-乙酰胺
• 中文别名: 1H-吲哚-2-乙酰胺,N-(1,1-二甲基乙基)-
• 英文名称: N-(tert-butyl)-2-(1H-indol-2-yl)acetamide
• 英文别名: N-tert-butyl-2-(1H-indol-2-yl)acetamide
• CAS: 104196-92-1
• 化学式: C₁₄H₁₈N₂O
• 分子量: 230.31
• InChiKey: FOCZMLVCBNVUOM-UHFFFAOYSA-N

物化性质

• 熔点：
  165-165.5 °C
• 沸点：
  471.0±28.0 °C(Predicted)
• 密度：
  1.114±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  44.9
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Lithium; 2-(tert-butylcarbamoyl-methyl)-indole-1-carboxylate 以 四氢呋喃 、 正戊烷 为溶剂， 反应 10.0h， 生成 N-叔丁基-2-(1H-吲哚-2-基)-乙酰胺
  参考文献：
  名称：

  Carbon dioxide: a reagent for simultaneous protection of nucleophilic centers and the activation of alternative locations to electrophilic attack. V. Activation of the 2-alkyl group of a 2-alkylindole toward proton loss and subsequent electrophilic substitution

  摘要：

  DOI：

  10.1021/ja00281a061

文献信息

• Palladium-Catalyzed Synthesis of Free-NH Indole 2-Acetamides and Derivatives from Ethyl 3-(o-Trifluoroacetamidoaryl)-1-propargylic Carbonates
  作者：Sandro Cacchi、Giancarlo Fabrizi、Eleonora Filisti

  DOI：10.1055/s-0029-1217377

  日期：2009.7

  The reaction of ethyl 3-(o-trifluoroacetamidoaryl)-1-propargylic carbonates with primary or secondary amines in the presence of Pd 2 (dba) 3 , dppf, and carbon monoxide in THF at 80 °C provides ready access to free-NH indole 2-acetamides. The reaction can be applied to the synthesis of free-NH indole 2-acetic acid methyl esters.

  在 Pd 2 (dba) 3 、dppf 和一氧化碳的存在下，在 80 °C 的 THF 中，3-(o-三氟乙酰氨基芳基)-1-炔丙基碳酸酯与伯胺或仲胺的反应提供了容易获得游离 NH吲哚2-乙酰胺。该反应可用于合成游离NH吲哚2-乙酸甲酯。
• CoFe2O4@SiO2-NH-βCD-BF3 as a supramolecular nanocomposite: Synthesis, characterization and catalytic activity
  作者：Hosein Hamadi、Zohreh Zanjani、Mahtab Yadollahi

  DOI：10.1016/j.poly.2019.114219

  日期：2020.1

  This manuscript describes synthesis of BF3-functionlized beta-cylcodextrine grafted magnetic CoFe2O4 nanaoparticles as a hybrid magnetic nano-composite (CoFe2O4@SiO2-NH-OCD-BF3). The CoFe2O4@SiO2NH-beta CD-BF3 was fabricated by grafting of 6-O-toluenesulfonyl cyclodextrin (6-Ts-beta CD) to 3-aminopropyl triethoxysilane coated magnetic CoFe2O4@SiO2 nanoparticles followed by combination with BF3. The CoFe2O4@SiO2-NH-beta CD-BF(3)was characterized by FT-IR, TGA, VSM and SEM techniques. The feasibility of using CoFe2O4@SiO2-NH-beta CD-BF3 as a magnetically recoverable catalyst was confirmed in the modified-Ritter reaction. The result showed that this novel nano-composite could serve as an efficient nanoreactor bearing super-acidic sites formed by immobilized BF3 and reuse at least for 6 times without loss in activity. (C) 2019 Elsevier Ltd. All rights reserved.
• Inagaki, Satoshi; Nishizawa, Yoshihiro; Sugiura, Takashi, Journal of the Chemical Society. Perkin transactions I, 1990, # 1, p. 179 - 180
  作者：Inagaki, Satoshi、Nishizawa, Yoshihiro、Sugiura, Takashi、Ishihara, Hideharu

  DOI：——

  日期：——
• INAGAKI, SATOSHI;NISHIZAWA, YOSHIHIRO;SUGIURA, TAKASHI;ISHIHARA, HIDEHARU, J. CHEM. SOC. PERKIN TRANS. PT 1,(1990) N, C. 179-180
  作者：INAGAKI, SATOSHI、NISHIZAWA, YOSHIHIRO、SUGIURA, TAKASHI、ISHIHARA, HIDEHARU

  DOI：——

  日期：——
• KATRITZKY A. R.; AKUTAGAWA KUNIHIKO, J. AMER. CHEM. SOC., 108,(1986) N 21, 6808-6809
  作者：KATRITZKY A. R.、 AKUTAGAWA KUNIHIKO

  DOI：——

  日期：——