2-叠氮基蒽醌 | 49545-73-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 2-叠氮基蒽醌
• 英文名称: 2-Azido-anthrachinon
• 英文别名: 2-azidoanthraquinone；2-azidoanthracene-9,10-dione
• CAS: 49545-73-5
• 化学式: C₁₄H₇N₃O₂
• 分子量: 249.228
• InChiKey: HCRMBUAINHNLEN-UHFFFAOYSA-N

物化性质

• 熔点：
  160 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-叠氮基蒽醌 在 硫酸 作用下， 生成 2-氨基-1-羟基蒽醌
  参考文献：
  名称：

  Brass; Ziegler, Chemische Berichte, 1925, vol. 58, p. 762

  摘要：

  DOI：
• 作为产物：
  描述：

  在 sodium azide 作用下， 以 水 为溶剂， 反应 0.17h， 生成 2-叠氮基蒽醌
  参考文献：
  名称：

  A fast and efficient method for the preparation of aryl azides using stable aryl diazonium silica sulfates under mild conditions

  摘要：

  An efficient, fast, and straightforward procedure for the synthesis of aromatic azides using aryl diazonium silica sulfates and sodium azide at room temperature under mild conditions is described. The use of inexpensive materials, simple and clean work-Lip, short reaction times and good yields are advantages of this method. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.05.049

文献信息

• CHEMOSELECTIVE REDUCTION OF AZIDES WITH SODIUM SULFIDE HYDRATE UNDER SOLVENT FREE CONDITIONS
  作者：Foad Kazemi、Ali Reza Kiasat、Sohyl Sayyahi

  DOI：10.1080/10426500490466544

  日期：2004.9

  Sodium sulfide hydrate has been employed for an efficient reduction of a variety of azides to the primary amines in good-to-excellent yields under solvent-free system and without perturbing many active functionalities such as ether, carbonyl, sulfonyl, and nitro.

  硫化钠水合物已被用于在无溶剂系统下以良好到优异的产率将各种叠氮化物有效还原为伯胺，并且不会干扰许多活性官能团，例如醚、羰基、磺酰基和硝基。
• Synthesis and complexation study of new ExTTF-based hosts for fullerenes
  作者：Hassan Iden、Frédéric-Georges Fontaine、Jean-Francois Morin

  DOI：10.1039/c3ob42477d

  日期：——

  synthesized for supramolecular binding study of fullerenes C60 and C70. Binding constants for C60 in chlorobenzene, toluene, toluene–CH2Cl2 and CS2 have been calculated for different hosts and a direct structure–affinity relationship has been established. As predicted, receptors with two exTTF moieties (1, 3 and 4) have demonstrated higher binding abilities toward C70 than C60. Depending on the linker used

  已经合成了一系列新的exTTF宿主，用于富勒烯C 60和C 70的超分子结合研究。计算了不同主体之间氯苯，甲苯，甲苯-CH 2 Cl 2和CS 2中C 60的结合常数，并建立了直接的结构亲和性关系。正如预测的那样，受体具有两个exTTF部分（1，3和4）已经表现出较高的结合朝向Ç能力70比C 60。取决于用于将exTTF单元连接至宿主核心的连接子，已获得了不同的结合模式（1：1和2：1）。
• Syntheses of heterocyclic compounds, part XXI. Oxazoles from pyrolysis of aryl and heterocyclic azides in a mixture of acetic and polyphosphoric acid
  作者：E. B. Mullock、H. Suschitzky

  DOI：10.1039/j39680001937

  日期：——

  Pyrolysis of 2-azido-naphthalene, -anthraquinone, and various azido-heterocycles in a mixture of polyphosphoric and acetic acid results in fusion of an oxazolo-moiety on to the parent system. The scope of this convenient oxazole synthesis in its widest sense is discussed.

  在多磷酸和乙酸的混合物中2-叠氮基萘，蒽醌和各种叠氮基杂环的热解导致恶唑基部分融合到母体系统上。从最广泛的意义上讨论了这种方便的恶唑合成的范围。
• Process for production of vinyl chloride polymer
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0172427A2

  公开（公告）日：1986-02-26

  This process is a process for production of a vinyl chloride polymer by suspension polymerization or emulsion polymerization of vinyl chloride monomer or a mixture of vinyl chloride monomer with a vinyl monomer copolymerizable with said vinyl chloride monomer in an aqueous medium, characterized in that the polymerization is carried out in a polymerizer, the inner wall surface and portions of the auxiliary equipment thereof which may come into contact with the monomer during polymerization being previously coated with a scaling preventive comprising at least one selected from dyes, pigments and aromatic or heterocyclic compounds having at least 5 conjugated π bonds, while controlling the chloride ion concentration in the reaction mixture to not higher than 100 ppm. According to said process, scaling onto the inner wall surface of a polymerizer, etc. during polymerization can be prevented effectively and surely.

  该工艺是通过氯乙烯单体或氯乙烯单体与可与所述氯乙烯单体共聚的乙烯基单体混合物在水介质中进行悬浮聚合或乳液聚合来生产氯乙烯聚合物的工艺，其特征在于聚合是在聚合器中进行的、内壁表面及其辅助设备中可能在聚合过程中与单体接触的部分事先涂上一层防垢剂，该防垢剂至少包括一种选自染料、颜料和至少有 5 个共轭 π 键的芳香族或杂环化合物的防垢剂，同时控制反应混合物中的氯离子浓度不高于 100 ppm。根据上述工艺，可有效、可靠地防止聚合过程中聚合器等内壁表面结垢。
• Novel aromatic azides for type I phototherapy
  申请人：Mallinckrodt Inc.

  公开号：US20020169107A1

  公开（公告）日：2002-11-14

  The present invention discloses novel aromatic azide derivatives and their bioconjugates for phototherapy of tumors and other lesions. The organic azides of the present invention are designed to absorb low-energy ultraviolet, visible, or near-infrared (NIR) region of the electromagnetic spectrum. The phototherapeutic effect is caused by direct interaction of nitrene, the reactive intermediate produced upon photoexcitation of the aromatic azide, with the tissue of interest. The compounds of the present invention are administered to a patient, allowed to accumulate at the site of the tumor or other lesion, and are exposed to light in order to perform a phototherapeutic procedure.

  本发明公开了用于肿瘤和其他病变光疗的新型芳香族叠氮化物衍生物及其生物共轭物。本发明的有机叠氮化物可吸收电磁波谱中的低能量紫外线、可见光或近红外（NIR）区域。光疗效果是由芳香族叠氮化物光激发时产生的反应性中间体--腈与相关组织直接相互作用而产生的。给病人服用本发明的化合物，让其在肿瘤或其他病变部位积聚，并将其暴露在光下，以进行光治疗程序。