5,5-diethyl-2-methyl-1H-pyrimidine-4,6-dione | 90565-88-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5,5-diethyl-2-methyl-1H-pyrimidine-4,6-dione
• 英文别名: 5,5-Diaethyl-2-methyl-1H-pyrimidin-4,6-dion；5,5-Diethyl-2-methylpyrimidine-4,6-dione；5,5-diethyl-2-methyl-1H-pyrimidine-4,6-dione
• CAS: 90565-88-1
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.222
• InChiKey: MLYYUYGWIATDQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  58.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,5-diethyl-2-methyl-1H-pyrimidine-4,6-dione 、 alkaline earth salt of/the/ methylsulfuric acid 生成 戊烷-3,3-二甲酰胺
  参考文献：
  名称：

  Childlessness and the Psychological Well-Being of Older Persons

  摘要：

  Objectives. Rapid growth in the size of the childless elderly population has prompted concerns about the negative effects of childlessness on psychological well-being. This study adds to this line of inquiry by examining the effects of childlessness on two important dimensions of elderly persons' psychological well-being: loneliness and depression.Methods. Using the 1993 Asset and Health Dynamics Among the Oldest Old data set, the authors estimated logistic and ordinary least squares regression models of psychological well-being for a nationally representative sample of people aged 70 and older (N = 6,517).Results. Childlessness per se did not significantly increase the prevalence of loneliness and depression at advanced ages, net of other factors. There also was no statistical evidence for the hypothesis that childlessness increases loneliness and depression for divorced, widowed, and never married elderly persons. Sex, however, altered how childlessness and marital status influenced psychological well-being. Divorced, widowed, and never married men who were childless had significantly higher rates of loneliness compared with women in comparable circumstances; divorced and widowed men who were childless also had significantly higher rates of depression than divorced and widowed women.Discussion. The Findings suggest that it is important to understand the consequences of childlessness in the context of marital status and sex.

  DOI：

  10.1093/geronb/56.5.s311
• 作为产物：
  描述：

  乙酰胺 、 二氯化二乙基丙二酰 生成 5,5-diethyl-2-methyl-1H-pyrimidine-4,6-dione
  参考文献：
  名称：

  Childlessness and the Psychological Well-Being of Older Persons

  摘要：

  Objectives. Rapid growth in the size of the childless elderly population has prompted concerns about the negative effects of childlessness on psychological well-being. This study adds to this line of inquiry by examining the effects of childlessness on two important dimensions of elderly persons' psychological well-being: loneliness and depression.Methods. Using the 1993 Asset and Health Dynamics Among the Oldest Old data set, the authors estimated logistic and ordinary least squares regression models of psychological well-being for a nationally representative sample of people aged 70 and older (N = 6,517).Results. Childlessness per se did not significantly increase the prevalence of loneliness and depression at advanced ages, net of other factors. There also was no statistical evidence for the hypothesis that childlessness increases loneliness and depression for divorced, widowed, and never married elderly persons. Sex, however, altered how childlessness and marital status influenced psychological well-being. Divorced, widowed, and never married men who were childless had significantly higher rates of loneliness compared with women in comparable circumstances; divorced and widowed men who were childless also had significantly higher rates of depression than divorced and widowed women.Discussion. The Findings suggest that it is important to understand the consequences of childlessness in the context of marital status and sex.

  DOI：

  10.1093/geronb/56.5.s311

文献信息

• Childlessness and the Psychological Well-Being of Older Persons
  作者：Z. Zhang、M. D. Hayward

  DOI：10.1093/geronb/56.5.s311

  日期：2001.9.1

  Objectives. Rapid growth in the size of the childless elderly population has prompted concerns about the negative effects of childlessness on psychological well-being. This study adds to this line of inquiry by examining the effects of childlessness on two important dimensions of elderly persons' psychological well-being: loneliness and depression.Methods. Using the 1993 Asset and Health Dynamics Among the Oldest Old data set, the authors estimated logistic and ordinary least squares regression models of psychological well-being for a nationally representative sample of people aged 70 and older (N = 6,517).Results. Childlessness per se did not significantly increase the prevalence of loneliness and depression at advanced ages, net of other factors. There also was no statistical evidence for the hypothesis that childlessness increases loneliness and depression for divorced, widowed, and never married elderly persons. Sex, however, altered how childlessness and marital status influenced psychological well-being. Divorced, widowed, and never married men who were childless had significantly higher rates of loneliness compared with women in comparable circumstances; divorced and widowed men who were childless also had significantly higher rates of depression than divorced and widowed women.Discussion. The Findings suggest that it is important to understand the consequences of childlessness in the context of marital status and sex.