ethyl 2-bromo-5-methylamino-thiazole-4-carboxylate | 1333571-03-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 2-bromo-5-methylamino-thiazole-4-carboxylate
• 英文别名: Ethyl 2-bromo-5-(methylamino)-1,3-thiazole-4-carboxylate
• CAS: 1333571-03-1
• 化学式: C₇H₉BrN₂O₂S
• mdl: MFCD19982349
• 分子量: 265.131
• InChiKey: VZVRHFLKKZUPQS-UHFFFAOYSA-N

物化性质

• 沸点：
  336.4±22.0 °C(Predicted)
• 密度：
  1.634±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  79.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 2-bromo-5-methylamino-thiazole-4-carboxylate 在 盐酸 、 草酰氯 、 N,N-二异丙基乙胺 、 N,N-二甲基甲酰胺 作用下， 以 1,4-二氧六环 、 乙醚 、 乙醇 、 二氯甲烷 为溶剂， 反应 71.17h， 生成 5-methylamino-2-[2-[[(E)-4 ,4 ,4-trifluorobut-2-enoyl]amino]ethylamino]-thiazole-4-carboxylate
  参考文献：
  名称：

  [EN] HETEROARYL COMPOUNDS WITH A-CYCLIC BRIDGING UNIT
  [FR] COMPOSÉS HÉTÉROARYLES À UNITÉ DE PONTAGE CYCLIQUE

  摘要：

  这项发明涉及某些杂环芳基化合物，可用作药物，更具体地用作治疗动物的药物。该药物可用于治疗寄生虫感染，如蠕虫感染，以及由这些感染引起的寄生虫病的治疗。该发明还涉及利用这些化合物制备药物和治疗方法，包括将这些化合物给需要治疗的动物。该发明还涉及包含这些化合物的药物组合物和试剂盒。

  公开号：

  WO2013144179A1

文献信息

• [EN] HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR USE IN THE TREATMENT HELMINTH INFECTION<br/>[FR] COMPOSÉS HÉTÉROARYLES À UNITÉ DE PONTAGE CYCLIQUE UTILISÉS DANS LE TRAITEMENT D'INFECTIONS HELMINTHIQUES
  申请人：INTERVET INT BV

  公开号：WO2013144180A1

  公开（公告）日：2013-10-03

  This invention relates to certain heteroaryl compounds for use as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of helminth infections and the treatment of parasitosis caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及某些杂环烯基化合物，用作药物，更具体地用作治疗动物的药物。该药物可用于治疗蠕虫感染和由蠕虫感染引起的寄生虫病的治疗。本发明还涉及利用这些化合物制备药物和治疗方法，包括将这些化合物给予需要治疗的动物。本发明还涉及包含这些化合物的药物组合物和配套工具。
• HETEROARYL COMPOUNDS WITH A-CYCLIC BRIDGING UNIT
  申请人：Intervet Inc.

  公开号：US20150057279A1

  公开（公告）日：2015-02-26

  This invention relates to certain heteroaryl compounds which may be used as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of parasitic infections such as helminth infections and the treatment of parasitosis caused by such infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及某些杂环芳基化合物，可用作药物，更具体地用作治疗动物的药物。该药物可用于治疗寄生虫感染，如蠕虫感染和由此类感染引起的寄生虫病的治疗。本发明还涉及使用该化合物制备药物和治疗，包括将该化合物给需要治疗的动物。本发明还涉及包含该化合物的制药组合物和试剂盒。
• HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT
  申请人：Intervet Inc.

  公开号：US20150080365A1

  公开（公告）日：2015-03-19

  This invention relates to certain heteroaryl compounds for use as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of helminth infections and the treatment of parasitosis caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及某些杂环芳基化合物，用作药物，更具体地用作治疗动物的药物。该药物可用于治疗蠕虫感染和由蠕虫感染引起的寄生虫病的治疗。本发明还涉及使用这些化合物制造药物和治疗，包括将这些化合物用于需要治疗的动物的给药。本发明还涉及包含这些化合物的制药组合物和套装。
• Heteroaryl compounds with cyclic bridging unit
  申请人：Intervet Inc.

  公开号：US09260441B2

  公开（公告）日：2016-02-16

  This invention relates to certain heteroaryl compounds for use as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of helminth infections and the treatment of parasitosis caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及某些杂环芳基化合物，用作药物，更具体地用作治疗动物的药物。该药物可用于治疗蠕虫感染和由蠕虫感染引起的寄生虫病的治疗。本发明还涉及利用这些化合物制备药物和治疗方案，包括将这些化合物给需要治疗的动物进行治疗。本发明还涉及包含这些化合物的制药组合物和试剂盒。
• Heteroaryl compounds with A-cyclic bridging unit
  申请人：Intervet Inc.

  公开号：US09321724B2

  公开（公告）日：2016-04-26

  This invention relates to certain heteroaryl compounds which may be used as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of parasitic infections such as helminth infections and the treatment of parasitosis caused by such infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及某些杂环芳基化合物，可用作药物，更具体地用作治疗动物的药物。该药物可用于治疗寄生虫感染，如蠕虫感染和由此类感染引起的寄生虫病的治疗。本发明还涉及使用这些化合物制作药物和治疗方法，包括将这些化合物用于需要治疗的动物的治疗中。本发明还涉及包含这些化合物的制药组合物和试剂盒。