1-hydrazinyl-2-(2-methyl-5-nitro-1H-benzimidazol-1-yl)acetonitrile | 913706-13-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-hydrazinyl-2-(2-methyl-5-nitro-1H-benzimidazol-1-yl)acetonitrile
• 英文别名: (2-Methyl-5-nitro-1H-benzimidazol-1-yl)ethanehydrazonamide；N'-amino-2-(2-methyl-5-nitrobenzimidazol-1-yl)ethanimidamide
• CAS: 913706-13-5
• 化学式: C₁₀H₁₂N₆O₂
• 分子量: 248.244
• InChiKey: CQOPYSWMNSRMPU-UHFFFAOYSA-N

物化性质

• 熔点：
  195-197 °C(Solv: ethanol (64-17-5))
• 沸点：
  485.9±51.0 °C(Predicted)
• 密度：
  1.60±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  128
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-hydrazinyl-2-(2-methyl-5-nitro-1H-benzimidazol-1-yl)acetonitrile 在 氯化亚砜 、 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以76%的产率得到2-methyl-5-nitro-1-(1-oxo-2,3-dihydro-1,2,3,5-thiatriazol-4-ylmethyl)-1H-benzimidazole
  参考文献：
  名称：

  Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles

  摘要：

  Different substituents were introduced in position 1 of 2-methyl-5(6)-nitro-1H-benzimidazole (2) in order to obtain different side chains having different heterocyclic compounds, for example, thiadiazoles (5-7), tetrazoles (8, 9a, b), triazoles (11-13), thiazoles (14a-e), triazines (10, 16, 17), and imidazoles (18a-c). The antitumor effect of compounds 1, 2, 2a, 4, 5, 7, 8, 9a, 10, 13, 14a, 15, 16, and 18c was studied against breast cancer (MCF7) and compounds 2 [IC50 = 4.52 mu g] and 7 [IC50 = 8.29 mu g] were found to be active. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.06.033
• 作为产物：
  描述：

  2-甲基-5-硝基苯并咪唑 在 sodium hydride 、 一水合肼 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 13.0h， 生成 1-hydrazinyl-2-(2-methyl-5-nitro-1H-benzimidazol-1-yl)acetonitrile
  参考文献：
  名称：

  Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles

  摘要：

  Different substituents were introduced in position 1 of 2-methyl-5(6)-nitro-1H-benzimidazole (2) in order to obtain different side chains having different heterocyclic compounds, for example, thiadiazoles (5-7), tetrazoles (8, 9a, b), triazoles (11-13), thiazoles (14a-e), triazines (10, 16, 17), and imidazoles (18a-c). The antitumor effect of compounds 1, 2, 2a, 4, 5, 7, 8, 9a, 10, 13, 14a, 15, 16, and 18c was studied against breast cancer (MCF7) and compounds 2 [IC50 = 4.52 mu g] and 7 [IC50 = 8.29 mu g] were found to be active. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.06.033

文献信息

• Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles
  作者：Mostafa M. Ramla、Mohamed A. Omar、Abdel-Momen M. El-Khamry、Hoda I. El-Diwani

  DOI：10.1016/j.bmc.2006.06.033

  日期：2006.11

  Different substituents were introduced in position 1 of 2-methyl-5(6)-nitro-1H-benzimidazole (2) in order to obtain different side chains having different heterocyclic compounds, for example, thiadiazoles (5-7), tetrazoles (8, 9a, b), triazoles (11-13), thiazoles (14a-e), triazines (10, 16, 17), and imidazoles (18a-c). The antitumor effect of compounds 1, 2, 2a, 4, 5, 7, 8, 9a, 10, 13, 14a, 15, 16, and 18c was studied against breast cancer (MCF7) and compounds 2 [IC50 = 4.52 mu g] and 7 [IC50 = 8.29 mu g] were found to be active. (c) 2006 Elsevier Ltd. All rights reserved.