1,3-diphenylimidazol-2-one | 21377-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,3-diphenylimidazol-2-one
• 英文别名: 1,3-diphenyl-1,3-dihydro-imidazol-2-one；1,3-Diphenyl-δ⁴-imidazolinon-(2)；1,3-Diphenyl-imidazolon-(2)
• CAS: 21377-16-2
• 化学式: C₁₅H₁₂N₂O
• 分子量: 236.273
• InChiKey: JUQHZCASOZCEST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3-二甲基马来酸酐 、 1,3-diphenylimidazol-2-one 以 苯 为溶剂， 生成 6,7-dimethyl-3-oxo-2,4-diphenyl-(1rH,5cH)-2,4-diaza-bicyclo[3.2.0]heptane-6c,7c-dicarboxylic acid anhydride
  参考文献：
  名称：

  Steffan,G., Chemische Berichte, 1968, vol. 101, # 11, p. 3688 - 3695

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-duphenyl-2-trifloxyimidazolium triflate 、 1,3-diphenylimidazole-2-thione 以77%的产率得到
  参考文献：
  名称：

  MAAS G.; STANG P. J., J. ORG. CHEM., 1981, 46, NO 8, 1606-1610

  摘要：

  DOI：

文献信息

• Dication ether salts, R+-O-R+.2CF3SO3-, from the reaction of trifluoromethanesulfonic anhydride with activated ketones
  作者：Peter J. Stang、Gerhard Maas、David L. Smith、James A. McCloskey

  DOI：10.1021/ja00406a028

  日期：1981.8
• Dication disulfides by reaction of thioureas and related compounds with trifluoromethanesulfonic anhydride. The role of triflic anhydride as an oxidizing agent
  作者：Gerhard Maas、Peter J. Stang

  DOI：10.1021/jo00321a015

  日期：1981.4
• VERFAHREN ZUR HERSTELLUNG VON 3-AMINOBIPHENYLEN
  申请人：Technische Universität München

  公开号：EP2342174B1

  公开（公告）日：2013-03-27
• ANIMAL MODELS, SCREENING METHODS, AND TREATMENT METHODS FOR INTRAOCULAR DISEASES OR DISORDERS
  申请人：ZHUHAI QIWEI BIO-TECHNOLOGY LTD.

  公开号：US20220015338A1

  公开（公告）日：2022-01-20

  Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium . Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
• [EN] ANIMAL MODELS, SCREENING METHODS, AND TREATMENT METHODS FOR INTRAOCULAR DISEASES OR DISORDERS<br/>[FR] MODÈLES D'ANIMAUX, PROCÉDÉS DE CRIBLAGE, ET PROCÉDÉS DE TRAITEMENT POUR MALADIES OU TROUBLES INTRAOCULAIRES
  申请人：ZHUHAI QIWEI BIO TECH LTD

  公开号：WO2020098630A1

  公开（公告）日：2020-05-22

  Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.