((HOOCCH2)2NHCOCH2)NCH2CH2N(CH2COOH)CH2CH2N(CH2COOH)(CH2CONH((C9H4O-2-O-4-CH3)-7))

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ((HOOCCH2)2NHCOCH2)NCH2CH2N(CH2COOH)CH2CH2N(CH2COOH)(CH2CONH((C9H4O-2-O-4-CH3)-7))
• 英文别名: DTPA-mono(7-amino-4-methylcoumarin)amide；2-[2-[Bis(carboxymethyl)amino]ethyl-[2-[carboxymethyl-[2-[(4-methyl-2-oxochromen-7-yl)amino]-2-oxoethyl]amino]ethyl]amino]acetic acid；2-[2-[bis(carboxymethyl)amino]ethyl-[2-[carboxymethyl-[2-[(4-methyl-2-oxochromen-7-yl)amino]-2-oxoethyl]amino]ethyl]amino]acetic acid
• 化学式: C₂₄H₃₀N₄O₁₁
• 分子量: 550.522
• InChiKey: KMOVLOBCCNONDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.9
• 重原子数：
  39
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  214
• 氢给体数：
  5
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  ((HOOCCH2)2NHCOCH2)NCH2CH2N(CH2COOH)CH2CH2N(CH2COOH)(CH2CONH((C9H4O-2-O-4-CH3)-7)) 在 盐酸 、 indium(III) chloride 、 sodium acetate 作用下， 以 水 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  [EN] LUMINESCENT METAL COMPLEXES FOR MONITORING RENAL FUNCTION
  [FR] COMPLEXES MÉTALLIQUES LUMINESCENTS POUR LA SURVEILLANCE DES FONCTIONS RÉNALES

  摘要：

  本发明的某些实施例可被称为公式I的金属配合物，其中X1、X2、X3、R1、R2、R3、R4和R5中至少一个可被表征为天线，能够提供（例如吸收和/或发射）适当的电磁信号。本发明的某些实施例涉及与公式I的金属配合物相对应的配体。本发明的某些实施例涉及使用至少一个公式I的金属配合物来确定肾功能的方法。

  公开号：

  WO2006026038A1
• 作为产物：
  描述：

  二亚乙基三胺五乙酸二酐 、 7-氨基-4-甲基香豆素 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 生成 ((HOOCCH2)2NHCOCH2)NCH2CH2N(CH2COOH)CH2CH2N(CH2COOH)(CH2CONH((C9H4O-2-O-4-CH3)-7))
  参考文献：
  名称：

  Triple-Emitting Dumbbell Fluorescent Nanoprobe for Multicolor Detection and Imaging Applications

  摘要：

  The combination of different fluorescent species into one nanostructure to develop fluorescent nanoparticles with multiple emission signatures by a single wavelength excitation has become a very popular research area in the field of multiplex bioanalysis, diagnostics, and multicolor imaging. However, these novel hybrids must be elaborately designed to ensure that the unique properties of each component are conveyed, i.e., fluorescent species and nanoparticles, and are maximized without serious interactions with each other. Herein, a first triple-fluorescence dumbbell nanoprobe with large Stokes shift based on incorporating fluorescein isothiocyanate (FITC) and lanthanide complexes onto Au-Fe3O4 NPs was synthesized. This hybrid displays well-resolved triple fluorescence emission, with FITC at 515 nm, Tb(III) complex at 545 nm, and Eu(III) complex at 616 run under a single-excitation wavelength and is used for highly selective and sensitive colorimetric detection of Cu2+ with a detection limit of 30 nM. Under different Cu2+ concentrations, this hybrid exhibited distinguishable multiple colors under UV light, and the color could change in the presence of different concentrations of Cu2+. This sensor for ratio/multianalyte microscopic imaging of Cu2+ in HeLa cells and BHK cells was also demonstrated. Target molecules, such as folic acid, can be covalently attached to the fluorescent nanoparticle surface to serve as an effective probe for simultaneous multicolor imaging folate receptor-overexpressing HeLa cell lines in vitro.

  DOI：

  10.1021/acs.inorgchem.5b00610

文献信息

• Sensitization of Europium(III) Luminescence by DTPA Derivatives
  作者：Hiroaki Ozaki、Emiko Suda、Toshihisa Nagano、Hiroaki Sawai

  DOI：10.1246/cl.2000.312

  日期：2000.4

  Novel ligands, diethylenetriaminepentaacetic acid bearing several aromatic amines, were synthesized and their chelates with a europium ion were prepared. The lanthanide luminescence of the chelates of 1-aminonaphthalene and 7-amino-4-methylcoumarin was largely enhanced by the energy transfer from the ligand to the europium ion.

  合成了新型配体，含有多种芳香胺的二乙烯三胺五乙酸，并制备了其与铕离子的络合物。1-氨基萘和7-氨基-4-甲基香豆素的络合物的镧系离子发光在配体与铕离子之间的能量转移的作用下得到了显著增强。