nitrilotriacetic acid N-oxide | 3055-17-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: nitrilotriacetic acid N-oxide
• 英文别名: Nitrilotriessigsaeure N-oxid；Nitrilotriessigsaeure-N-oxid；Tris-carboxymethyl-aminoxid；Carboxy-N,N-bis(carboxymethyl)methanamine N-oxide；N,N-bis(carboxymethyl)-2-hydroxy-2-oxoethanamine oxide
• CAS: 3055-17-2
• 化学式: C₆H₉NO₇
• 分子量: 207.14
• InChiKey: IGJPJVRRDBSNTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  130
• 氢给体数：
  3
• 氢受体数：
  7

安全信息

• 海关编码：
  2922509090

反应信息

• 作为产物：
  描述：

  次氮基三乙酸 在 sodium hydroxide 、 双氧水 作用下， 生成 nitrilotriacetic acid N-oxide
  参考文献：
  名称：

  Coeur,A.; Alary,J., Bulletin de la Societe Chimique de France, 1964, p. 2412 - 2414

  摘要：

  DOI：

文献信息

• A drug and method for increasing the microcirculatory flow-rate and volume in the capillaries to the skin
  申请人：Bertini Curri, Sergio

  公开号：EP0369105A1

  公开（公告）日：1990-05-23

  A drug is described which includes a physico-chemical complex between molecules of a phospholipid and an aminoketone derivative of fluoroglucinol which is useful, particularly when administered topically in the form of a liposomal aqueous microdispersion, for increasing the microcirculatory flow-rate and volume in the capillaries to the skin, both in normal conditions and in peripheral vasculopathy (primary or secondary Raynaud's disease), acrocyanosis and blocked arteries caused by arteriosclerosis, diabetes or endoangioitis obliterans.

  描述了一种药物，它包括磷脂分子与氟葡糖醇的氨基酮衍生物之间的物理化学复合物，特别是以脂质体水溶液微分散体的形式局部给药时非常有用、用于增加皮肤毛细血管的微循环流速和流量，无论是在正常情况下，还是在外周血管病变（原发性或继发性雷诺氏病）、痤疮和由动脉硬化、糖尿病或闭塞性血管内炎引起的动脉阻塞的情况下。
• Method for increasing the production of physiologically active substances by cultured cells
  申请人：Welfide Corporation

  公开号：EP1096017A2

  公开（公告）日：2001-05-02

  The production of a physiologically active substance by a normal, transfected or transformed cultured cell can be increased by culturing the cell in a culture medium containing cobalt and molybdenum. The culture medium is one ordinarily selected for growing those types of cells which produce a desired, physiologically active substance, e.g., a recombinant growth factor of a monoclonal antibody. When cobalt and molybdenum are included in any of these growth media, a substantial improvement in the production of a physiologically active substance by the cells can be observed. Compositions and methods utilizing cobalt and molybdenum as additives for culture media are described.

  通过在含钴和钼的培养基中培养正常的、转染的或转化的培养细胞，可以提高其生理活性物质的产量。这种培养基通常用于培养能产生所需生理活性物质（如单克隆抗体的重组生长因子）的细胞。将钴和钼加入任何一种生长培养基中，都可以观察到细胞生产生理活性物质的情况有了很大改善。本文介绍了利用钴和钼作为培养基添加剂的组合物和方法。
• Munoz, Florinella; Von Sonntag, Clemens, Journal of the Chemical Society. Perkin Transactions 2 (2001), 2000, # 10, p. 2029 - 2033
  作者：Munoz, Florinella、Von Sonntag, Clemens

  DOI：——

  日期：——
• US5280020A
  申请人：——

  公开号：US5280020A

  公开（公告）日：1994-01-18
• Coeur,A.; Alary,J., Bulletin de la Societe Chimique de France, 1964, p. 2412 - 2414
  作者：Coeur,A.、Alary,J.

  DOI：——

  日期：——