2,6-bis(4-formylphenoxymethyl)pyridine | 144106-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,6-bis(4-formylphenoxymethyl)pyridine
• 英文别名: 2,6-Bis-(4-formyl-phenoxymethyl)-pyridine；4-[[6-[(4-formylphenoxy)methyl]pyridin-2-yl]methoxy]benzaldehyde
• CAS: 144106-20-7
• 化学式: C₂₁H₁₇NO₄
• 分子量: 347.37
• InChiKey: KAOBPHAYFLMYEB-UHFFFAOYSA-N

物化性质

• 熔点：
  176-177 °C
• 沸点：
  559.7±45.0 °C(Predicted)
• 密度：
  1.261±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  65.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,6-bis(4-formylphenoxymethyl)pyridine 在 sodium tetrahydroborate 、 三溴化磷 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 18.0h， 生成 2,6-Di(p-bromomethylphenoxymethyl)pyridine
  参考文献：
  名称：

  基于间三联苯基和吡啶基嵌段的手性环烷烃的合成

  摘要：

  的耦合米与BINOL三联苯二溴化物，得到相应的光学活性环芳。还可以通过将对硝基苯酚或4,4″-双（溴甲基）-1，3-二苄基苯与对苯二酚偶联而获得手性环烷。

  DOI：

  10.1016/s0040-4020(01)00966-8
• 作为产物：
  描述：

  2,6-二氯甲基吡啶 、 对羟基苯甲醛 在 氢氧化钾 作用下， 生成 2,6-bis(4-formylphenoxymethyl)pyridine
  参考文献：
  名称：

  Kamalov, G. L.; Zakolodyazhnaya, O. V.; Manolova, A. V., Journal of general chemistry of the USSR, 1992, vol. 62, # 3.2, p. 561 - 566

  摘要：

  DOI：

文献信息

• Systematic synthetic and biophysical development of mixed sequence DNA binding agents
  作者：Ananya Paul、Arvind Kumar、Rupesh Nanjunda、Abdelbasset A. Farahat、David W. Boykin、W. David Wilson

  DOI：10.1039/c6ob02390h

  日期：——

  recognize mixed DNA sequences and for progress in targeting specific genes, it is essential to have additional classes of compounds. Compounds that can be rationally designed from established modules and which can bind strongly to mixed base pair DNA sequences are especially attractive. Based on extensive experience in design of minor-groove agents for AT recognition, a small library of compounds with

  现已公认，尽管仅约5％的人类基因组编码蛋白质，但大多数DNA仍具有某些功能，例如合成特定的功能性RNA和/或控制基因表达。这些功能性序列为使用可渗透细胞的小分子（可结合DNA的混合碱基对序列调节基因组功能）打开了巨大的可能性，在生物技术和治疗学领域均如此。不幸的是，已经设计出很少类型的模块来识别混合的DNA序列，并且为了靶向特定基因的进步，必须拥有更多种类的化合物。可以从已建立的模块中合理设计并且可以与混合碱基对DNA序列强烈结合的化合物特别有吸引力。基于在用于AT识别的小沟剂设计方面的丰富经验，制备了一个小化合物库，该化合物具有两个AT特异性结合模块，这些模块通过可识别G·C碱基对的接头连接。使用强大的生物物理方法对化合物-DNA的相互作用进行了评估，结果表明，一些吡啶基连接的化合物与靶序列结合，具有亚纳摩尔级K D，在没有G·C碱基对的情况下，解离动力学非常慢，选择性是相关序列的200
• Microwave Assisted Multi-Component Synthesis of Novel Bis(1,4-dihydropyridines) Based Arenes or Heteroarenes
  作者：Ahmed H. M. Elwahy、Ismail A. Abdelhamid、Sherif M. H. Sanad、Refaie M. Kassab

  DOI：10.3987/com-16-13441

  日期：——

  A synthesis of novel bis-1,4-DHPs was reported. Two possible synthetic approaches for these compounds were investigated. In the first approach the monopodal 1,4-DHPs were used as building blocks for the construction of the target molecules via a simple alkylation. In the second strategy the appropriate bis-aldehydes have been synthesized in a first step followed by reaction with four equivalents of 3-aminobut-2-enenitrile using different catalysts under microwave irradiation as well as under conventional heating to give the corresponding bis-1,4-DHPs in good to excellent yield. The oxidative aromatization of some derivatives of the latter compounds into the corresponding bis-2,6-dimethylpyridine-3,5-dicarbonitrile derivatives was achieved using ceric ammonium nitrate (CAN).
• Synthesis of intra-annularly functionalized cationic pyridinophanes
  作者：Perumal Rajakumar、Manickam Dhanasekaran

  DOI：10.1016/s0040-4020(01)01226-1

  日期：2002.2

  The precyclophane 1 derived from 2,6-bis(bromomethyl)pyridine and 2.1 equiv. of benzimidazole afforded pyridinobenz-imidazolophanes 6-8 on further reaction with I equiv. of 2,6-bis(bromomethyl)pyridine, 3,5 -bis(bromomethyl) ani sole and 1,3-bis(bromomethyl)-4-nitrophenol, respectively. A similar synthetic strategy was used for the synthesis of pyridinobenzotriazolophanes 9-11. Potential receptors 16 and 17 were also synthesized. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Kamalov, G. L.; Zakolodyashnaya, O. V.; Manolova, A. V., Journal of general chemistry of the USSR, 1992, vol. 62, # 6.2, p. 1147 - 1153
  作者：Kamalov, G. L.、Zakolodyashnaya, O. V.、Manolova, A. V.、Lozitskaya, R. N.、Gavsevich, Yu. V.

  DOI：——

  日期：——
• Kamalov, G. L.; Zakolodyazhnaya, O. V.; Manolova, A. V., Journal of general chemistry of the USSR, 1992, vol. 62, # 3.2, p. 567 - 571
  作者：Kamalov, G. L.、Zakolodyazhnaya, O. V.、Manolova, A. V.、Gavsevich, Yu. V.、Lozitskaya, R. N.、Zakolodyazhnaya, Yu. O.

  DOI：——

  日期：——