L-valine tert-butylamide | 3057-81-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-valine tert-butylamide
• 英文别名: 2-amino-N-tert-butyl-3-methylbutanamide
• CAS: 3057-81-6
• 化学式: C₉H₂₀N₂O
• mdl: MFCD07781141
• 分子量: 172.271
• InChiKey: SIZVNUMWTAXYAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 L-valine tert-butylamide 在 三乙胺 作用下， 生成 2-acetamido-N-tert-butyl-3-methylbutanamide
  参考文献：
  名称：

  Optical resolution of D- and L-amino acid derivatives by silica gel liquid chromatography with chiral additive N-acetyl-L-valine tert-butylamide

  摘要：

  DOI：

  10.1021/ac00261a036
• 作为产物：
  描述：

  异氰酸叔丁酯 、 异丁醛 在 氯化铵 作用下， 以 水 为溶剂， 反应 18.0h， 生成 N'-tert-butyl-2-hydroxy-3-methylbutanimidamide 、 、 α-Hydroxy-(N-tert.-butyl)-isovaleramid 、 L-valine tert-butylamide
  参考文献：
  名称：

  通过潜在的益生元多组分反应同时进行核苷酸活化和氨基酸酰胺的合成。

  摘要：

  DOI：

  10.1002/anie.200702870

文献信息

• A process for the resolution of a racemate
  申请人：Laporte Industries Limited

  公开号：EP0182170A2

  公开（公告）日：1986-05-28

  A racemate may be resolved into its enantiomers by stereoselective adsorption on a crystalline molecular sieve having an assymetric crystal structure for example zeolite ZSM11. The resolution may be assisted by the presence of an enantiomer of a compound separable from that of the racemate either preadsorbed on the molecular sieve or included in a polar solvent solution of the racemate to be treated. Resolution of an alkyl aryl sulphoxide racemate is exemplified.

  外消旋物可以通过立体选择性吸附在具有非对称性晶体结构的结晶分子筛（例如沸石 ZSM11）上而分解成其对映体。 在分子筛上预先吸附或包含在待处理的外消旋物的极性溶剂溶液中的可与外消旋物分离的化合物对映体的存在可以帮助分解。 烷基芳基亚砜外消旋物的分解就是一个例子。
• Hybrid Amphotericin B derivatives with reduced toxicity
  申请人：The Board of Trustees of the University of Illinois

  公开号：US11198705B2

  公开（公告）日：2021-12-14

  Disclosed are derivatives of amphotericin B (AmB) characterized by improved clinical efficacy with reduced toxicity compared to AmB. Also disclosed are pharmaceutical compositions comprising the AmB derivatives, therapeutic methods of using the AmB derivatives and methods of making the AmB derivatives.

  公开了两性霉素 B（AmB）的衍生物，其特点是与 AmB 相比，临床疗效提高，毒性降低。还公开了包含 AmB 衍生物的药物组合物、使用 AmB 衍生物的治疗方法和制造 AmB 衍生物的方法。
• SHIP 1 MODULATOR PRODRUGS
  申请人：Andersen Raymond

  公开号：US20100323990A1

  公开（公告）日：2010-12-23

  The present invention provides the use of prodrugs of pelorol and homopelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions.
• SHIP 1 MODULATOR COMPOUNDS
  申请人：Andersen Raymond

  公开号：US20110263539A1

  公开（公告）日：2011-10-27

  The present invention provides the use of pelorol analogs of Formula, (I) and pharmaceutical compositions thereof as modulators of SHIP 1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions.
• SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE
  申请人：AbbVie Inc.

  公开号：US20180071262A1

  公开（公告）日：2018-03-15

  Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R 1 , R 2a , R 2b , R 3a , R 3b , R 4a , R 4b , Q 1 ----Q 2 , R 6 , R 7 , A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.