Cbo-glycyl-aminomalonsaeurediethylester | 14769-29-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cbo-glycyl-aminomalonsaeurediethylester
• 英文别名: ethyl N-[(benzyloxy)carbonyl]glycyl-O-ethyl-3-oxoserinate；diethyl 2-[[2-(benzyloxycarbonylamino)acetyl]amino]propanedioate；[(N-benzyloxycarbonyl-glycyl)-amino]-malonic acid diethyl ester；[(N-Benzyloxycarbonyl-glycyl)-amino]-malonsaeure-diaethylester；diethyl 2-[[N-(benzyloxycarbonyl)glycyl]amino]malonate；diethyl 2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]propanedioate
• CAS: 14769-29-0
• 化学式: C₁₇H₂₂N₂O₇
• 分子量: 366.371
• InChiKey: BQGHTCXNIKVHBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  26
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Cbo-glycyl-aminomalonsaeurediethylester 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 42.0h， 生成 3,6-diethoxy-2,5-dihydro-2-pyrazinecarboxylate
  参考文献：
  名称：

  6-Alkyl-2,5-bisethoxy-3-ethoxycarbonyl-3,6-dihydropyrazine aus Piperazin-2,5-dionen 6-Alkyl-2,5-bisethoxy-3-ethoxycarbonyl-3,6-dihydropyrazines from Piperazine-2,5-diones

  摘要：

  DOI：

  10.1002/ardp.19833160716
• 作为产物：
  描述：

  N-苄氧羰基甘氨酸 在 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.33h， 生成 Cbo-glycyl-aminomalonsaeurediethylester
  参考文献：
  名称：

  [EN] PERIPHERALLY RESTRICTED GABA POSITIVE ALLOSTERIC MODULATORS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME AND OTHER AILMENTS OF THE PERIPHERAL NERVOUS SYSTEM
  [FR] MODULATEURS ALLOSTÉRIQUES POSITIFS AU GABA RESTREINTS AU SYSTÈME NERVEUX PÉRIPHÉRIQUE POUR LE TRAITEMENT DU SYNDROME DU CÔLON IRRITABLE ET AUTRES AFFECTIONS DU SYSTÈME NERVEUX PÉRIPHÉRIQUE

  摘要：

  公开号：

  WO2015200766A3

文献信息

• Electron field emission from Ar⁺ ion-treated thick-film carbon paste
  作者：Gillian A. M. Reynolds、Lap-Tak Cheng、Robert Bouchard、Paul Moffett、Howard Jones、Linda F. Robinson、S. Ismat Shah、Daniel I. Amey

  DOI：10.1557/jmr.2002.0375

  日期：2002.10

  Ion bombardment was used to produce electron-emitting microscale features on surfaces of thick films printed with carbon pastes. This technology can potentially enable the development of large-area field emission displays. Systematic investigations using microscopy and electron field emission experiments have demonstrated a close link among paste formulation, ion processing parameters, and the development of surface microstructures. These investigations were also useful in understanding the fundamentals of microstructure formation under ion bombardment and the field emission characteristics of the carbon-based emitters. Several device concepts aimed toward achieving a low-voltage switchable triode were also tested with varying degrees of success. In this paper, we discuss various technological issues related to the materials, processes, and devices.

  利用离子轰击技术在印有碳浆的厚膜表面产生电子发射微观特征。这项技术有可能实现大面积场发射显示器的开发。利用显微镜和电子场发射实验进行的系统研究表明，浆料配方、离子处理参数和表面微结构的发展之间存在密切联系。这些研究还有助于了解离子轰击下微结构形成的基本原理以及碳基发射器的场发射特性。我们还测试了几种旨在实现低压可切换三极管的器件概念，并取得了不同程度的成功。在本文中，我们讨论了与材料、工艺和器件有关的各种技术问题。
• Dipeptides as Leaving Group in the Enzyme-Catalyzed DNA Synthesis
  作者：Xiao-Ping Song、Camille Bouillon、Eveline Lescrinier、Piet Herdewijn

  DOI：10.1002/cbdv.201200261

  日期：2012.12

  polymerases. Although the incorporation efficiency is not very high, it demonstrates that some of these dipeptides can be accommodated in the active site of polymerases and function as leaving groups in the enzymatic synthesis of DNA.

  2'-脱氧腺苷单磷酸与二肽的结合物已经合成，并作为几种聚合酶的底物进行了测试。尽管掺入效率不是很高，但是表明这些二肽中的一些可以被容纳在聚合酶的活性位点中并在DNA的酶促合成中用作离去基团。
• Novel Organic platinum complex and process for the preparation thereof
  申请人：Tanabe Seivaku Co., Ltd.

  公开号：US04886894A1

  公开（公告）日：1989-12-12

  Novel organic platinum complex of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or a lower alkyl group; R.sup.2 is hydrogen atom, a substituted or unsubstituted lower alkyl group, a lower alkenyl group, a lower alkynyl agroup, a lower alkoxy group, a lower alkanoyl group, amino group, a substituted or unsubstituted nitrogen-containing hetero-monocyclic group, or an oxygen-containing hetero-monocyclic group, Alk is a lower alkylene group, X is carbonyl or sulfonyl group, n is 1 or 2, which has excellent anti-tumor activity against various tumors and is useful as an anti-tumor agent, and a process for the preparation thereof, and a pharmaceutical composition containing said compound.

  化合物的化学式为：##STR1## 其中，R.sup.1是氢原子或较低的烷基；R.sup.2是氢原子、取代或未取代的较低烷基、较低烯基、较低炔基、较低烷氧基、较低酰基、氨基、取代或未取代的含氮杂环单环基或含氧杂环单环基，Alk是较低的烷基亚基，X是羰基或磺酰基，n为1或2。该化合物对多种肿瘤具有优异的抗肿瘤活性，可用作抗肿瘤剂，并提供了其制备方法和含有该化合物的制药组合物。
• Novel organic platinum complex pharmaceutical compositions containing same and a process for the preparation thereof
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP0281412A2

  公开（公告）日：1988-09-07

  Novel organic platinum complex of the formula: wherein R¹ is hydrogen atom or a lower alkyl group; R² is hydrogen atom, a substituted or unsubstituted lower alkyl group, a lower alkenyl group, a lower alkynyl agroup, a lower alkoxy group, a lower alkanoyl group, amino group, a substituted or unsubstituted nitrogen-containing hetero-­monocyclic group, or an oxygen-containing hetero-monocyclic group, Alk is a lower alkylene group, X is carbonyl or sulfonyl group, n is 1 or 2, which has excellent anti-tumor activity against various tumors and is useful as an anti-­tumor agent, and a process for the preparation thereof, and a pharmaceutical composition containing said compound.

  式中的新型有机铂络合物： 其中 R¹ 是氢原子或低级烷基；R²是氢原子、取代或未取代的低级烷基、低级烯基、低级炔基、低级烷氧基、低级烷酰基、氨基、取代或未取代的含氮杂单环基团或含氧杂单环基团、Alk为低级亚烷基，X为羰基或磺酰基，n为1或2，对各种肿瘤具有优异的抗肿瘤活性，可用作抗肿瘤剂，及其制备方法，以及含有所述化合物的药物组合物。
• Peripherally restricted GABA positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US10266534B2

  公开（公告）日：2019-04-23

  The present invention provides compounds and compositions which are positive allosteric modulators of GABA-A receptors that selectively target the peripheral nervous system and organs of the body, and which do not pass through the blood-brain barrier. The compounds and compositions of the present invention are useful for treatment of diseases or disorders which are mediated by GABA-A neuronal activity, such as, for example, visceral pain, gut motility, irritable bowel syndrome, functional abdominal pain, functional idiopathic diarrhea, inflammatory bowel diseases, drug induced pain, bile salt malabsorption, lactase or other carbohydrate intolerance.

  本发明提供的化合物和组合物是 GABA-A 受体的正性异位调节剂，可选择性地靶向外周神经系统和人体器官，且不通过血脑屏障。本发明的化合物和组合物可用于治疗由 GABA-A 神经元活性介导的疾病或失调，例如，内脏疼痛、肠道运动、肠易激综合征、功能性腹痛、功能性特发性腹泻、炎症性肠病、药物引起的疼痛、胆盐吸收不良、乳糖酶或其他碳水化合物不耐受。