YK-4-275 | 667914-33-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: YK-4-275
• 英文别名: 4,7-dichloro-3-[2-(4-chlorophenyl-2-oxoethyl)]-3-hydroxyI-1,3-dihydroindol-2-one；4,7-Dichloro-3-(2-(4-chlorophenyl)-2-oxoethyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one；4,7-dichloro-3-[2-(4-chlorophenyl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one
• CAS: 667914-33-2
• 化学式: C₁₆H₁₀Cl₃NO₃
• 分子量: 370.619
• InChiKey: IRLUUOKUJMDTAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,7-二氯吲哚满二酮 、 对氯苯乙酮 在 二乙胺 作用下， 以 甲醇 为溶剂， 以100%的产率得到YK-4-275
  参考文献：
  名称：

  WO2008/83326

  摘要：

  公开号：

文献信息

• [EN] METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS<br/>[FR] MÉTHODES ET COMPOSITIONS PERMETTANT DE TRAITER DES TUMEURS DE LA FAMILLE DU SARCOME D'EWING
  申请人：UNIV GEORGETOWN

  公开号：WO2013155341A1

  公开（公告）日：2013-10-17

  Compounds, compositions and methods relating to EWS-FLIl protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

  提供与EWS-FLIl蛋白抑制剂相关的化合物、组合物和方法。这些化合物在治疗包括Ewing肉瘤家族在内的癌症中具有用途。
• TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY
  申请人：Toretsky Jeffrey A.

  公开号：US20100004179A1

  公开（公告）日：2010-01-07

  Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
• METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS
  申请人：GEORGETOWN UNIVERSITY

  公开号：US20150051260A1

  公开（公告）日：2015-02-19

  Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
• METHODS AND COMPOSITIONS FOR TREATING CANCER
  申请人：GEORGETOWN UNIVERSITY

  公开号：US20160263086A1

  公开（公告）日：2016-09-15

  Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.
• US9045415B2
  申请人：——

  公开号：US9045415B2

  公开（公告）日：2015-06-02