7-oxotridecanoic acid | 92155-72-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-oxotridecanoic acid
• CAS: 92155-72-1
• 化学式: C₁₃H₂₄O₃
• 分子量: 228.332
• InChiKey: OTKAMMQUGUNABV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-oxotridecanoic acid 在 sodium hydroxide 、 一水合肼 、 二乙二醇 作用下， 生成 十三烷二酸
  参考文献：
  名称：

  Huenig; Luecke, Chemische Berichte, 1959, vol. 92, p. 652,660

  摘要：

  DOI：
• 作为产物：
  描述：

  2-Heptanoylcyclohexanone 在 氢氧化钾 作用下， 反应 4.0h， 以80%的产率得到7-oxotridecanoic acid
  参考文献：
  名称：

  Synthesis of the antifungal agent norneoenactin A

  摘要：

  The first total and unequivocal syntheses of (R)- and (S)-norneoenactin A (1), an analog of the antifungal antibiotic neoenactin A, are described. The key step of each synthesis was the Michael addition of a serinehydroxamate (5 or 8) to the appropriate vinyl ketone 4. Biological activity of the two enantiomers of norneoenactin A ((S)-1 and (R)-1) against Escherichia coli and several fungi has been investigated.

  DOI：

  10.1021/jo00074a038

文献信息

• Epicuticular waxes from Agropyron dasystachyum, agropyron riparium and Agropyron elongatum
  作者：Alexander P. Tulloch

  DOI：10.1016/0031-9422(83)80097-1

  日期：1983.1

  2-alkanols. A. dasystachyum wax contains 2% free alcohols, that of A. riparium contains 17% and that of A. elongatum 11% (1-hexacosanol is the major alcohol in each). Diesters (2%), C8C12 diols esterified by (E)-2-alkenoic acids, are present in A. riparium wax. Hentriacontane-14,16-dione is present: 29% in A. dasystachyum wax and 32% in A. riparium wax, but only 5% in A. elongatum wax. 25-Oxohentriacontane-14

  摘要 来自 Agropyron dasystachyum var. 全株的表皮蜡。砂门、A. riparium 和 A. elongatum 含有碳氢化合物 (5–8%)、长链酯 (12–15%) 和游离酸 (2–5%)。主要的酯类是 C34C56 酯，衍生自 C16C30 酸和醇（1-六十二烷醇是主要醇），但也存在 C31、C33 和 C35 酯（3-11%）。后一种酯是C13和C15 2-链烷醇的C18和C20酸酯。A. dasystachyum 蜡含有 2% 的游离醇，A. riparium 蜡含有 17%，A. elongatum 蜡含有 11%（1-六十二烷醇是每种中的主要醇）。A. riparium 蜡中存在二酯 (2%)，即由 (E)-2-链烯酸酯化的 C8C12 二醇。十三烷-14,16-二酮存在：29% 在 A. dasystachyum 蜡中，32% 在 A. riparium
• Ni-Catalyzed Carboxylation of Unactivated Primary Alkyl Bromides and Sulfonates with CO₂
  作者：Yu Liu、Josep Cornella、Ruben Martin

  DOI：10.1021/ja5064586

  日期：2014.8.13

  A Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO2 at atmospheric pressure is described. The method is characterized by its mild conditions and remarkably wide scope without the need for air- or moisture-sensitive reagents, which make it a user-friendly and operationally simple protocol en route to carboxylic acids.
• Reductive Cyclization. A General Method for the Synthesis of 1-Azabicyclo Compounds^1,2
  作者：Nelson J. Leonard、William E. Goode

  DOI：10.1021/ja01168a010

  日期：1950.12
• The influence of the lipophilicity of 7-oxoacyl-l-alanyl-d-isoglutamines on their immunorestoration activity in vivo
  作者：M Sollner、S Pečar、A Štalc

  DOI：10.1016/s0223-5234(97)89858-3

  日期：1996.1

  In search for immunologically active dipeptides, a series of new N-(7-oxoacyl)-L-alanyl-D-isoglutamines has been synthesized where lipophilicity was varied by changing the 7-oxoacyl residue from 7-oxooctanoyl to 7-oxotetradecanoyl. The immunological properties of the compounds were examined in an in vivo immunorestoration test. It was found that lipophilicity had a significant influence on the potency of the compounds tested. Compounds between N-(7-oxodecanoyl)-L-alanyl-D-isoglutamine and N-(7-oxotetradecanoyl)-L-alanyl-D-isoglutamine showed biphasic influence on efficacy. The most active compound found was 7-oxododecanoyl-L-alanyl-D-isoglutamine, which also has an activity comparable to that of azimexone.
• GULACAR, FAZIL O.;BUCHS, ARMAND;SUSINI, ALBERTO, J. CHROMATOGR., 479,(1989) N, C. 61-72
  作者：GULACAR, FAZIL O.、BUCHS, ARMAND、SUSINI, ALBERTO

  DOI：——

  日期：——