1-acetyl-6-fluoroisatin | 715-87-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-acetyl-6-fluoroisatin
• 英文别名: 6-fluoro-1-acetyl indole-2,3-dione；1-acetyl-6-fluoro-indoline-2,3-dione；1-Acetyl-6-fluor-indolin-2,3-dion；1-Acetyl-6-fluoroindole-2,3-dione
• CAS: 715-87-7
• 化学式: C₁₀H₆FNO₃
• 分子量: 207.161
• InChiKey: DVBUSCAWTPVLDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-acetyl-6-fluoroisatin 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 7.0h， 生成 ethyl 1-acetyl-6'-amino-6-fluoro-3'-methyl-2-oxo-1'-phenylspiro[indole-3,4'-pyrano[2,3-c]pyrazole]-5'-carboxylate
  参考文献：
  名称：

  Joshi, Krishna C.; Jain, Renuka; Arora, Seema, Journal of the Indian Chemical Society, 1988, vol. 65, p. 277 - 279

  摘要：

  DOI：
• 作为产物：
  描述：

  6-氟靛红 、 乙酸酐 生成 1-acetyl-6-fluoroisatin
  参考文献：
  名称：

  Holt et al., Journal of the Chemical Society, 1958, p. 1217,1222

  摘要：

  DOI：

文献信息

• FACILE SYNTHESIS OF SOME NEW FLUORINE CONTAINING SPIRO [3H-INDOLE-3,2′TETRAHYDRO-1,3-THIAZINE].2,4′(1H)-DIONES
  作者：Anshu Dandia、C. S. Sharma、Mitali Saha

  DOI：10.1080/10426509808035677

  日期：1998.8.1

  Attempts have been made to synthesize exclusively 5',b'-dihydro-spiro [3H-indol-3,2'-[2H-1,3] thiazine]-2,4'(1H.3'H)-diones (V) under varying reaction conditions such as temperature, reaction period and molar ratio of the two reactants, by the reaction of fluorinated indole-2,3-diones (I) with fluorinated anilines (II) and 3-mercaptopropanoic acid (IV). The reaction of 3-indolylimines (III) with a slight excess of IV at room temperature, resulted in the formation of an acidic compound (VI), instead of expected spiro product (V), which has been further subjected to acetylation and chloroacetylation. The compounds have been characterized on the basis of elemental and spectral studies.
• Joshi, Krishna C.; Jain, Renuka; Dandia, Anshu, Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 1799 - 1802
  作者：Joshi, Krishna C.、Jain, Renuka、Dandia, Anshu、Garg, Saroj、Ahmed, Nidhal

  DOI：——

  日期：——
• Joshi, Krishna C.; Chand, Pooran; Dandia, Anshu, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 8, p. 743 - 745
  作者：Joshi, Krishna C.、Chand, Pooran、Dandia, Anshu

  DOI：——

  日期：——
• Synthesis and mass fragmentation pattern of fluorinated spiro [3H-indole-3.9′-[9H] xanthene]-1′,2,8′ (1H,2′H,5′H)-triones
  作者：Krishna C. Joshi、Renuka Jain、Seema Arora

  DOI：10.1016/s0022-1139(00)82745-1

  日期：1989.2
• Dandia, Anshu; Khanna, Sangeeta; Joshi, Krishna C, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1991, vol. 30, # 5, p. 469 - 472
  作者：Dandia, Anshu、Khanna, Sangeeta、Joshi, Krishna C

  DOI：——

  日期：——