MPPGA

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: MPPGA
• 英文别名: N-(methylphenylphosphonyl)glutamic acid；(2S)-2-[[methoxy(phenyl)phosphoryl]amino]pentanedioic acid
• 化学式: C₁₂H₁₆NO₆P
• 分子量: 301.236
• InChiKey: GXNJJDKOTVYWOC-SMNKDYLDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  苯膦酰二氯 在 钯 四氮唑 、 氢气 、 二乙醇胺 作用下， 生成 MPPGA
  参考文献：
  名称：

  Evaluation of phosphorus-containing inhibitors of γ-glutamyl hydrolase

  摘要：

  Several putative, phosphorus-containing inhibitors of gamma-glutamyl hydrolase were synthesized and evaluated for inhibitory activity. The phosphonamidoic acids were shown to be weak competitive inhibitors while both a phosphoramidate diester and a phosphonamidate ester were shown to be potent time-dependent inactivators, presumably through irreversible phosphorylation of an active site nucleophile. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00253-4

文献信息

• Evaluation of phosphorus-containing inhibitors of γ-glutamyl hydrolase
  作者：Chester E. Rodriguez、H. Michael Holmes、Karyn L. Mlodnosky、Vinh Q. Lam、Clifford E. Berkman

  DOI：10.1016/s0960-894x(98)00253-4

  日期：1998.6

  Several putative, phosphorus-containing inhibitors of gamma-glutamyl hydrolase were synthesized and evaluated for inhibitory activity. The phosphonamidoic acids were shown to be weak competitive inhibitors while both a phosphoramidate diester and a phosphonamidate ester were shown to be potent time-dependent inactivators, presumably through irreversible phosphorylation of an active site nucleophile. (C) 1998 Elsevier Science Ltd. All rights reserved.