1-(propylsulfanyl)pentan-2-ol | 1159011-18-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(propylsulfanyl)pentan-2-ol
• 英文别名: 1-propylsulfanylpentan-2-ol
• CAS: 1159011-18-3
• 化学式: C₈H₁₈OS
• 分子量: 162.296
• InChiKey: KGQOPLKXLCFAEV-UHFFFAOYSA-N

物化性质

• 沸点：
  86-88 °C(Press: 1 Torr)
• 密度：
  0.9396 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  哌啶 、 聚合甲醛 、 1-(propylsulfanyl)pentan-2-ol 以 苯 为溶剂， 以74%的产率得到2-piperidinomethyloxy-1-(propylsulfanyl)pentane
  参考文献：
  名称：

  Synthesis and properties of aminomethyloxy derivatives of (1-Propylsulfanyl)pentane

  摘要：

  New 2-aminomethyloxy derivatives of 1-(propylsulfanyl)pentane were prepared by condensation of 1-(propylsulfanyl)pentan-2-ol with formaldehyde and secondary amines. The starting 1-(propylsulfanyl)pentan-2-ol was synthesized by the reaction of 1-propanethiol with 1-bromopentan-2-ol. The structures of the products were proved by elemental analysis, IR and H-1 NMR spectroscopy, and mass spectrometry. The compounds were tested as antimicrobial additives to lubricating oils and as antiseptics against bacteria and fungi.

  DOI：

  10.1134/s1070427210050174
• 作为产物：
  描述：

  丙烷-1-硫醇 、 1-溴戊烷-2-醇 在 sodium hydroxide 作用下， 以 水 为溶剂， 以66%的产率得到1-(propylsulfanyl)pentan-2-ol
  参考文献：
  名称：

  Synthesis and properties of aminomethyloxy derivatives of (1-Propylsulfanyl)pentane

  摘要：

  New 2-aminomethyloxy derivatives of 1-(propylsulfanyl)pentane were prepared by condensation of 1-(propylsulfanyl)pentan-2-ol with formaldehyde and secondary amines. The starting 1-(propylsulfanyl)pentan-2-ol was synthesized by the reaction of 1-propanethiol with 1-bromopentan-2-ol. The structures of the products were proved by elemental analysis, IR and H-1 NMR spectroscopy, and mass spectrometry. The compounds were tested as antimicrobial additives to lubricating oils and as antiseptics against bacteria and fungi.

  DOI：

  10.1134/s1070427210050174

文献信息

• [EN] MK2 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS MK2 ET UTILISATIONS ASSOCIÉES
  申请人：CELGENE AVILOMICS RES INC

  公开号：WO2014149164A1

  公开（公告）日：2014-09-25

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用方法。
• CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
  申请人：Fresenius Kabi Deutschland GmbH

  公开号：US20150297738A1

  公开（公告）日：2015-10-22

  The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M) n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

  本发明涉及一种羟烷基淀粉共轭物及其制备方法，所述羟烷基淀粉共轭物包括羟烷基淀粉衍生物和细胞毒性药剂，所述细胞毒性药剂包括至少一个次级羟基，其中羟烷基淀粉通过所述次级羟基与细胞毒性药剂连接。根据本发明的共轭物具有以下公式HAS'(-L-M)n的结构，其中M是细胞毒性药剂的残基，L是连接基团，HAS'是羟烷基淀粉衍生物的残基，n大于或等于1，且羟烷基淀粉衍生物的平均分子量（MW）高于肾脏阈值。
• NITRIC OXIDE DELIVERING HYDROXYALKYL STARCH DERIVATIVES
  申请人：Schimmel Martin

  公开号：US20130184237A1

  公开（公告）日：2013-07-18

  The present invention relates to nitric oxide delivering hydroxyalkyl starch derivatives, methods of preparing the same, and specific uses of these hydroxyalkyl starch derivatives.
• Synthesis and properties of aminomethyloxy derivatives of (1-Propylsulfanyl)pentane
  作者：I. A. Dzhafarov、E. G. Mamedbeili、T. G. Kyazimova、Kh. I. Gasanov、E. I. Suleimanova

  DOI：10.1134/s1070427210050174

  日期：2010.5

  New 2-aminomethyloxy derivatives of 1-(propylsulfanyl)pentane were prepared by condensation of 1-(propylsulfanyl)pentan-2-ol with formaldehyde and secondary amines. The starting 1-(propylsulfanyl)pentan-2-ol was synthesized by the reaction of 1-propanethiol with 1-bromopentan-2-ol. The structures of the products were proved by elemental analysis, IR and H-1 NMR spectroscopy, and mass spectrometry. The compounds were tested as antimicrobial additives to lubricating oils and as antiseptics against bacteria and fungi.