2,2''-oxydi-1,1'-biphenyl | 90247-81-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2''-oxydi-1,1'-biphenyl
• 英文别名: biphenyl ether；bis-biphenyl-2-yl ether；Bis-biphenyl-2-yl-aether；biphenylyl ether；Biphenyl-2-yl oxide；1-phenyl-2-(2-phenylphenoxy)benzene
• CAS: 90247-81-7
• 化学式: C₂₄H₁₈O
• 分子量: 322.406
• InChiKey: GMRIWCLJJFNYSC-UHFFFAOYSA-N

物化性质

• 熔点：
  75 °C
• 沸点：
  187 °C(Press: 6 Torr)
• 密度：
  1.1143 g/cm3(Temp: 18 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氯联苯 在 水 、 sodium carbonate 作用下， 生成 2,2''-oxydi-1,1'-biphenyl
  参考文献：
  名称：

  US1972605

  摘要：

  公开号：
• 作为试剂：
  描述：

  6,7,8-三氟-1,4-二氢-4-氧代-3-喹啉羧酸乙酯 在 2,2''-oxydi-1,1'-biphenyl 、 sodium hydroxide 、 三氯氧磷 作用下， 反应 15.8h， 生成 6,7,8-trifluoro-4-chloroquinoline
  参考文献：
  名称：

  Structure–activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1

  摘要：

  A series of 4-anilinoquinoline derivatives related to the known inhibitor SGI-1027, containing side chains of varying pK(a), were prepared by acid-catalysed coupling of the pre-formed side chains with 4-chloroquinolines. The compounds were evaluated for their ability to reduce the level of DNMT1 protein in HCT116 human colon carcinoma cells by Western blotting. With a very strongly basic N-methylpyridinium side chain, only NHCO-linked compounds were effective, whereas less strongly basic ((diaminomethylene) hydrazono)ethyl or 3-methylpyrimidine-2,4-diamine side chains allowed both NHCO- and CONH-linked compounds to show activity. In contrast, the pK(a) of the quinoline unit had little apparent influence on activity. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.03.033

文献信息

• COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S)
  申请人：SCHMAUS Gerhard

  公开号：US20160008297A1

  公开（公告）日：2016-01-14

  The present invention primarily relates to the use of one or more specific compounds and/or one or more respective salt(s) thereof for preventing, reducing or alleviating itchy skin condition(s), and/or as PAR-2 antagonist. Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, in particular for preventing, reducing or alleviating one or more itchy skin conditions and/or for providing a PAR-2 antagonistic effect, comprising or consisting of an effect amount of such compound(s) and/or salt(s) and one or more cosmetically and/or pharmaceutically acceptable carriers.

  本发明主要涉及使用一种或多种特定化合物和/或其一个或多个相应盐来预防、减少或缓解瘙痒皮肤状况，和/或作为PAR-2拮抗剂。此外，本发明涉及组合物（产品或相应的配方），特别是用于局部给药，优选为化妆品或药用组合物，特别是用于预防、减少或缓解一种或多种瘙痒皮肤状况和/或产生PAR-2拮抗作用的组合物，包括或由效果量的这种化合物和/或盐以及一个或多个化妆品和/或药用可接受载体组成。
• ETHYNYLPHENYLAMIDINE COMPOUND OR SALT THEREOF, METHOD FOR PRODUCING SAME, AND FUNGICIDE FOR AGRICULTURAL AND HORTICULTURAL USE
  申请人：Masumoto Satoru

  公开号：US20130217884A1

  公开（公告）日：2013-08-22

  An object of the present invention is to provide a novel fungicide having an excellent fungicidal activity. The compound used as the fungicide of the present invention is an ethynylphenylamidine compound or a salt thereof, the compound being represented by Formula (1): wherein R 1 and R 2 are each hydrogen or C 1-12 alkyl, or R 1 and R 2 may be bonded together to form C 1-7 alkylene; R 3 is hydrogen or C 1-4 alkylthio; R 4 , R 5 , R 6 , and R 7 are each hydrogen, halogen, etc.; and R 8 is hydrogen, C 1-20 alkyl, C 3-8 cycloalkyl, C 1-4 haloalkyl, phenyl, a heterocyclic group, or —(CH 2 )n-Si(R 9 )(R 10 )(R 11 ) wherein R 9 , R 10 , and R 11 are each C 1-6 alkyl, and n is an integer of 0 or 1.

  本发明的目的是提供一种具有优良杀真菌活性的新型杀菌剂。本发明所使用的杀菌剂化合物是一种乙炔基苯胺化合物或其盐，该化合物由式（1）表示：其中R1和R2分别是氢或C1-12烷基，或R1和R2可以结合在一起形成C1-7烷基烯；R3是氢或C1-4烷基硫；R4、R5、R6和R7分别是氢、卤素等；R8是氢、C1-20烷基、C3-8环烷基、C1-4卤代烷基、苯基、杂环基，或—(CH2)n-Si(R9)(R10)(R11)，其中R9、R10和R11分别是C1-6烷基，n是0或1的整数。
• Synthesis of benzannulated heterocycles by twofold Suzuki–Miyaura couplings of cyclic diarylborinic acids
  作者：Elena Dimitrijević、Madeline Cusimano、Mark S. Taylor

  DOI：10.1039/c3ob42065e

  日期：——

  Two-fold Suzuki–Miyaura cross-couplings of cyclic diarylborinic acids are described. This novel annulation method enables the synthesis of benzo-fused heterocycles from dihaloarenes or gem-dibromoolefins.

  描述了循环二芳基硼酸的双重铃木–宫浦交叉偶联。这种新颖的闭环方法使得从二氯芳烃或共二溴烯烃合成苯并融合杂环成为可能。
• Sur la déshydratation catalytique des phénols; Influence de la nature et de la position des groupes substitués
  作者：E. Briner、A.-A. Bron

  DOI：10.1002/hlca.193201501140

  日期：——

  La déshydratation catalytique, sur la thorine, des phénols en oxydes a été réalisée avec des rendements qui ont été établis pour les crésols, les xylénols, les phényl-phénols, le gaïacol, les α- et le β-naphtols; dans le cas des naphtols, la déshydratation est accompagnée d'une déshydrogénation assez marquée (production d'oxydes de naphtylène).

  苯磺酸盐的脱水催化，苯酚的氧化，苯酚的氧化还原，苯酚的氧化，苯酚的苯基，苯酚的α，萘酚的; dans le cas des naphtols，déshydroatationestaccompagnéed'unedéshydrogénationassezmarquée（生产d'oxydes denaphtylène）。
• 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone and its use in cosmetic and pharmaceutical preparations
  申请人：Schmaus Gerhard

  公开号：US20090208434A1

  公开（公告）日：2009-08-20

  The present invention concerns applications of the compound of formula 1 in cosmetic or pharmaceutical preparations.

  本发明涉及化合物1的在化妆品或药物制剂中的应用。