3,3-dimethoxy-2-oxo-propanal

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,3-dimethoxy-2-oxo-propanal
• 英文别名: 3,3-dimethoxy-2-oxopropanal；3,3-Dimethoxy-2-oxopropanal
• 化学式: C₅H₈O₄
• 分子量: 132.116
• InChiKey: NOUNRWWJSPOXRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,3-dimethoxy-2-oxo-propanal 在 4-二甲氨基吡啶 、 sodium sulfite 作用下， 以 水 为溶剂， 生成 N-[6-(dimethoxymethyl)-4-oxo-3H-pteridin-2-yl]-2,2-dimethylpropanamide
  参考文献：
  名称：

  Pterin-based highly selective, ratiometric, and sensitive ‘naked-eye’ sensor for acetate

  摘要：

  The design and synthesis of a new pterin-based ratiometric and sensitive 'naked-eye' sensor R for highly selective recognition of acetate are reported. The acidic lactam NH and the NH of 2-N-pivaloyl group of receptor R along with 2,4-dinitrophenyl hydrazone group having the other acidic NH moiety lead to the binding of acetate anion in a 1:2 ratio by change of spectroscopic behavior on complexation (UV-vis and H-1 NMR studies) which is also proven by job plot. The sharp color change from light yellow to violet promises R to be a useful chromogenic ratiometric sensor for acetate amongst other common anions. (C) 2014 Elsevier Ltd. All rights reserved,

  DOI：

  10.1016/j.tetlet.2014.03.068
• 作为产物：
  描述：

  1,1-二甲氧基丙酮 在 selenium(IV) oxide 作用下， 以 1,4-二氧六环 为溶剂， 生成 3,3-dimethoxy-2-oxo-propanal
  参考文献：
  名称：

  A simple quinoxaline-based highly sensitive colorimetric and ratiometric sensor, selective for nickel and effective in very high dilution

  摘要：

  A new quinoxaline based receptor (HQNM) has been designed and synthesized which shows a remarkable color change from colorless to yellow on specific binding with nickel. The cation recognition property of the receptor is monitored by the UV-vis and H-1 NMR titrations. It is observed that the receptor shows a specific selectivity toward nickel over other interfering cations. Thus, a significant bathochromic shift in UV-vis spectrum with a sharp yellow color in 'naked-eye' makes the receptor suitable for the easy detection of nickel ion. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.051

文献信息

• The Smallest Vicinal Tricarbonyl Compound as a Monohydrate and Tetracarbonyl Compound as a Thiane Derivative - First Effective Synthesis, Characterization and Chemistry
  作者：Shyamaprosad Goswami、Annada C. Maity、Hoong-Kun Fun、Suchada Chantrapromma

  DOI：10.1002/ejoc.200801050

  日期：2009.3

  The synthesis of a series of protected as well as free heterocyclic aldehydes (pterins and quinoxalines) by the use of the appropriate tricarbonyl compounds is also reported. Additionally, a one-step synthetic strategy to prepare a series of different biheterocycles with the smallest vicinal tetracarbonyl compound is demonstrated.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

  报道了 2-oxo-1,3-propanedial 一水合物或 mesoxaldehyde (6a) 的有效合成和 2,3-dioxo-1,4-butanedial (18) 作为噻烷衍生物的首次合成。最小的邻位三和四羰基化合物的这些第一成员通过转化为噻烷衍生物 8、9、10、11、12、15 和 19 来稳定，这些衍生物可以在室温下作为长寿命化合物分离。这些新型噻烷 8、10、12 和 15 的结构通过它们的 X 射线晶体结构得到证实。还报道了使用适当的三羰基化合物合成一系列受保护和游离的杂环醛（蝶呤和喹喔啉）。此外，还展示了用最小的邻位四羰基化合物制备一系列不同二杂环的一步合成策略。
• Pterin-based highly selective, ratiometric, and sensitive ‘naked-eye’ sensor for acetate
  作者：Shyamaprosad Goswami、Manas Kumar Das、Abhishek Manna

  DOI：10.1016/j.tetlet.2014.03.068

  日期：2014.4

  The design and synthesis of a new pterin-based ratiometric and sensitive 'naked-eye' sensor R for highly selective recognition of acetate are reported. The acidic lactam NH and the NH of 2-N-pivaloyl group of receptor R along with 2,4-dinitrophenyl hydrazone group having the other acidic NH moiety lead to the binding of acetate anion in a 1:2 ratio by change of spectroscopic behavior on complexation (UV-vis and H-1 NMR studies) which is also proven by job plot. The sharp color change from light yellow to violet promises R to be a useful chromogenic ratiometric sensor for acetate amongst other common anions. (C) 2014 Elsevier Ltd. All rights reserved,
• A simple quinoxaline-based highly sensitive colorimetric and ratiometric sensor, selective for nickel and effective in very high dilution
  作者：Shyamaprosad Goswami、Shampa Chakraborty、Sima Paul、Sandipan Halder、Annada C. Maity

  DOI：10.1016/j.tetlet.2013.07.051

  日期：2013.9

  A new quinoxaline based receptor (HQNM) has been designed and synthesized which shows a remarkable color change from colorless to yellow on specific binding with nickel. The cation recognition property of the receptor is monitored by the UV-vis and H-1 NMR titrations. It is observed that the receptor shows a specific selectivity toward nickel over other interfering cations. Thus, a significant bathochromic shift in UV-vis spectrum with a sharp yellow color in 'naked-eye' makes the receptor suitable for the easy detection of nickel ion. (C) 2013 Elsevier Ltd. All rights reserved.