bis(S-ethyl-2-thiosalicylate)palladium(II) | 1352720-09-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: bis(S-ethyl-2-thiosalicylate)palladium(II)
• 英文别名: bis[(S-ethyl)thiosalicylate]palladium(II)；[Pd(S-et-thiosal)₂]；2-Ethylsulfanylbenzoate;palladium(2+)
• CAS: 1352720-09-2
• 化学式: C₁₈H₁₈O₄PdS₂
• 分子量: 468.891
• InChiKey: SZHLLMSQGVZULV-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  2.32
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  131
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  硫代水杨酸 在 sodium hydroxide 、 lithium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 生成 bis(S-ethyl-2-thiosalicylate)palladium(II)
  参考文献：
  名称：

  Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)2]

  摘要：

  The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)(2)] consists of neutral complex molecules, where the Pd(II) ion is placed in a cis-square-planar coordination environment formed by O and S atoms of two deprotonated S-butyl-thiosalicylic acid ligands. The cytotoxic effects of the S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding palladium(II) complexes are reported here. The analysis of cancer cell viability showed that all the tested complexes are cytotoxic to human colon carcinoma cells (HCT-116 and CaCo-2) and human lung carcinoma epithelial cells (A549). The antitumor activities of the above mentioned Pd(II) complexes are higher in comparison to the corresponding ligands. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2015.01.041

文献信息

• Synthesis, characterization and antimicrobial activity of palladium(II) complexes with some alkyl derivates of thiosalicylic acids: Crystal structure of the bis(S-benzyl-thiosalicylate)–palladium(II) complex, [Pd(S-bz-thiosal)2]
  作者：Gordana P. Radić、Verica V. Glođović、Ivana D. Radojević、Olgica D. Stefanović、Ljiljana R. Čomić、Zoran R. Ratković、Arto Valkonen、Kari Rissanen、Srećko R. Trifunović

  DOI：10.1016/j.poly.2011.08.042

  日期：2012.1

  S-Alkyl (R = benzyl, methyl, ethyl, propyl and butyl) derivatives of thiosalicylic acid and the corresponding palladium(II) complexes were prepared and their structures were proposed on the basis of infrared, H-1 and C-13 NMR spectroscopy. The cis geometrical configurations of the isolated complexes were proposed on the basis of an X-ray structural study of the bis(S-benzyl-thiosalicylate)-palladium(II), [Pd(S-bz-thiosal)(2)] complex.Antimicrobial activity of the tested compounds was evaluated by determining the minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) in relation to 26 species of microorganisms. The tested ligands, with a few exceptions, show low antimicrobial activity. The palladium(II) complexes, [Pd(S-R-thiosal)(2)], have statistically significant higher activity than the corresponding ligands. The complexes [Pd(S-et-thiosal)(2)] and [d(S-pro-thiosal)(2)] displayed the strongest activity amongst the all tested compounds. The palladium(II) complexes show selective and moderate antibacterial activity and significant antifungal activity. The most sensitive were Aspergillus fumigants and Aspergillus flavus. (C) 2011 Elsevier Ltd. All rights reserved.