(3,5-Di-tert-butyl-4-hydroxy-phenyl)-(3,4,5-trimethoxy-benzylamino)-acetic acid ethyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3,5-Di-tert-butyl-4-hydroxy-phenyl)-(3,4,5-trimethoxy-benzylamino)-acetic acid ethyl ester
• 英文别名: Ethyl 2-(3,5-ditert-butyl-4-hydroxyphenyl)-2-[(3,4,5-trimethoxyphenyl)methylamino]acetate
• 化学式: C₂₈H₄₁NO₆
• 分子量: 487.637
• InChiKey: BLKNSIVSXKVAOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,6-二叔丁基苯酚 在 palladium on activated charcoal 三氯化铝 、 氢气 、 三乙酰氧基硼氢化钠 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 32.0h， 生成 (3,5-Di-tert-butyl-4-hydroxy-phenyl)-(3,4,5-trimethoxy-benzylamino)-acetic acid ethyl ester
  参考文献：
  名称：

  Inhibitors of lipoprotein(a) assembly

  摘要：

  Compounds of the general structure A and B were investigated for their activity as lipoprotein(a), [Lp(a)], assembly (coupling) inhibitors. SAR around the amino acid derivatives (structure A) gave compound 14-6 as a potent coupling inhibitor. Oral closing of compound 14-6 to Lp(a) transgenic mice and cymologous monkeys resulted in a > 30% decrease in plasma Lp(a) levels after 1-2 weeks of treatment at 100 mg/kg/day.) (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2002.04.001

文献信息

• US6017918A
  申请人：——

  公开号：US6017918A

  公开（公告）日：2000-01-25
• Inhibitors of lipoprotein(a) assembly
  作者：Karen E Sexton、Helen T Lee、Mark Massa、Janak Padia、William C Patt、Peggy Liao、Jason K Pontrello、Bruce D Roth、Mark A Spahr、Randy Ramharack

  DOI：10.1016/j.bmc.2002.04.001

  日期：2003.11

  Compounds of the general structure A and B were investigated for their activity as lipoprotein(a), [Lp(a)], assembly (coupling) inhibitors. SAR around the amino acid derivatives (structure A) gave compound 14-6 as a potent coupling inhibitor. Oral closing of compound 14-6 to Lp(a) transgenic mice and cymologous monkeys resulted in a > 30% decrease in plasma Lp(a) levels after 1-2 weeks of treatment at 100 mg/kg/day.) (C) 2003 Elsevier Ltd. All rights reserved.