calcium glucarate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: calcium glucarate
• 英文别名: D-Saccharic acid calcium salt；calcium;2,3,4,5-tetrahydroxyhexanedioate
• 化学式: C₆H₈O₈*Ca
• 分子量: 248.203
• InChiKey: UGZVNIRNPPEDHM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -6.45
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  calcium glucarate 在 盐酸 、 zinc(II) chloride 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以68%的产率得到2,5-呋喃二甲酸
  参考文献：
  名称：

  [EN] NOVEL PROCESSES FOR PREPARATION OF 2,5-FURANDICARBOXYLIC ACID
  [FR] NOUVEAUX PROCÉDÉS DE PRÉPARATION D'ACIDE 2,5-FURANDICARBOXYLIQUE

  摘要：

  本公开提供了从各种底物制备2,5-呋喃二甲酸（FDCA）的工艺，包括C6-醛糖酸和C6-醛糖酸内酯。

  公开号：

  WO2019014393A1

文献信息

• NOVEL FORMULATION OF DEHYDRATED LIPID VESICLES FOR CONTROLLED RELEASE OF ACTIVE PHARMACEUTICAL INGREDIENT VIA INHALATION
  申请人：Yang Zhijun

  公开号：US20090047336A1

  公开（公告）日：2009-02-19

  A new formulation of dehydrated lipid vesicles employs a vesicle preserver and permits the control of release and delivery of active pharmaceutical ingredients into the respiratory system for treatment in particular of asthma. The typical formulation provides controlled release of the active pharmaceutical ingredient from 0% to 100% from 0 to 72 hours after inhalation, changes the systemic administration to topical administration, allows prolonged therapeutic period for one administration, increased stability, with reduced dose, reduced systemic side effects, reduced toxicity.

  一种新的脱水脂质囊泡配方采用了囊泡保护剂，允许控制将活性药物成分释放和传递到呼吸系统，特别用于治疗哮喘。典型的配方提供了从吸入后0到72小时内活性药物成分的控制释放，将全身给药改为局部给药，允许单次给药的延长治疗期，增加稳定性，减少剂量，减少全身副作用，减少毒性。
• [EN] PROCESS FOR PREPARING D-GLUCARO-6,3-LACTONE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE D-GLUCARO-6,3-LACTONE
  申请人：BASF SE

  公开号：WO2018146122A1

  公开（公告）日：2018-08-16

  The presently claimed invention is directed to a process for preparing D-glucaro-6,3-lactone from a salt of D-glucaric acid.

  目前所宣称的发明涉及从葡萄糖酸盐制备D-葡萄糖醛-6,3-内酯的过程。
• Wound dressings, methods and apparatus for making same and storage and use thereof
  申请人：REDDRESS LTD.

  公开号：US10111979B2

  公开（公告）日：2018-10-30

  Provided is a wound dressing prepared from whole blood that is clotted ex vivo to form a sheet of clotted blood that is applied onto the skin over a sight of skin injury.

  本发明提供了一种伤口敷料，该敷料由全血制备而成，全血在体内凝结成凝血片，敷在皮肤损伤部位的皮肤上。
• Calcium gluconate solutions in flexible containers
  申请人：HQ SPECIALTY PHARMA CORPORATION

  公开号：US10130646B1

  公开（公告）日：2018-11-20

  A terminally sterilized aqueous calcium gluconate solution comprising 1 to 15 wt. % calcium gluconate and from 1 to 19 wt. parts of calcium saccharate per 100 wt. parts of calcium gluconate packaged in a flexible plastic container with the remainder water.

  经最终灭菌的葡萄糖酸钙水溶液，每 100 重量份葡萄糖酸钙含 1 至 15 重量份葡萄糖酸钙和 1 至 19 重量份糖酸钙，用软质塑料容器包装，其余为水。
• Process for preparing D-glucaro-6,3-lactone
  申请人：BASF SE

  公开号：US10774058B2

  公开（公告）日：2020-09-15

  A process for preparing D-glucaro-6,3-lactone from a salt of D-glucaric acid is provided. The process includes: adding a mineral acid to a pre-cooled solution including a salt of D-glucaric acid, water, and acetone to obtain a crude mixture; allowing the crude mixture to rise to a temperature in a range of ≥15° C. to ≤35° C. and stirring the crude mixture; filtrating the crude mixture and washing with an acetone and water solvent mixture to obtain a filtrate; concentrating the filtrate under vacuum pressure to obtain a concentrated filtrate having a water content in a range of ≥20.0 wt. % to ≤40.0 wt. %, relative to an overall weight of the concentrated filtrate; storing the concentrated filtrate at a temperature in a range of ≥0° C. to ≤5° C., and optionally repeating the concentrating and storing steps to obtain a precipitate comprising D-glucaro-6,3-lactone.

  本发明提供了一种从 D-葡萄糖酸盐制备 D-葡萄糖-6,3-内酯的工艺。该工艺包括：向包括 D-葡糖酸盐、水和丙酮的预冷溶液中加入矿物酸，以获得粗混合物；使粗混合物升温至 ≥15°C 至 ≤35°C 范围内的温度，并搅拌粗混合物；过滤粗混合物，并用丙酮和水洗涤粗混合物。搅拌粗混合物； 过滤粗混合物并用丙酮和水溶剂混合物洗涤，得到滤液； 在真空压力下浓缩滤液，得到浓缩滤液，相对于浓缩滤液的总重量，浓缩滤液的含水量在 ≥20.0 重量百分比到 ≤40.0 重量百分比之间； 将浓缩滤液储存在温度为 ≥0°C 到 ≤5°C 的范围内、并选择性地重复浓缩和储存步骤，以获得包含 D-葡萄糖-6,3-内酯的沉淀物。