N-((4-氧代)-1-戊基)乙酰胺 | 17636-95-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-((4-氧代)-1-戊基)乙酰胺
• 中文别名: 乙酰胺,N-(4-羰基戊基)-
• 英文名称: N-(4-oxopentyl)acetamide
• CAS: 17636-95-2
• 化学式: C₇H₁₃NO₂
• mdl: MFCD13248879
• 分子量: 143.186
• InChiKey: HJSYCVYFTIIOPM-UHFFFAOYSA-N

物化性质

• 熔点：
  48-50 °C
• 沸点：
  322.9±25.0 °C(Predicted)
• 密度：
  0.973±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-((4-氧代)-1-戊基)乙酰胺 在 草酰氯 、 对甲苯磺酸 、 二甲基亚砜 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 20.5h， 生成 N-(2-(2-formyl-1-methyl-1H-indol-3-yl)ethyl)acetamide
  参考文献：
  名称：

  A one-pot three-component reaction for the preparation of highly functionalized tryptamines

  摘要：

  We have developed a general one-pot method to provide highly functionalized tryptamine derivatives, via a Fischer indole type pathway. In this article, we demonstrate optimal conditions for a one-pot indole synthesis, allowing for the synthesis of a broad scope of 2-methyl tryptamine derivatives and a precursor for the synthesis of the core structure of some akuammiline alkaloids. Additionally, further modification of the indole products is described. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2011.11.032
• 作为产物：
  描述：

  N-(4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-4-hydroxybutyl)acetamide 以 水 、 甲苯 为溶剂， 反应 21.0h， 生成 N-((4-氧代)-1-戊基)乙酰胺
  参考文献：
  名称：

  用于体内捕获聚酮化合物中间体的光活化小分子探针。

  摘要：

  设计并制备了一种光不稳定的卡巴（脱硫）丙二酰基 N-乙酰半胱胺衍生物，用于在光激活后捕获生物合成聚酮化合物中间体。从土壤细菌拉萨链霉菌突变株中的拉沙里菌素 A 聚酮化合物组装中，鉴定并表征了以前未检测到的环化中间体，为底物处理的时间安排提供了新的前景。

  DOI：

  10.1002/chem.201903661

文献信息

• Second-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assembly
  作者：Ina Wilkening、Silvia Gazzola、Elena Riva、James S. Parascandolo、Lijiang Song、Manuela Tosin

  DOI：10.1039/c6cc04681a

  日期：——

  Novel chemical probes provide kinetic insights into polyketide assembly.

  新型化学探针提供了对聚酮化合物组装的动力学见解。
• DIACYLETHYLENEDIAMINE COMPOUND
  申请人：Kawano Tomoaki

  公开号：US20120046292A1

  公开（公告）日：2012-02-23

  [Problem] A compound which is useful as an anti-obesity agent is provided. [Means for Solution] The present inventors have investigated a compound having a DGAT1 inhibitory action, which is promising as an active ingredient of a pharmaceutical composition for treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases, and as a result, they have found that the diacylethylenediamine compound of the present invention has an excellent DGAT1 inhibitory action, thereby completing the present invention. That is, the diacylethylenediamine compound of the present invention has a DGAT1 inhibitory action, and can be therefore used as an agent for preventing and/or treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases.

  提供一种作为抗肥胖剂的化合物。现发明人调查了一种具有DGAT1抑制作用的化合物，该化合物有望成为治疗肥胖、2型糖尿病、脂肪肝以及与这些疾病相关的疾病的药物组合物的有效成分，并且他们发现了本发明的二酰乙二胺化合物具有出色的DGAT1抑制作用，从而完成了本发明。也就是说，本发明的二酰乙二胺化合物具有DGAT1抑制作用，因此可用作预防和/或治疗肥胖、2型糖尿病、脂肪肝以及与这些疾病相关的药物。
• Nitrogen-containing heterocyclic compound and use thereof
  申请人：Ikeura Yoshinori

  公开号：US20090156572A1

  公开（公告）日：2009-06-18

  The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R 1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group, a heterocyclic group optionally having substituent(s) or an amino group optionally having substituent(s), R 2 is an optionally halogenated C 1-6 alkyl group, m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof and the like. Since the compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, gastrointestinal diseases, central nervous system diseases and the like.

  本发明涉及一种由下式表示的化合物：其中环A是含氮杂环，可选择地进一步具有取代基，环B是芳香环，可选择地具有取代基，环C是环状基团，可选择地具有取代基，R1是氢原子，一个碳氢基团，可选择地具有取代基，酰基，一个杂环基团，可选择地具有取代基或一个氨基团，可选择地具有取代基，R2是可选择卤代的C1-6烷基基团，m和n分别是0到5的整数，m+n是2到5的整数，是单键或双键，或其盐等。由于该化合物具有优越的催吐肽受体拮抗作用，可用作预防或治疗多种疾病的药物，如下尿道疾病、胃肠道疾病、中枢神经系统疾病等。
• RUTHENIUM COMPLEXES AND THEIR USES AS CATALYSTS IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND RELATED REACTIONS
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20170283447A1

  公开（公告）日：2017-10-05

  The present invention relates to novel Ruthenium complexes of formulae A1-A4 and their use, inter alia, for (1) dehydrogenative coupling of alcohols to esters; (2) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (3) preparing amides from alcohols and amines—(including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or polymerization of amino alcohols and/or forming cyclic dipeptides from p-aminoalcohols; (4) hydrogenation of amides (including cyclic dipeptides, polypeptides and polyamides) to alcohols and amines; (5) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (6) dehydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water and a base to form carboxylic acids; and (10) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. The present, invention further relates to the use of certain known Ruthenium complexes for the preparation of amino acids or their salts from amino alcohols.

  本发明涉及新型A1-A4式钌配合物及其用途，包括（1）醇的脱氢偶联制备酯；（2）酯的加氢制备醇（包括环酯（内酯）或环二酯（二内酯）的加氢，或聚酯的加氢）；（3）从醇和胺制备酰胺（包括通过二醇和二胺反应或氨基醇的聚合形成聚酰胺（例如，多肽），或从p-氨基醇形成环二肽）；（4）酰胺的加氢（包括环二肽、多肽和聚酰胺的加氢至醇和胺）；（5）有机碳酸酯（包括聚碳酸酯）的加氢至醇或羰基酸酯（包括聚羰基酸酯）或脲衍生物的加氢至醇和胺；（6）次级醇的脱氢至酮；（7）酯的酰胺化（即通过酯和胺合成酰胺）；（8）使用酯对醇进行酰化；（9）醇与水和碱的偶联形成羧酸；以及（10）通过氨基醇与水和碱的偶联制备氨基酸或其盐。本发明还涉及使用某些已知的钌配合物从氨基醇制备氨基酸或其盐。
• Convenient synthesis of melatonin analogues: 2- and 3-substituted -N-acetylindolylalkylamines
  作者：Valentine G. Nenajdenko、Eugene P. Zakurdaev、Eugene V. Prusov、Elizabeth S. Balenkova

  DOI：10.1016/j.tet.2004.10.006

  日期：2004.12

  A new method for the synthesis of 2- and 3-substituted indolylalkylamides, derivatives of melatonin, from arylhydrazines and amidoketones by the Fischer reaction was elaborated. The amidoketones can be easily prepared from cyclic imines by reaction with acylpyridinium chloride. This method is a one-step synchronous creation of the selected alkylamide fragment and the indole core. Variation of the arylhydrazines

  阐述了一种通过费歇尔反应从芳基肼和酰胺酮合成褪黑激素衍生物的2-和3-取代的吲哚基烷基酰胺的新方法。通过与酰化吡啶鎓氯化物反应，可以容易地由环状亚胺制备酰胺酮。该方法是一步一步同步创建所选的烷基酰胺片段和吲哚核。的芳基肼的变化创造indolylalkylamides和酰胺酮的合适的选择可以直接酰胺烷基链的吲哚的2位或3位的碳环所需的取代基。