6-bromo-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime | 1435396-32-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-bromo-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime
• 英文别名: 1-[6-bromo-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]-N-prop-2-ynoxymethanimine
• CAS: 1435396-32-9
• 化学式: C₁₈H₁₄BrN₃O
• 分子量: 368.233
• InChiKey: GAONQRQGGLANOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.06
• 重原子数：
  23.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  38.89
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  6-bromo-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime 、 4-甲氧基溴苄 在 copper(l) iodide 、 sodium azide 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以84%的产率得到6-bromo-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime
  参考文献：
  名称：

  Facile synthesis of new imidazo[1,2-a]pyridines carrying 1,2,3-triazoles via click chemistry and their antiepileptic studies

  摘要：

  The present article reports the synthesis and anticonvulsant studies of new 2-arylimidazo[1,2-a]pyridines carrying suitably substituted 1,2,3-triazoles as well as their intermediates. The structures of newly synthesized compounds were confirmed by various spectroscopic techniques. The anticonvulsant study was carried out by MES and scPTZ screening methods, while their toxicity study was performed following Rotarod method. The active compounds showed enhanced seizure control in scPTZ method when compared with that of MES method. Compounds 3f, 4c, 4f, 5k, 5p and 5w carrying active pharmacophores exhibited complete protection against seizure and their results were comparable with standard drug diazepam. Majority of new compounds were found to be non-toxic, while few of them showed toxicity at 100 mg/kg. The c log P values of target compounds are in the range of 3.5-5.3, which confirm their lipophilic nature. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.03.086
• 作为产物：
  描述：

  6-溴-2-(4-甲基苯基)咪唑并[1,2-a]吡啶 在 硫酸 、 盐酸羟胺 、 potassium carbonate 、 三氯氧磷 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 生成 6-bromo-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime
  参考文献：
  名称：

  Facile synthesis of new imidazo[1,2-a]pyridines carrying 1,2,3-triazoles via click chemistry and their antiepileptic studies

  摘要：

  The present article reports the synthesis and anticonvulsant studies of new 2-arylimidazo[1,2-a]pyridines carrying suitably substituted 1,2,3-triazoles as well as their intermediates. The structures of newly synthesized compounds were confirmed by various spectroscopic techniques. The anticonvulsant study was carried out by MES and scPTZ screening methods, while their toxicity study was performed following Rotarod method. The active compounds showed enhanced seizure control in scPTZ method when compared with that of MES method. Compounds 3f, 4c, 4f, 5k, 5p and 5w carrying active pharmacophores exhibited complete protection against seizure and their results were comparable with standard drug diazepam. Majority of new compounds were found to be non-toxic, while few of them showed toxicity at 100 mg/kg. The c log P values of target compounds are in the range of 3.5-5.3, which confirm their lipophilic nature. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.03.086