3-chloro-2,5-dihydroxy-[1,4]benzoquinone | 26361-22-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-chloro-2,5-dihydroxy-[1,4]benzoquinone
• 英文别名: 3-Chlor-2,5-dihydroxy-[1,4]benzochinon；3-Chlor-2.5-dioxy-chinon；3-Chloro-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione；3-chloro-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
• CAS: 26361-22-8
• 化学式: C₆H₃ClO₄
• 分子量: 174.54
• InChiKey: LCAGQCBFWAVISC-UHFFFAOYSA-N

物化性质

• 沸点：
  307.5±42.0 °C(Predicted)
• 密度：
  1.80±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-chloro-2,5-dihydroxy-[1,4]benzoquinone 在 水 、 sodium acetate 作用下， 生成 2-acetoxy-4-chloro-phenoxazin-3-one
  参考文献：
  名称：

  Kehrmann; Messinger, Chemische Berichte, 1893, vol. 26, p. 2376

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二氯-1,4-苯醌 在 potassium carbonate 作用下， 生成 3-chloro-2,5-dihydroxy-[1,4]benzoquinone
  参考文献：
  名称：

  Cytokine Responses to Recombinant Cholera Toxin B Subunit Produced byBacillus brevisas a Mucosal Adjuvant

  摘要：

  AbstractWe attempted to clarify the mechanism of the mucosal adjuvanticity of recombinant cholera toxin B subunit (rCTB), which is inherently uncontaminated with the holotoxin produced by Bacillus brevis and has a powerful mucosal adjuvant activity, on cytokine responses compared with that of cholera toxin (CT). rCTB had no ability to stimulate cyclic AMP formation in mouse peritoneal macrophages (Mφ). Cytokine production by non‐immunized Mφ cultured with rCTB or CT and by the spleen cells of mice co‐immunized intranasally with ovalbumin (OVA) and rCTB or CT was examined. rCTB alone did not induce interleukin (IL)‐1α/β or IL‐6 production by Mφ, but combination of rCTB with lipopolysaccharide (LPS) enhanced both IL‐1α/β production. Conversely, CT plus LPS suppressed IL‐1α/β production more than LPS alone. Both rCTB and CT suppressed IL‐12 secretion induced by interferon γ (IFN γ) plus LPS. IL‐2, IL‐4, IL‐5, and IL‐10 were secreted by mouse spleen cells restimulated with OVA after intranasal co‐administration of OVA together with rCTB, and in response to CT, the same cytokines were secreted. The different effect of rCTB on Mφ from that of CT may mean a difference between the mechanisms of rCTB and CT during the early stage of an immune response.

  DOI：

  10.1111/j.1348-0421.2001.tb01276.x

文献信息

• Lindberg, Acta Chemica Scandinavica (1947), 1952, vol. 6, p. 1048,1050
  作者：Lindberg

  DOI：——

  日期：——
• Kehrmann, Chemische Berichte, 1890, vol. 23, p. 904
  作者：Kehrmann

  DOI：——

  日期：——
• Kehrmann; Tiesler, Journal fur praktische Chemie (Leipzig 1954), 1890, vol. <2> 41, p. 90
  作者：Kehrmann、Tiesler

  DOI：——

  日期：——
• Kehrmann, Chemische Berichte, 1890, vol. 23, p. 2453
  作者：Kehrmann

  DOI：——

  日期：——
• Kehrmann, Chemische Berichte, 1895, vol. 28, p. 355
  作者：Kehrmann

  DOI：——

  日期：——