4,4'-[1,9-壬烷二基二(氧基)]二苯甲醛 | 87367-64-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4,4'-[1,9-壬烷二基二(氧基)]二苯甲醛
• 英文名称: 1,9-bis-(4'-formylphenoxy)-n-nonane
• 英文别名: 1,9-bis(4-formylphenoxy)nonane；4.4'-Diformyl-α.ω-diphenoxy-nonan；4-[9-(4-Formylphenoxy)nonoxy]benzaldehyde
• CAS: 87367-64-4
• 化学式: C₂₃H₂₈O₄
• 分子量: 368.473
• InChiKey: WFSYRCWVQZEUTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  27
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2912299000

反应信息

• 作为反应物：
  描述：

  4,4'-[1,9-壬烷二基二(氧基)]二苯甲醛 在 哌啶 、 sodium hydroxide 、 溶剂黄146 作用下， 以 苯 为溶剂， 反应 42.0h， 生成 2-(4-{9-[4-(1,2-Dicarboxy-ethyl)-phenoxy]-nonyloxy}-phenyl)-succinic acid
  参考文献：
  名称：

  Relationship between chemical structure and anticonvulsive activity in 4,4′-(α, ω-alkylenedioxy)diphenylsuccinimides

  摘要：

  DOI：

  10.1007/bf00765771
• 作为产物：
  描述：

  对羟基苯甲醛 以77%的产率得到
  参考文献：
  名称：

  NESUNTS, N. S.;AVETISYAN, S. A.;DZHAGATSPANYAN, I. A.;AKOPYAN, N. E.;MNDZ+, XIM.-FARMATS. ZH., 1983, 17, N 7, 801-806

  摘要：

  DOI：

文献信息

• 27- to 39-Membered Pyridine Macrocycles
  作者：Ulrich Lüning、Ellen Mak、Melanie Zindler、Britta Hartkopf、Rainer Herges

  DOI：10.1002/ejoc.201000505

  日期：2010.9

  A set of 27- to 39-membered pyridine macrocycles 2 and 3 has been synthesized by Williamson ether synthesis or ring-closing metathesis. The pyridines are 2,6-disubstituted to allow endo interactions. In addition to the length, also the nature of the aliphatic chain was varied: saturated (2) and unsaturated (3).

  已经通过威廉姆森醚合成或闭环复分解合成了一组 27 至 39 元吡啶大环 2 和 3。吡啶是 2,6-二取代的以允许内相互作用。除了长度之外，脂肪链的性质也不同：饱和（2）和不饱和（3）。
• Mesomorphic Behavior of Symmetric Azomethine Dimers Containing Different Chromophore Groups
  作者：Elena Perju、Luminita Marin

  DOI：10.3390/molecules26082183

  日期：——

  A series of new azomethine dimers was synthesized by the condensation reaction of flexible bis-benzaldehydes with four aromatic amines containing phenyl, naphthyl, anthracene and pyrene groups. Their right structure was confirmed by FTIR and 1H-NMR spectroscopy and their thermal properties were investigated by thermogravimetric analysis, differential scanning calorimetry and polarized light optical microscopy. A view on their photophysical behavior was gained by UV-vis and photoluminescence spectroscopy. The dimers containing pyrene and anthracene presented liquid crystalline behavior, while the other dimers were crystalline compounds. Two dimers containing pyrene moieties formed mesomorphic glasses and had intense luminescence, promising properties for applications in building optoelectronic devices.

  一系列新的偶氮亚甲基二聚体通过柔性双苯甲醛与含有苯基、萘基、蒽基和芘基的四种芳香胺的缩合反应合成。它们的正确结构经过傅立叶红外光谱和1H-NMR光谱确认，它们的热性质通过热重分析、差示扫描量热法和偏光光学显微镜进行研究。通过紫外-可见光谱和光致发光光谱获得了它们的光物理行为。含有芘和蒽的二聚体呈现液晶行为，而其他二聚体是结晶化合物。含有芘基团的两个二聚体形成了介晶玻璃，并具有强烈的发光，这些性质有望应用于光电子器件的制造。
• Bisoxadiazolidine derivative
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US05643931A1

  公开（公告）日：1997-07-01

  A bisoxadiazolidine dione derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as an insulin sensitivity-increasing drug, and a pharmaceutical composition thereof. ##STR1## each represents a phenylene group L: (1) an oxygen, (2) a ##STR2## (3) a --S(O).sub.n --, (4) a --CO--, (5) a ##STR3## (6) an alkylene group or an alkenylene group which may respectively be interrupted with an oxygen atom and/or a sulfur atom.

  由以下一般式(I)表示的一种双噁唑烷二酮衍生物或其药学上可接受的盐，用作胰岛素敏感性增强药物，以及其药物组合物。##STR1##每个代表一个苯基L：(1) 氧，(2) ##STR2## (3) --S(O).sub.n --，(4) --CO--，(5) ##STR3## (6) 可分别用氧原子和/或硫原子中断的烷基或烯基基团。
• Symmetric and non-symmetric liquid crystal dimers with branched terminal alkyl chains: racemic and chiral
  作者：Andrew E. Blatch、Ian D. Fletcher、Geoffrey R. Luckhurst

  DOI：10.1039/a602980i

  日期：——

  Two new series of racemic dimeric liquid crystals containing terminal alkyl chains with methyl branches are presented; in one the dimers are symmetric and in the other they are non-symmetric. Comparisons are made with the structurally isomeric series with no methyl branches in their terminal alkyl chains. The stability and clearing temperatures of the liquid crystal phases are markedly reduced for the dimers with methyl branches, particularly for the symmetric dimers. Chiral analogues of both series were also examined. The liquid crystal behaviour of the non-symmetric dimers is of particular interest. Four homologues were studied with the number of methylene units in the spacer ranging from six to nine. An odd–even effect was observed for the chiral properties of these materials. Blue phase I behaviour was exhibited by the heptane and nonane homologues but not by the even membered hexane and octane members of the series.

  本文介绍了两个新的外消旋二聚液晶系列，其中一个系列中的二聚物是对称的，另一个系列中的二聚物是不对称的。并与末端烷基链中没有甲基分支的结构异构系列进行了比较。有甲基支链的二聚体，尤其是对称二聚体，液晶相的稳定性和清澈温度明显降低。我们还研究了这两个系列的手性类似物。非对称二聚体的液晶行为尤其引人关注。我们研究了四种同系物，其间隔中亚甲基单位的数量从六个到九个不等。观察到这些材料的手性具有奇偶效应。该系列中的庚烷和壬烷同系物表现出蓝色 I 相行为，而偶数成员的己烷和辛烷则没有。
• NOVEL BISOXADIAZOLIDINE DERIVATIVE
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0696585A1

  公开（公告）日：1996-02-14

  A bisoxadiazolidinedione derivative of general formula (I) useful as an insulin-sensitivity improver, a pharmaceutically acceptable salt thereof, and a medicinal composition thereof, wherein (a) and (b) may be the same or different from each other and each represent an optionally substituted phenylene group, and L represents: (1) an oxygen atom, (2) a group of formula (II) (R¹ being a hydrogen atom or a lower alkyl group), (3) a group of the formula: -S(O)n- (n being 0, 1 or 2), (4) a group of the formula: -CO-, (5) a group of formula (III) or (IV) (R² being a hydrogen atom or a lower alkyl group), or (6) an alkylene or alkenylene group which may be substituted and interrupted by an oxygen atom and/or a sulfur atom, and the like.

  一种用作胰岛素敏感性改善剂的通式(I)的双噁二唑烷二酮衍生物、其药学上可接受的盐及其药物组合物，其中(a)和(b)可以相同或互不相同，且各自代表任选取代的亚苯基，L代表：(1) 氧原子，(2) 式 (II) 的基团（R¹ 为氢原子或低级烷基），(3) 式中的基团：-S(O)n-（n 为 0、1 或 2），(4) 式中的一个基团：-CO-，(5)式(III)或(IV)的基团（R²为氢原子或低级烷基），或(6)可被氧原子和/或硫原子取代和间断的亚烷基或烯基等。