4,4'-[1,8-辛烷二基二(氧基)]二苯甲醛 | 77355-03-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4,4'-[1,8-辛烷二基二(氧基)]二苯甲醛
• 英文名称: 4,4'-(octane-1, 8-diylbis(oxy))dibenzaldehyde
• 英文别名: octamethylene-1,6-bis(4-oxybenzaldehyde)；octamethylene-1,8-bis(4-oxybenzaldehyde)；1,8-bis(4-formylphenoxy)octane；1,8-bis-(4'-formylphenoxy)-n-octane；1,8-bis(4'-formylphenoxy)-n-octane；4-[8-(4-Formylphenoxy)octoxy]benzaldehyde
• CAS: 77355-03-4
• 化学式: C₂₂H₂₆O₄
• 分子量: 354.446
• InChiKey: BLXNWXHHTVEXPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  26
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2912299000

反应信息

• 作为反应物：
  描述：

  4,4'-[1,8-辛烷二基二(氧基)]二苯甲醛 在 哌啶 、 sodium hydroxide 、 溶剂黄146 作用下， 以 苯 为溶剂， 反应 42.0h， 生成 2-[4-[8-[4-(1,2-dicarboxyethyl)phenoxy]octoxy]phenyl]butanedioic acid
  参考文献：
  名称：

  Relationship between chemical structure and anticonvulsive activity in 4,4′-(α, ω-alkylenedioxy)diphenylsuccinimides

  摘要：

  DOI：

  10.1007/bf00765771
• 作为产物：
  描述：

  对羟基苯甲醛 以76%的产率得到
  参考文献：
  名称：

  NESUNTS, N. S.;AVETISYAN, S. A.;DZHAGATSPANYAN, I. A.;AKOPYAN, N. E.;MNDZ+, XIM.-FARMATS. ZH., 1983, 17, N 7, 801-806

  摘要：

  DOI：

文献信息

• New bispyrazoline derivatives built around aliphatic chains: Synthesis, characterization and antimicrobial studies
  作者：MOHAMAD YUSUF、PAYAL JAIN

  DOI：10.1007/s12039-012-0355-9

  日期：2013.1

  Aspergillius janus, Aspergillus niger and Pencillium glabrum, respectively. The antimicrobial behaviour of the bispyrazolines 3a–3h is found to be dependent on the length of internal spacer unit. Synthesis and antimicrobial behaviour of the bispyrazolines built around the aliphatic chains have been described. The antimicrobial behaviour of these bisheterocyclic compounds is found to be dependent on the

  双吡唑啉3a - 3h围绕不同长度的烷基链构建，是由比沙可康烯与苯基肼的环化反应合成的。从苯乙酮与各种双醛1a - 1h的Claisen-Schmidt反应中获得了Bischalcones 2a - 2h。通过IR，1 H-NMR，13 C-NMR，质量（ESI）和元素分析来表征中间的双缩水锥和最终的双杂环化合物。还评估了合成化合物的抗细菌和抗真菌活性，对肺炎克氏杆菌，铜绿假单胞菌，大肠埃希菌，金黄色葡萄球菌，枯草芽孢杆菌和janjan曲霉，黑曲霉和延寿草。发现双吡唑啉3a – 3h的抗菌性能取决于内部间隔单元的长度。 已经描述了围绕脂族链构建的双吡唑啉的合成和抗菌性能。发现这些双杂环化合物的抗微生物行为取决于内部间隔单元的长度。
• Helical Self-Assemblies of Segmented Poly(phenylenevinylene)s and Their Hierarchical Donor–Acceptor Complexes
  作者：Mahima Goel、Karnati Narasimha、Manickam Jayakannan

  DOI：10.1021/ma5003112

  日期：2014.4.22

  π-conjugated polymer aggregates in methanol and tetrahydrofuran (THF) solvent combinations. Electron microscopic studies confirmed that these π-aggregates appeared as bundles of helical assemblies. An electron deficient perylenebisimide derivative was complexed with segmented polymers to produce stable and helical donor–acceptor hierarchical assemblies. The formation of D–A assemblies was confirmed

  我们通过溶剂诱导的自组织过程报告了分段聚（苯撑乙烯撑）的芳香族π堆栈驱动的螺旋自组装及其具有电子缺陷的分子的分层螺旋供体-受体组装。设计并合成了具有三环癸烷取代的低聚亚苯基亚乙烯基（OPV）π-核以及可变碳原子数为4,8和12的柔性亚甲基链的新型分段PPV。这些聚合物以高分子量得到，在普通有机溶剂中的溶解度非常好。发现该聚合物是无定形的，并且相对于聚合物主链的刚性增加，它们的玻璃化转变温度在100至170℃之间变化。柔性链段聚合物经过芳族π-堆栈相互作用，在甲醇和四氢呋喃（THF）溶剂组合中产生π-共轭聚合物聚集体。电子显微镜研究证实，这些π-聚集体以螺旋组件的束的形式出现。缺电子的per二酰亚胺衍生物与链状聚合物复合，生成稳定的螺旋形供体-受体分层组装体。D–A组件的形成已通过详细的光物理研究证实，例如吸光度，发射，时间分辨的荧光衰减和FRET机理。使用结构相同的刚性聚合物进行的对照实验
• Mesomorphic Behavior of Symmetric Azomethine Dimers Containing Different Chromophore Groups
  作者：Elena Perju、Luminita Marin

  DOI：10.3390/molecules26082183

  日期：——

  A series of new azomethine dimers was synthesized by the condensation reaction of flexible bis-benzaldehydes with four aromatic amines containing phenyl, naphthyl, anthracene and pyrene groups. Their right structure was confirmed by FTIR and 1H-NMR spectroscopy and their thermal properties were investigated by thermogravimetric analysis, differential scanning calorimetry and polarized light optical microscopy. A view on their photophysical behavior was gained by UV-vis and photoluminescence spectroscopy. The dimers containing pyrene and anthracene presented liquid crystalline behavior, while the other dimers were crystalline compounds. Two dimers containing pyrene moieties formed mesomorphic glasses and had intense luminescence, promising properties for applications in building optoelectronic devices.

  一系列新的偶氮亚甲基二聚体通过柔性双苯甲醛与含有苯基、萘基、蒽基和芘基的四种芳香胺的缩合反应合成。它们的正确结构经过傅立叶红外光谱和1H-NMR光谱确认，它们的热性质通过热重分析、差示扫描量热法和偏光光学显微镜进行研究。通过紫外-可见光谱和光致发光光谱获得了它们的光物理行为。含有芘和蒽的二聚体呈现液晶行为，而其他二聚体是结晶化合物。含有芘基团的两个二聚体形成了介晶玻璃，并具有强烈的发光，这些性质有望应用于光电子器件的制造。
• The Syntheses of 4,4′-(1,n-Dioxaalkane)-bisbenzaldehydes and 4,4′-(1,n-Dioxaalkane)-bis(α-methoxy Phenylacetic Acids)
  作者：Jianjun Jiang、Edward L. Compere

  DOI：10.1080/00397919808003072

  日期：1998.3.1

  acetic acids) were conducted using a base-catalyzed reaction. The reactants were potassium hydroxide (or lithium hydroxide/lithium chloride), bromoform, methanol and 4,4′-(1,n-dioxaalkane)-bisbenzaldehydes. The aldehyde starting materials were prepared using the Williamson ether synthesis, by condensing p-hydroxybenzaldehyde and 1,n-dibromoalkanes with lithium hydride in ethanol. The effect of varying

  摘要 4,4'-(1,n-二恶烷)-双(α-甲氧基苯乙酸)的合成采用碱催化反应进行。反应物为氢氧化钾（或氢氧化锂/氯化锂）、溴仿、甲醇和 4,4'-（1,n-二恶烷）-双苯甲醛。醛原料使用威廉姆森醚合成法制备，通过对羟基苯甲醛和 1,n-二溴烷烃与氢化锂在乙醇中的缩合。改变二氧杂烷烃桥单元中烃长度的影响是其酸式盐形成的一个重要考虑因素（桥中 CH2 单元的数量从 2 到 8 个不等）。†当前地址：D-54Z, R-13, Abbott Laboratories, 1401 Sheridan Road, North Chicago, IL 60064-4000。
• Symmetric and non-symmetric liquid crystal dimers with branched terminal alkyl chains: racemic and chiral
  作者：Andrew E. Blatch、Ian D. Fletcher、Geoffrey R. Luckhurst

  DOI：10.1039/a602980i

  日期：——

  Two new series of racemic dimeric liquid crystals containing terminal alkyl chains with methyl branches are presented; in one the dimers are symmetric and in the other they are non-symmetric. Comparisons are made with the structurally isomeric series with no methyl branches in their terminal alkyl chains. The stability and clearing temperatures of the liquid crystal phases are markedly reduced for the dimers with methyl branches, particularly for the symmetric dimers. Chiral analogues of both series were also examined. The liquid crystal behaviour of the non-symmetric dimers is of particular interest. Four homologues were studied with the number of methylene units in the spacer ranging from six to nine. An odd–even effect was observed for the chiral properties of these materials. Blue phase I behaviour was exhibited by the heptane and nonane homologues but not by the even membered hexane and octane members of the series.

  本文介绍了两个新的外消旋二聚液晶系列，其中一个系列中的二聚物是对称的，另一个系列中的二聚物是不对称的。并与末端烷基链中没有甲基分支的结构异构系列进行了比较。有甲基支链的二聚体，尤其是对称二聚体，液晶相的稳定性和清澈温度明显降低。我们还研究了这两个系列的手性类似物。非对称二聚体的液晶行为尤其引人关注。我们研究了四种同系物，其间隔中亚甲基单位的数量从六个到九个不等。观察到这些材料的手性具有奇偶效应。该系列中的庚烷和壬烷同系物表现出蓝色 I 相行为，而偶数成员的己烷和辛烷则没有。