5-sec-butylindole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-sec-butylindole
• 英文别名: 5-(sec-butyl)-1H-indole；5-Sec-butyl-1H-indole；5-butan-2-yl-1H-indole
• 化学式: C₁₂H₁₅N
• 分子量: 173.258
• InChiKey: YXFJPPJKFXDSFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  5-sec-butylindole 、 5-Sec-butyl-1-trifluoroacetylindole 生成 5-(1-甲基乙基)-1H-吲哚
  参考文献：
  名称：

  5-alkyl indole compounds

  摘要：

  本文描述了一些选择性作用于5-HT.sub.1D-类似受体的化合物，其通式如下：## STR1 ## 其中：R.sup.1是线性或支链低碳基；R.sup.2是从公式II、III、IV和V的一组中选择的：## STR2 ## R.sup.3从H和低碳基中选择；R.sup.4从H和低碳基中选择；R.sup.5和R.sup.6中的一个是H，另一个独立地选择自H，低碳氧基，低碳基和羟基；n为1-3；或其盐，溶剂合物或水合物。同时还描述了这些化合物作为药物治疗5-HT.sub.1D-类似受体刺激相关症状的用途，如偏头痛。

  公开号：

  US05998462A1
• 作为产物：
  描述：

  5-碘吲哚 、 2-碘丁烷 在 锌 、 α,α,α-三联吡啶 、 nickel dichloride 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以75%的产率得到5-sec-butylindole
  参考文献：
  名称：

  Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides and Aryl Iodides

  摘要：

  A general Ni-catalyzed process for the cross-coupling of secondary alkylzinc halides and aryl/heteroaryl iodides has been developed. This is the first process to overcome the isomerization and beta-hydride elimination problems that are associated with the use of secondary nucleophiles, and that have limited the analogous Pd-catalyzed systems. The impact of salt additives was also investigated. It was found that the presence of LiBF4 dramatically improves both isomeric retention and yield for challenging substrates.

  DOI：

  10.1021/ol200098d

文献信息

• Nickel-Catalyzed Reductive Coupling of Aryl Halides with Secondary Alkyl Bromides and Allylic Acetate
  作者：Shulin Wang、Qun Qian、Hegui Gong

  DOI：10.1021/ol3013342

  日期：2012.7.6

  A room-temperature Ni-catalyzed reductive method for the coupling of aryl bromides with secondary alkyl bromides has been developed, providing C(sp2)–C(sp3) products in good to excellent yields. Slight modification of this protocol allows efficient coupling of activated aryl chlorides with cyclohexyl bromide and aryl bromides with allylic acetate.

  已经开发了一种室温镍催化的还原方法，用于将芳基溴化物与仲烷基溴化物偶合，从而以良好的收率提供了良好的C（sp 2）–C（sp 3）产品。对该协议进行轻微修改，即可使活化的芳基氯化物与环己基溴化物有效偶联，而芳基溴化物与乙酸烯丙酯有效偶联。
• Ruthenium-catalyzed heteroannulation of anilines with alkanolammonium chlorides leading to indoles
  作者：Chan Sik Cho、Jin Hwang Kim、Tae-Jeong Kim、Sang Chul Shim

  DOI：10.1016/s0040-4020(01)00202-2

  日期：2001.4

  Anilines react with alkanolammonium chlorides in an aqueous medium (H2O–dioxane) at 180°C in the presence of a catalytic amount of a ruthenium catalyst together with SnCl2·2H2O to afford the corresponding indoles in moderate to good yields. Especially, when triisopropanolammonium chloride is employed to react with anilines, 2-methylindoles are formed regioselectively. The presence of SnCl2·2H2O is

  在催化量的钌催化剂和SnCl 2 ·2H 2 O的存在下，苯胺在水性介质（H 2 O-二恶烷）中在180°C下与链烷醇氯化铵反应，以中等至良好的收率得到相应的吲哚。特别是，当使用氯化三异丙基丙铵与苯胺反应时，区域选择性地形成2-甲基吲哚。的SnCl存在2 ·2H 2 O为必需的有效形成吲哚。针对该催化过程，提出了一种涉及链烷醇基团从链烷醇胺转移至苯胺，苯胺被苯胺链烷醇进行N-烷基化以及1,2-二苯胺基烷烃的杂环化反应的反应途径。
• Ruthenium-catalyzed synthesis of indoles from anilines and trialkanolammonium chlorides in an aqueous medium
  作者：Chan Sik Cho、Jin Hwang Kim、Sang Chul Shim

  DOI：10.1016/s0040-4039(00)00035-6

  日期：2000.3

  Anilines react with trialkanolammonium chlorides in an aqueous medium (H2O–dioxane) at 180°C in the presence of a catalytic amount of ruthenium(III) chloride hydrate and triphenylphosphine together with tin(II) chloride dihydrate to afford the corresponding indoles in good yields.

  在催化量的氯化钌（III）水合物和三苯基膦与氯化锡（II）二水合存在下，苯胺在水性介质（H 2 O-二恶烷）中于180°C下与三氯氯化铵反应，得到相应的吲哚化合物。良品率高。
• Method for producing trimer of indole derivative, and trimer of indole derivative and laminated structure thereof
  申请人：——

  公开号：US20040019097A1

  公开（公告）日：2004-01-29

  The present invention provides an industrial method that allows to produce an indole derivative trimer with high purity in mass, as well as novel indole derivative trimers obtainable by the method, having high conductivity, high oxidation—reduction potential, high oxidation—reduction capacity, and the excellent cycle characteristics. The present invention relates to a method of producing an indole derivative trimer comprising the step of oxidizing an indole derivative in a reaction solution containing an organic solvent and to the novel trimers produced by the method.

  本发明提供了一种工业方法，可以在反应溶液中氧化含有有机溶剂的吲哚衍生物，从而制备高纯度的吲哚衍生物三聚体，并获得具有高电导率、高氧化还原电位、高氧化还原容量和优异循环特性的新型吲哚衍生物三聚体。本发明涉及一种制备吲哚衍生物三聚体的方法，包括氧化含有有机溶剂的吲哚衍生物的步骤，以及通过该方法制备的新型三聚体。
• Composition containing carbon nanotubes having coating thereof and process for producing them
  申请人：Saitoh Takashi

  公开号：US20060052509A1

  公开（公告）日：2006-03-09

  The object of the present invention is to provide a carbon nanotube composition that does not impair the characteristics of the carbon nanotubes itself, allows the carbon nanotubes to be dispersed or solubilized in a solvent, does not cause separation or aggregation of the carbon nanotubes even during long-term storage, has superior electrical conductivity, film formability and moldability, can be easily coated or covered onto a base material, and the resulting coated film has superior moisture resistance, weather resistance and hardness; a composite having a coated film composed thereof; and, their production methods. In order to achieve this object, the present invention provides a carbon nanotube composition that contains a conducting polymer (a) or heterocyclic compound trimer (i), a solvent (b) and carbon nanotubes (c), and may additionally contain a high molecular weight compound (d), a basic compound (e), a surfactant (f), a silane coupling agent (g) and colloidal silica (h) as necessary; a composite having a coated film composed of the composition; and, their production methods.

  本发明的目的是提供一种碳纳米管组合物，不会影响碳纳米管本身的特性，使碳纳米管可以分散或溶解在溶剂中，在长期储存期间不会导致碳纳米管分离或聚集，具有优异的电导性、成膜性和成型性，可以轻松地涂覆或覆盖在基材上，所得到的涂层膜具有优异的防潮性、耐候性和硬度；一种由涂层膜组成的复合材料；以及它们的生产方法。为了实现这一目的，本发明提供了一种碳纳米管组合物，其中包含导电聚合物(a)或杂环化合物三聚体(i)、溶剂(b)和碳纳米管(c)，并可根据需要另外包含高分子量化合物(d)、碱性化合物(e)、表面活性剂(f)、硅烷偶联剂(g)和胶体二氧化硅(h)；一种由该组合物组成的涂层膜复合材料；以及它们的生产方法。