2-hydroxy-4-methoxy-3-methylbenzoic acid | 116371-82-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-4-methoxy-3-methylbenzoic acid
• 英文别名: 2-hydroxy-4-methoxy-3-methyl-benzoic acid；2-Hydroxy-4-methoxy-3-methyl-benzoesaeure；2-Oxy-4-methoxy-3-methyl-benzoesaeure
• CAS: 116371-82-5
• 化学式: C₉H₁₀O₄
• 分子量: 182.176
• InChiKey: LZHDGQOTJRJHBX-UHFFFAOYSA-N

物化性质

• 熔点：
  215-216 °C
• 沸点：
  323.8±42.0 °C(Predicted)
• 密度：
  1.295±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-hydroxy-4-methoxy-3-methylbenzoic acid 在 氢氧化钾 、 氢碘酸 作用下， 生成 2,6-bis-benzoyloxy-toluene
  参考文献：
  名称：

  Herzig; Wenzel; Haiser, Monatshefte fur Chemie, 1903, vol. 24, p. 908

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基2,4-二羟基-3-苯甲酸乙酯 在 甲醇 、 alkaline solution 、 sodium methylate 作用下， 生成 2-hydroxy-4-methoxy-3-methylbenzoic acid
  参考文献：
  名称：

  340. γ 3'-取代的间苯二酚核。第一部分：γ-间苯二醛的合成

  摘要：

  DOI：

  10.1039/jr9380001828

文献信息

• BENZOFURANYL- AND BENZOTHIENYL- PIPERAZINYL QUINOLINES AND METHODS OF THEIR USE
  申请人：Venkatesan Aranapakam Mudumbai

  公开号：US20090054454A1

  公开（公告）日：2009-02-26

  Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.

  本专利揭示了苯并呋喃基和苯并噻吩基哌嗪喹啉衍生物以及含有这些化合物的组合物。还揭示了使用苯并呋喃基和苯并噻吩基哌嗪喹啉衍生物以及含有这种组合物在治疗和/或预防与5-羟色胺相关的疾病，如抑郁症和焦虑症的方法。此外，还揭示了制备苯并呋喃基和苯并噻吩基哌嗪喹啉衍生物的方法。
• Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
  申请人：Venkatesan Mudumbai Aranapakam

  公开号：US20050004162A1

  公开（公告）日：2005-01-06

  3-Piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed. Methods of using the derivatives and compositions containing the derivatives in the prevention and/or treatment of serotonin disorders, such as depression and anxiety, are also disclosed. Additionally, processes for the preparation of 3-piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed.

  3-哌啶基-1H-吲哚和3-(1,2,3,6-四氢吡啶-4-基)-1H-吲哚衍生物已被披露。还披露了使用这些衍生物以及含有这些衍生物的组合物在预防和/或治疗血清素紊乱，如抑郁症和焦虑症方面的方法。此外，还披露了制备3-哌啶基-1H-吲哚和3-(1,2,3,6-四氢吡啶-4-基)-1H-吲哚衍生物的方法。
• Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
  申请人：Venkatesan Mudumbai Aranapakam

  公开号：US20050059673A1

  公开（公告）日：2005-03-17

  Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.

  本发明涉及苯并呋喃基-和苯并噻吩基-哌嗪基喹啉衍生物及含有该类化合物的组合物。本发明还涉及使用苯并呋喃基-和苯并噻吩基-哌嗪基喹啉衍生物及含有该类组合物治疗和/或预防与血清素相关的疾病，例如抑郁和焦虑。此外，还公开了制备苯并呋喃基-和苯并噻吩基-哌嗪基喹啉衍生物的方法。
• PIPERIDINYL INDOLE AND TETROHYDROPYRIDINYL INDOLE DERIVATIVES AND METHODS OF THEIR USE
  申请人：Venkatesan Mudumbai Aranapakam

  公开号：US20070225319A1

  公开（公告）日：2007-09-27

  3-Piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed. Methods of using the derivatives and compositions containing the derivatives in the prevention and/or treatment of serotonin disorders, such as depression and anxiety, are also disclosed. Additionally, processes for the preparation of 3-piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed.

  本发明揭示了3-哌啶基-1H-吲哚和3-(1,2,3,6-四氢-吡啶-4-基)-1H-吲哚衍生物。本发明还揭示了使用这些衍生物和含有这些衍生物的组合物在预防和/或治疗血清素紊乱，如抑郁症和焦虑症方面的方法。此外，本发明还揭示了制备3-哌啶基-1H-吲哚和3-(1,2,3,6-四氢-吡啶-4-基)-1H-吲哚衍生物的过程。
• Spaeth; Pesta, Chemische Berichte, 1933, vol. 66, p. 754,759
  作者：Spaeth、Pesta

  DOI：——

  日期：——