1-[(1-ethylpropyl)oxy]-3-(methyloxy)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[(1-ethylpropyl)oxy]-3-(methyloxy)benzene
• 英文别名: 1-methoxy-3-(pentan-3-yloxy)benzene；1-Methoxy-3-pentan-3-yloxybenzene
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: YEOQACHGNSTIMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,3-二氟苯 在 N,N-二甲基丙烯基脲 、 potassium tert-butylate 作用下， 以 乙二醇二甲醚 、 甲苯 为溶剂， 反应 47.0h， 生成 1-[(1-ethylpropyl)oxy]-3-(methyloxy)benzene
  参考文献：
  名称：

  Novel Synthesis of Desymmetrized Resorcinol Derivatives:  Aryl Fluoride Displacement on Deactivated Substrates

  摘要：

  A short, high-yielding synthesis of differentially substituted resorcinol derivatives has been developed that utilizes 1,3difluorobenzene as the starting material and employs sequential nucleophilic aromatic substitution (SNAr) reactions to generate desymmetrized products. The scope and limitations of the second SNAr reaction on the deactivated 1-alkoxy-3-fluorobenzene intermediates have been investigated. This methodology has also been employed in the synthesis of desymmetrized catechol derivatives from 1,2difluorobenzene.

  DOI：

  10.1021/jo0523868

文献信息

• Straightforward Synthesis of Ethers: Metal-Free Reductive Coupling of Tosylhydrazones with Alcohols or Phenols
  作者：José Barluenga、María Tomás-Gamasa、Fernando Aznar、Carlos Valdés

  DOI：10.1002/anie.201001704

  日期：——

  Ethers made easy: Heating a solution containing a tosylhydrazone and either a phenol or an alcohol in the presence of K2CO3 leads to the corresponding ethers (see scheme; MW=microwave, Ts=tosyl). The reaction is fairly general for the preparation of aryl alkyl and alkyl alkyl ethers, and represents a new method for the reductive etherification of carbonyl compounds.

  醚变得容易：在K 2 CO 3存在下加热含有甲苯磺酰s和苯酚或醇的溶液会生成相应的醚（参见方案； MW =微波，Ts =甲苯磺酰基）。该反应对于制备芳基烷基和烷基烷基醚是相当普遍的，并且代表了一种用于羰基化合物的还原醚化的新方法。
• US7541466B2
  申请人：——

  公开号：US7541466B2

  公开（公告）日：2009-06-02