4-Methyloxy-5-hexen-1-ol mesylate | 1027246-76-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 4-Methyloxy-5-hexen-1-ol mesylate
• 英文别名: 4-Methoxyhex-5-enyl methanesulfonate
• CAS: 1027246-76-9
• 化学式: C₈H₁₆O₄S
• 分子量: 208.279
• InChiKey: PPCNBVDAOGYTLA-UHFFFAOYSA-N

物化性质

• 沸点：
  322.6±35.0 °C(Predicted)
• 密度：
  1.097±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-Methyloxy-5-hexen-1-ol mesylate 在 偶氮二异丁腈 、 三正丁基氢锡 、 sodium iodide 作用下， 以 丙酮 、 苯 为溶剂， 反应 11.75h， 生成 环己基甲醚
  参考文献：
  名称：

  Cyclization of (4-Methoxy-5-hexenyl)lithium

  摘要：

  The cyclization of (4-methoxy-5-hexenyl)lithium (1), which was prepared by lithium-iodine exchange between 3-methoxy-6-iodo-1-hexene (2) and 1.75 molar equiv of t-BuLi in diethyl ether-n-pentane solution at -78 degrees C, has been investigated in a variety of solvent systems. The isomeric composition of the cis- and trans-1-methoxy-2-methylcyclopentane produced upon cyclization of 1 followed by quench with MeOH has been found to be dramatically dependent on the solvent system in which the isomerization is conducted.

  DOI：

  10.1021/jo00101a010
• 作为产物：
  描述：

  6-<(Tetrahydropyran-2-yl)oxy>-1-hexen-3-ol 在 盐酸 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 1.5h， 生成 4-Methyloxy-5-hexen-1-ol mesylate
  参考文献：
  名称：

  Cyclization of (4-Methoxy-5-hexenyl)lithium

  摘要：

  The cyclization of (4-methoxy-5-hexenyl)lithium (1), which was prepared by lithium-iodine exchange between 3-methoxy-6-iodo-1-hexene (2) and 1.75 molar equiv of t-BuLi in diethyl ether-n-pentane solution at -78 degrees C, has been investigated in a variety of solvent systems. The isomeric composition of the cis- and trans-1-methoxy-2-methylcyclopentane produced upon cyclization of 1 followed by quench with MeOH has been found to be dramatically dependent on the solvent system in which the isomerization is conducted.

  DOI：

  10.1021/jo00101a010

文献信息

• Cyclization of (4-Methoxy-5-hexenyl)lithium
  作者：William F. Bailey、Xing-Long Jiang

  DOI：10.1021/jo00101a010

  日期：1994.11

  The cyclization of (4-methoxy-5-hexenyl)lithium (1), which was prepared by lithium-iodine exchange between 3-methoxy-6-iodo-1-hexene (2) and 1.75 molar equiv of t-BuLi in diethyl ether-n-pentane solution at -78 degrees C, has been investigated in a variety of solvent systems. The isomeric composition of the cis- and trans-1-methoxy-2-methylcyclopentane produced upon cyclization of 1 followed by quench with MeOH has been found to be dramatically dependent on the solvent system in which the isomerization is conducted.