(9ci)-2,3-二氢-5-(1-甲基乙氧基)-1H-茚-1-酮 | 760995-38-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: (9ci)-2,3-二氢-5-(1-甲基乙氧基)-1H-茚-1-酮
• 英文名称: 5-isopropoxy-2,3-dihydro-1H-inden-1-one
• 英文别名: 5-isopropoxyindan-1-one；5-propan-2-yloxy-2,3-dihydroinden-1-one
• CAS: 760995-38-8
• 化学式: C₁₂H₁₄O₂
• 分子量: 190.242
• InChiKey: NLUPNAKVXJFJDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (9ci)-2,3-二氢-5-(1-甲基乙氧基)-1H-茚-1-酮 在 盐酸 、 亚硝酸异戊酯 、 聚合甲醛 作用下， 以 甲醇 、 水 为溶剂， 生成 5-isopropoxy-1H-indene-1,2(3H)-dione
  参考文献：
  名称：

  [EN] TRANSCRIPTION FACTOR BRN2 INHIBITORY COMPOUNDS FOR USE AS THERAPEUTICS
  [FR] COMPOSÉS INHIBITEURS DU FACTEUR DE TRANSCRIPTION BRN2 DESTINÉS À ÊTRE UTILISÉS EN TANT QU'AGENTS THÉRAPEUTIQUES

  摘要：

  This invention provides compound having a structure of Formula (I)or (II): (I, II ) and uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provide. Furthermore, the compounds described herein may be used for the treatment of BRN2 expressing cancers. The cancer selected from prostate cancer; lung cancer; bladder cancer; sarcoma; glioma; and melanoma.

  公开号：

  WO2023023853A1
• 作为产物：
  描述：

  5-羟基-1-茚酮 、 2-溴丙烷 在 caesium carbonate 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 以100%的产率得到(9ci)-2,3-二氢-5-(1-甲基乙氧基)-1H-茚-1-酮
  参考文献：
  名称：

  [EN] FUSED TRI AND TETRA-CYCLIC PYRAZOLE KINASE INHIBITORS
  [FR] INHIBITEURS DE PYRAZOLE KINASE FUSIONNEE TRICYCLIQUE ET TETRACYCLIQUE

  摘要：

  具有化学式(I) (I)的化合物对抑制蛋白激酶很有用。还公开了制备这些化合物的方法、含有这些化合物的组合物，以及使用这些化合物进行治疗的方法。

  公开号：

  WO2004080973A1

文献信息

• Fused tri and tetra-cyclic pyrazole kinase inhibitors
  申请人：——

  公开号：US20040259904A1

  公开（公告）日：2004-12-23

  Compounds having the formula (I) 1 are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  化合物具有公式（I）1，对于抑制蛋白激酶具有用途。还公开了制备该化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
• Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury
  作者：Siyang Xiao、Wenxin Zhang、Hongjin Chen、Bo Fang、Yinda Qiu、Xianxin Chen、Lingfeng Chen、Shen Shu、Yali Zhang、Yunjie Zhao、Zhiguo Liu、Guang Liang

  DOI：10.2147/dddt.s160314

  日期：——

  Purpose: The purpose of this study was to design and synthesize novel 2-benzylidene-1-indanone derivatives for treatment of acute lung injury.Methods: A series of 39 novel 2-benzylidene-indanone structural derivatives were synthesized and evaluated for anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated murine primary macrophages.Results: Most of the obtained compounds effectively inhibited the LPS-induced expression of IL-6 and TNF-alpha. The most active compound, 8f, was found to significantly reduce LPS-induced pulmonary inflammation, as reflected by reductions in the concentration of total protein, inflammatory cell count, as well as the lung wet/dry ratio in bronchoalveolar lavage (BAL) fluid. Furthermore, 8f effectively inhibited mRNA expression of several inflammatory cytokines after LPS challenge in vitro and in vivo. Administration of 8f also blocked LPS-induced activation of the proinflammatory NF-kappa B/MAPK signaling pathway.Conclusion: The simple synthetic preparation and biological properties of these derivatives make these 2-benzylidene-indanone scaffolds promising new entities for the development of anti-inflammatory therapeutics for the treatment of acute lung injury.
• US7320986B2
  申请人：——

  公开号：US7320986B2

  公开（公告）日：2008-01-22