1,3-diphenyl-4,5-dihydro-1H-benzo[g]indazole | 78604-93-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,3-diphenyl-4,5-dihydro-1H-benzo[g]indazole
• 英文别名: 1,3-Diphenyl-4,5-dihydrobenzo[g]indazole
• CAS: 78604-93-0
• 化学式: C₂₃H₁₈N₂
• 分子量: 322.409
• InChiKey: QYIYVTJTFLXBBR-UHFFFAOYSA-N

物化性质

• 熔点：
  172 °C
• 沸点：
  528.6±29.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-(3,4-dihydro-1-naphthalenyl)morpholine 生成 1,3-diphenyl-4,5-dihydro-1H-benzo[g]indazole
  参考文献：
  名称：

  Regioselectivity and specificity in cycloaddition of diphenylnitrilimine

  摘要：

  DOI：

  10.1016/s0040-4039(01)90278-3

文献信息

• AlCl3-promoted reaction of cycloalkanones with hydrazones: a convenient direct synthesis of 4,5,6,7-tetrahydro-1H-indazoles and their analogues
  作者：Rima Laroum、Fabienne Berrée、Thierry Roisnel、Vincent Dorcet、Bertrand Carboni、Abdelmadjid Debache

  DOI：10.1016/j.tetlet.2019.150988

  日期：2019.8

  The AlCl3-promoted reactions of cycloalkanones with hydrazones are described. This approach represents a mild and operationally simple method to access 2,3-diaryl-4,5,6,7-tetrahydro-1H-indazoles and their analogues in good to moderate yields.

  描述了环烷酮与的AlCl 3促进的反应。这种方法代表了一种温和且操作简单的方法，可以以良好至中等的产率获得2,3-二芳基-4,5,6,7-四氢-1 H-吲唑及其类似物。
• [3 + 2] Cycloaddition of Nitrile Imines with Enamides: An Approach to Functionalized Pyrazolines and Pyrazoles
  作者：Liang Tu、Limei Gao、Xiaomeng Wang、Ruijie Shi、Rupei Ma、Junfei Li、Xiaoshuang Lan、Yongsheng Zheng、Jikai Liu

  DOI：10.1021/acs.joc.0c02244

  日期：2021.1.1

  with enamides has been established. A wide range of functionalized pyrazoline derivatives (53 examples) were obtained in moderate to good yields (up to 96%) under very mild conditions. This protocol features broad substrate scope, good functional group tolerance, and operational simplicity. Practical transformation of the products into useful pyrazoles via a one-pot process and the scalability of this

  已经建立了一种有效的[3 + 2]与酰胺共生的腈亚胺环加成反应。在非常温和的条件下，以中等至良好的收率（高达96％）获得了多种官能化的吡唑啉衍生物（53个实例）。该协议具有广泛的底物范围，良好的官能团耐受性和操作简便性。通过一锅法将产品实际转化为有用的吡唑，并且该协议的可扩展性突出了此合成方法的实用性。
• Tshiamala, Kabula; Kitane, Said; Vebrel, Joel, Bulletin des Societes Chimiques Belges, 1986, vol. 95, # 12, p. 1083 - 1098
  作者：Tshiamala, Kabula、Kitane, Said、Vebrel, Joel、Laude, Bernard

  DOI：——

  日期：——
• Corrigendum to “AlCl3-promoted reaction of cycloalkanones with hydrazones: A convenient direct synthesis of 4,5,6,7-tetrahydro-1H-indazoles and their analogues” [Tetrahedron Lett. 60 (2019) 150988]
  作者：Rima Laroum、Fabienne Berrée、Thierry Roisnel、Vincent Dorcet、Bertrand Carboni、Abdelmadjid Debache

  DOI：10.1016/j.tetlet.2019.151107

  日期：2019.10
• The Chemistry of Derivatives of 2-Benzaltetralone. IV.¹ The Synthesis, Spectra and Ring Cleavage Reactions of Some Spiroepoxyketones
  作者：Norman H. Cromwell、Ronald E. Bambury、Raymond P. Barkley

  DOI：10.1021/ja01525a045

  日期：1959.8