N-(5-(diethylamino)pentan-2-yl)-3-(3,4-dihydroquinolin-1(2H)-yl)propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(5-(diethylamino)pentan-2-yl)-3-(3,4-dihydroquinolin-1(2H)-yl)propanamide
• 英文别名: N-[5-(diethylamino)pentan-2-yl]-3-(3,4-dihydro-2H-quinolin-1-yl)propanamide
• 化学式: C₂₁H₃₅N₃O
• 分子量: 345.528
• InChiKey: FLMNNMQYPWCSHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(5-(diethylamino)pentan-2-yl)-3-(3,4-dihydroquinolin-1(2H)-yl)propanamide 在 哌啶 、 溶剂黄146 、 三氯氧磷 作用下， 反应 40.75h， 生成 N-[5-(diethylamino)pentan-2-yl]-3-[6-[2-[1-[3-[(2-hydroxy-3-naphthalen-1-yloxypropyl)amino]propyl]quinolin-1-ium-4-yl]ethenyl]-3,4-dihydro-2H-quinolin-1-yl]propanamide;bromide
  参考文献：
  名称：

  Autophagy and phospholipidosis pathway assays

  摘要：

  提供的是用于检测和监测自噬和磷脂沉积症的检测方法，包括溶酶体贮积病的进展。可以监测用于溶酶体贮积病的药物和治疗方法在溶酶体贮积病条件下的有效性。还可以筛选药物候选物和疑似毒性剂对细胞、组织和器官的毒性。还提供了区分磷脂沉积症激活剂和自噬途径干扰剂的方法。

  公开号：

  US09250249B2
• 作为产物：
  描述：

  1,2,3,4-四氢喹啉 在 O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 溶剂黄146 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 19.5h， 生成 N-(5-(diethylamino)pentan-2-yl)-3-(3,4-dihydroquinolin-1(2H)-yl)propanamide
  参考文献：
  名称：

  Autophagy and phospholipidosis pathway assays

  摘要：

  提供的是用于检测和监测自噬和磷脂沉积症的检测方法，包括溶酶体贮积病的进展。可以监测用于溶酶体贮积病的药物和治疗方法在溶酶体贮积病条件下的有效性。还可以筛选药物候选物和疑似毒性剂对细胞、组织和器官的毒性。还提供了区分磷脂沉积症激活剂和自噬途径干扰剂的方法。

  公开号：

  US09250249B2

文献信息

• Novel fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest
  申请人：Pande Praveen

  公开号：US20100068752A1

  公开（公告）日：2010-03-18

  The present invention provides dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes provided in this invention can comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been substituted with specific groups to provide beneficial properties.

  本发明提供染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质、核酸和细胞器。提供可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号产生。本发明提供的染料可以包括可用于将染料附着到将结合到所需目标分子的探针上的反应性基团。本发明的新型染料已经用特定的基团取代，以提供有益的特性。
• Fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest
  申请人：Pande Praveen

  公开号：US08362250B2

  公开（公告）日：2013-01-29

  The present invention provides dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes provided in this invention can comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been substituted with specific groups to provide beneficial properties.

  本发明提供了染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质、核酸和细胞器。提供了可以在溶液中自由使用的染料，其中染料与目标分子的结合提供信号产生。本发明提供的染料可以包含可用于将染料附着到将结合到所需目标分子的探针上的反应性基团。本发明的新型染料已经被替换为特定的基团，以提供有益的性质。
• Fluorescent dyes
  申请人：Enzo Biochem, Inc.

  公开号：US08476443B2

  公开（公告）日：2013-07-02

  The present invention provides dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes provided in this invention can comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been substituted with specific groups to provide beneficial properties.

  本发明提供染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质、核酸和细胞器。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号产生。本发明提供的染料可以包含反应性基团，可用于将染料附着到将结合到所需目标分子的探针上。本发明的新型染料已被替代为具有有益特性的特定基团。
• FLUORESCENT DYES
  申请人：Enzo Biochem, Inc.

  公开号：US20130115651A1

  公开（公告）日：2013-05-09

  The present invention provides dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes provided in this invention can comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been substituted with specific groups to provide beneficial properties.

  本发明提供染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质、核酸和细胞器。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号产生。本发明提供的染料可以包含反应性基团，可用于将染料附着到将结合到所需目标分子的探针上。本发明的新型染料已经用特定的基团进行了取代，以提供有益的性质。
• AUTOPHAGY AND PHOSPHOLIPIDOSIS PATHWAY ASSAYS
  申请人：Enzo Life Sciences, Inc.

  公开号：EP2993477A1

  公开（公告）日：2016-03-09

  Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.

  所提供的检测方法可用于检测和监测自噬和磷脂变性，包括溶酶体贮积疾病的进展。可以监测溶酶体贮积疾病的药物和治疗方法在溶酶体贮积疾病条件下的有效性。还可以筛选候选药物和疑似毒剂对细胞、组织和器官的毒性。此外，还提供了区分磷脂酶激活剂和自噬途径扰乱剂的方法。