4-((6-chloro-[1,2,4]triazolopyridazin-3-yl)methoxy)-7-methoxyquinoline | 1002308-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-((6-chloro-[1,2,4]triazolopyridazin-3-yl)methoxy)-7-methoxyquinoline
• 英文别名: 4-((6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)-7-methoxyquinoline；4-[(6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]-7-methoxyquinoline
• CAS: 1002308-57-7
• 化学式: C₁₆H₁₂ClN₅O₂
• 分子量: 341.757
• InChiKey: ZKPHODPMIWSKQC-UHFFFAOYSA-N

物化性质

• 密度：
  1.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  74.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-((6-chloro-[1,2,4]triazolopyridazin-3-yl)methoxy)-7-methoxyquinoline 生成 7-甲氧基-4-[(6-苯基-1,2,4-三唑并[4,3-B]哒嗪-3-基)甲氧基]喹啉
  参考文献：
  名称：

  J. Med. Chem. 2008, 51, 2879-2882

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(6-chloropyridazin-3-yl)-2-(7-methoxyquinolin-4-yl)oxyacetohydrazide 以78的产率得到4-((6-chloro-[1,2,4]triazolopyridazin-3-yl)methoxy)-7-methoxyquinoline
  参考文献：
  名称：

  J. Med. Chem. 2008, 51, 2879-2882

  摘要：

  DOI：

文献信息

• Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase
  作者：Brian K. Albrecht、Jean-Christophe Harmange、David Bauer、Loren Berry、Christiane Bode、Alessandro A. Boezio、April Chen、Deborah Choquette、Isabelle Dussault、Cary Fridrich、Satoko Hirai、Doug Hoffman、Jay F. Larrow、Paula Kaplan-Lefko、Jasmine Lin、Julia Lohman、Alexander M. Long、Jodi Moriguchi、Anne O’Connor、Michele H. Potashman、Monica Reese、Karen Rex、Aaron Siegmund、Kavita Shah、Roman Shimanovich、Stephanie K. Springer、Yohannes Teffera、Yajing Yang、Yihong Zhang、Steven F. Bellon

  DOI：10.1021/jm800043g

  日期：2008.5.1

  was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. Deregulated signaling in the c-Met pathway has been observed in multiple tumor types. Herein we report the discovery of potent and selective triazolopyridazine small molecules that inhibit c-Met activity.

  肿瘤发生是一个多步骤过程，其中癌基因在肿瘤形成，生长和维持中起关键作用。MET被发现是一种被其配体肝细胞生长因子激活的致癌基因。在多种肿瘤类型中均已观察到c-Met途径中的信号转导失调。在本文中，我们报告了抑制c-Met活性的有效和选择性三唑并哒嗪小分子的发现。
• Fused heterocyclic derivatives and methods of use
  申请人：Albrecht Brian K.

  公开号：US20090124612A1

  公开（公告）日：2009-05-14

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于预防和治疗疾病，如HGF介导的疾病具有有效性。本发明包括新颖的化合物、类似物、前药和其药学上可接受的盐、药物组合物和预防和治疗涉及癌症等疾病和其他疾病或病况的方法。该发明还涉及制备这样的化合物的过程，以及在这样的过程中有用的中间体。
• FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE
  申请人：ALBRECHT Brian K.

  公开号：US20120148531A1

  公开（公告）日：2012-06-14

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的化合物对于预防和治疗疾病，如HGF介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药学上可接受的盐、制药组合物以及用于预防和治疗涉及癌症等疾病和其他疾病或病情的方法。该发明还涉及制备这种化合物的过程以及在这种过程中有用的中间体。
• [1,2,4]TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR
  申请人：Amgen, Inc

  公开号：EP3093289A1

  公开（公告）日：2016-11-16

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物可有效预防和治疗疾病，如 HGF 介导的疾病。本发明包括新型化合物、类似物、原药及其药学上可接受的盐、药物组合物以及用于预防和治疗涉及癌症等疾病和其他弊病或病症的方法。本发明还涉及制造此类化合物的工艺以及在此类工艺中有用的中间体。
• WO2008/8539
  申请人：——

  公开号：——

  公开（公告）日：——