2-fluoro-6-((4-methoxybenzyl)oxy)benzaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-fluoro-6-((4-methoxybenzyl)oxy)benzaldehyde
• 英文别名: 2-Fluoro-6-[(4-methoxyphenyl)methoxy]benzaldehyde；2-fluoro-6-[(4-methoxyphenyl)methoxy]benzaldehyde
• 化学式: C₁₅H₁₃FO₃
• 分子量: 260.265
• InChiKey: HGWSTPRYUSZRNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-fluoro-6-((4-methoxybenzyl)oxy)benzaldehyde 在 1,1'-双(二苯基膦)二茂铁 、 tris-(dibenzylideneacetone)dipalladium(0) 、 lithium hydroxide monohydrate 、 水 、 potassium carbonate 、 锌 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 3-cyano-5-{2-formyl-3-[(4-methoxyphenyl)methoxy]phenoxy}benzoic acid
  参考文献：
  名称：

  [EN] REVERSIBLE LYSINE COVALENT MODIFIERS OF EGFR AND USES THEREOF
  [FR] MODIFICATEURS COVALENTS DE LYSINE RÉVERSIBLES DE L'EGFR ET LEURS UTILISATIONS

  摘要：

  EGFR is a frequently overexpressed protein in certain human cancers. Disclosed herein are compositions and methods for the modulation EGFR proteins, specifically EGFR mutants comprising single, double, or triple mutations.

  公开号：

  WO2023070114A2
• 作为产物：
  描述：

  6-氟水杨醛 、 4-甲氧基氯苄 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以70%的产率得到2-fluoro-6-((4-methoxybenzyl)oxy)benzaldehyde
  参考文献：
  名称：

  Organocatalytic Route to Dihydrocoumarins and Dihydroquinolinones in All Stereochemical Configurations

  摘要：

  A straightforward stereodivergent route to dihydrocoumarins and dihydroquinolinones based on cinchona alkaloid catalyzed addition reactions of monothiomalonates (MTMs) to functionalized nitroolefins followed by deprotection and chemoselective cyclization has been developed. The synthesis proceeds under mild conditions and yields heterocycles with adjacent quaternary and tertiary stereogenic centers in very high yields and stereoselectivities. Moreover, full control over the relative and absolute configuration is achieved by the use of (pseudo)enantiomeric catalysts and the difference in reactivity of thioester versus oxoester moieties.

  DOI：

  10.1021/ol502697s

文献信息

• Organocatalytic Route to Dihydrocoumarins and Dihydroquinolinones in All Stereochemical Configurations
  作者：Oliver D. Engl、Sven P. Fritz、Alexander Käslin、Helma Wennemers

  DOI：10.1021/ol502697s

  日期：2014.10.17

  A straightforward stereodivergent route to dihydrocoumarins and dihydroquinolinones based on cinchona alkaloid catalyzed addition reactions of monothiomalonates (MTMs) to functionalized nitroolefins followed by deprotection and chemoselective cyclization has been developed. The synthesis proceeds under mild conditions and yields heterocycles with adjacent quaternary and tertiary stereogenic centers in very high yields and stereoselectivities. Moreover, full control over the relative and absolute configuration is achieved by the use of (pseudo)enantiomeric catalysts and the difference in reactivity of thioester versus oxoester moieties.
• [EN] REVERSIBLE LYSINE COVALENT MODIFIERS OF EGFR AND USES THEREOF<br/>[FR] MODIFICATEURS COVALENTS DE LYSINE RÉVERSIBLES DE L'EGFR ET LEURS UTILISATIONS
  申请人：[en]TERREMOTO BIOSCIENCES, INC.

  公开号：WO2023070114A2

  公开（公告）日：2023-04-27

  EGFR is a frequently overexpressed protein in certain human cancers. Disclosed herein are compositions and methods for the modulation EGFR proteins, specifically EGFR mutants comprising single, double, or triple mutations.