2-Chloro-4,4,5,5-tetramethyl-2-((Z)-2-methyl-but-2-enyl)-[1,3,2]dioxasilolane | 887136-73-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Chloro-4,4,5,5-tetramethyl-2-((Z)-2-methyl-but-2-enyl)-[1,3,2]dioxasilolane
• CAS: 887136-73-4
• 化学式: C₁₁H₂₁ClO₂Si
• 分子量: 248.825
• InChiKey: VYFUZEGOKGHDAP-CLFYSBASSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.73
• 重原子数：
  15.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-Chloro-4,4,5,5-tetramethyl-2-((Z)-2-methyl-but-2-enyl)-[1,3,2]dioxasilolane 在 甲基锂 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 95.0h， 生成 (1S,3R,4S)-1-Cyclohexyl-3,4,5-trimethyl-hex-5-ene-1,3-diol
  参考文献：
  名称：

  Tandem Aldol−Allylation and Aldol−Aldol Reactions with Ketone-Derived Enolsilanes:  Highly Diastereoselective Single-Step Synthesis of Complex Tertiary Carbinols

  摘要：

  A new tandem aldol-allylation reaction employing ketone-derived enolates has been developed that leads to the rapid, diastereoselective synthesis of tertiary carbinol containing fragments with relevance to polyketide natural product synthesis. In addition, the use of ketone-derived enolates has led to the development of a new tandem aldol-aldol reaction.

  DOI：

  10.1021/ja053593s
• 作为产物：
  描述：

  频哪醇 、 (Z)-trichloro(2-methylbut-2-en-1-yl)silane 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 2-Chloro-4,4,5,5-tetramethyl-2-((Z)-2-methyl-but-2-enyl)-[1,3,2]dioxasilolane
  参考文献：
  名称：

  Tandem Aldol−Allylation and Aldol−Aldol Reactions with Ketone-Derived Enolsilanes:  Highly Diastereoselective Single-Step Synthesis of Complex Tertiary Carbinols

  摘要：

  A new tandem aldol-allylation reaction employing ketone-derived enolates has been developed that leads to the rapid, diastereoselective synthesis of tertiary carbinol containing fragments with relevance to polyketide natural product synthesis. In addition, the use of ketone-derived enolates has led to the development of a new tandem aldol-aldol reaction.

  DOI：

  10.1021/ja053593s