Preparation of δ-Chloro-α-allenyl Ketones by Acylation of 3-Buten-1-ynes
摘要:
AlC(l)3-mediated acylation of 3-buten-1-yne derivatives with acyl chlorides yields a mixture of 5-chloro-2,3-pentadienones and 3-chloro-2,4-pentadienones. The proportion of allenyl ketones vs conjugated dienic ketones depends on the substitution pattern of the starting enyne, Acylation of 5-acetoxy-3-buten-1-ynes leads to the corresponding allenyl ketones (6-acetoxy-5-chloro-2,3-pentadienones).
AlCl3 mediated acylation of 3-buten-1-yne derivatives with acyl chlorides yields a mixture of 5-chloro-2,3-pentadienones and 3-chloro-2,4-pentadienones. The proportion of allenylketones vs conjugated dienic ketones depends on the substitution pattern of the starting enyne. Acylation of 5-acetoxy-3-buten-1-ynes leads to the corresponding allenylketones (6-acetoxy-5-chloro-2,3-pentadienones).
Melikyan, G. G.; Babayan, E. V.; Panosyan, G. A., Journal of Organic Chemistry USSR (English Translation), 1990, vol. 26, # 5.1, p. 830 - 836
作者:Melikyan, G. G.、Babayan, E. V.、Panosyan, G. A.、Palikyan, G. U.、Badanyan, Sh. O.