1-(4-(2-(9H-carbazol-9-yl)ethyl)phenyl)ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(4-(2-(9H-carbazol-9-yl)ethyl)phenyl)ethanone
• 英文别名: 1-[4-(2-Carbazol-9-ylethyl)phenyl]ethanone；1-[4-(2-carbazol-9-ylethyl)phenyl]ethanone
• 化学式: C₂₂H₁₉NO
• 分子量: 313.399
• InChiKey: HATMTOIWOYSEJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-乙烯基咔唑 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 caesium carbonate 作用下， 以 水 、 甲苯 为溶剂， 反应 12.0h， 生成 1-(4-(2-(9H-carbazol-9-yl)ethyl)phenyl)ethanone
  参考文献：
  名称：

  β-Aminoethyltrifluoroborates:  Efficient Aminoethylations via Suzuki−Miyaura Cross-Coupling

  摘要：

  A set of phenethylamines has been successfully prepared via Suzuki-Miyaura cross-coupling of diverse potassium beta-aminoethyltrifluoroborates with aryl halides. The potassium beta-aminoethyltrifluoroborates were easily prepared via hydroboration of enamine and enamide precursors.

  DOI：

  10.1021/ol062610v

文献信息

• HDAC INHIBITORS AND THERAPEUTIC METHODS OF USING SAME
  申请人：Kozikowski Alan

  公开号：US20120252740A1

  公开（公告）日：2012-10-04

  Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed.

  本文披露了组蛋白去乙酰化酶抑制剂（HDACIs）及其含量。同时还披露了治疗疾病和状况的方法，其中抑制HDAC能够提供益处，如癌症、神经退行性疾病、神经系统疾病、创伤性脑损伤、中风、疟疾、自身免疫疾病、自闭症和炎症。
• HDAC Inhibitors and Therapeutic Methods of Using Same
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

  公开号：US20130281484A1

  公开（公告）日：2013-10-24

  Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed.

  本文披露了组蛋白去乙酰化酶抑制剂（HDACIs）及其组合物。同时还披露了治疗疾病和状况的方法，其中抑制HDAC可以提供益处，例如癌症、神经退行性疾病、神经系统疾病、创伤性脑损伤、中风、疟疾、自身免疫疾病、自闭症和炎症。
• US8431538B2
  申请人：——

  公开号：US8431538B2

  公开（公告）日：2013-04-30
• US8748451B2
  申请人：——

  公开号：US8748451B2

  公开（公告）日：2014-06-10
• β-Aminoethyltrifluoroborates:  Efficient Aminoethylations via Suzuki−Miyaura Cross-Coupling
  作者：Gary A. Molander、Fabricio Vargas

  DOI：10.1021/ol062610v

  日期：2007.1.1

  A set of phenethylamines has been successfully prepared via Suzuki-Miyaura cross-coupling of diverse potassium beta-aminoethyltrifluoroborates with aryl halides. The potassium beta-aminoethyltrifluoroborates were easily prepared via hydroboration of enamine and enamide precursors.