5-oxo-heptanenitrile | 33739-93-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-oxo-heptanenitrile
• 英文别名: 5-Oxo-heptannitril；5-oxoheptane nitrile；5-Oxoheptanenitrile
• CAS: 33739-93-4
• 化学式: C₇H₁₁NO
• 分子量: 125.17
• InChiKey: YJNQITHVCLOUMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-Ethyl-2-hydroxy-cyclopentanonoxim 在 吡啶 、 甲基磺酰氯 作用下， 生成 5-oxo-heptanenitrile
  参考文献：
  名称：

  A Novel Alkylation of Alicyclic 1,2-Enediolates. A Facile Synthesis of Oxoalkanenitriles

  摘要：

  DOI：

  10.1055/s-1976-24046

文献信息

• Process for the preparation of C-substituted pyridines and/or hydrogenated C-substituted pyridines
  申请人：STAMICARBON B.V.

  公开号：EP0009289A1

  公开（公告）日：1980-04-02

  An improved process for the preparation of pyridines and/or hydrogenated pyridines that have been substituted with a hydrocarbon group at one or mor carbon atoms. y-cyanoketone, in a gaseous phase and in the presence of hydrogen, is passed in a reaction zone over a first catalyst containing a catalytically active metal or compound of a metal selected from the group copper, silver, gold, iron, nickel, cobalt, ruthenium, rhodium, palladium, osmium, iridium and platinum to form a reaction mixture. A hydrogen-containing gas is separated from the reaction mixture, passed over a second catalyst containing a catalytically active metal or compound of a metal selected from the group iron, nickel and cobalt at a temperature of between 300 and 800°C, and the hydrogen-containing gas so treated is recycled to the reaction zone.

  一种制备吡啶和/或在一个或多个碳原子上被烃基取代的氢化吡啶的改进工艺。在气相和氢气存在的情况下，y-氰基酮在反应区通过第一催化剂，该第一催化剂含有催化活性金属或选自铜、银、金、铁、镍、钴、钌、铑、钯、锇、铱和铂的金属化合物，以形成反应混合物。 从反应混合物中分离出含氢气体，在300至800℃的温度下通过第二催化剂，该第二催化剂含有催化活性金属或选自铁、镍和钴的金属化合物，经如此处理的含氢气体再循环到反应区。
• Process for the preparation of 5-oxohexane nitriles and the compound 2,4-dimethyl-5-oxohexane nitrile
  申请人：DSM N.V.

  公开号：EP0437290A1

  公开（公告）日：1991-07-17

  The invention relates to a process for the preparation of 5-oxohexane nitriles according to Formula 1, where at least R₁ or R₂ is an electron-donating group and at least one of the groups R₃, R₄ or R₅ is not hydrogen, by catalylic conversion of a methyl ketone according to Formula 2 where R₁ and R₂ denote the same as in Formula 1, and an α-β unsaturated nitrile according to Formula 3 in the presence of a strong base as a catalyst. The invention furthermore relates to the new substance 2,4-dimethyl-5-oxohexane nitrile. The obtained 5-oxohexane nitriles can be advantageously used in the preparation of 2-methylpyridines.

  本发明涉及一种根据式 1 制备 5-氧代己烷腈的工艺、 其中至少 R₁ 或 R₂ 是电子奉献基团，且至少一个基团 R₃、R₄ 或 R₅ 不是氢，通过催化转化根据式 2 的甲基酮来制备 其中 R₁ 和 R₂ 表示与式 1 相同，以及根据式 3 的 α-β 不饱和腈 在强碱作为催化剂的存在下。 本发明还涉及一种新物质 2,4-二甲基-5-氧代己烷腈。 所得到的 5-氧代己烷腈可用于制备 2-甲基吡啶。
• Simple De-airing Technique for Aortic Valve Replacement with Upper Ministernotomy
  作者：Erkan Kuralay、Ufuk Demirkiliç、Bilgehan Savaα Öz、Faruk Cingöz、Harun Tatar

  DOI：10.1111/j.1540-8191.2001.tb00526.x

  日期：2001.7

  Upper ministernotomy for aortic valve replacement is intimidating for many surgeons, not only for limited surgical exposure but also for the inability to complete de-airing the apex of the heart. Conversion to full sternotomy had been reported for this inability to de-air the apex of the heart in a limited number of cases. We describe a simple de-airing method by introducing a 16 GA catheter into the apex of the left ventricle through the aorta and prosthetic valve.
• Bruylants, Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1921, vol. <5> 7, p. 252
  作者：Bruylants

  DOI：——

  日期：——
• BROOKES, K. BRIDGET;HICKMOTT, PETER W., S. AFR. J. CHEM., 42,(1989) N, C. 20-24
  作者：BROOKES, K. BRIDGET、HICKMOTT, PETER W.

  DOI：——

  日期：——