2-(3-bromo-5-methyl-1H-pyrazol-1-yl)-3-chloropyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(3-bromo-5-methyl-1H-pyrazol-1-yl)-3-chloropyridine
• 英文别名: 3-bromo 1-(3-chloro-2-pyridyl)-5-methyl-1H-pyrazole；2-(3-Bromo-5-methylpyrazol-1-yl)-3-chloropyridine
• 化学式: C₉H₇BrClN₃
• 分子量: 272.532
• InChiKey: LCJUXFYTZVBJNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(3-bromo-5-methyl-1H-pyrazol-1-yl)-3-chloropyridine 在 N-羟基丁二酰亚胺 、 氧气 、 cobalt(II) acetate 、 manganese(II) acetate 、 溶剂黄146 作用下， 100.0~110.0 ℃ 、4.0 MPa 条件下， 反应 6.5h， 以70%的产率得到3-溴-1-(3-氯-2-吡啶)-1H-吡唑-5-羧酸
  参考文献：
  名称：

  [EN] PREPARATION OF SUBSTITUTED PYRAZOLES AND THEIR USE AS ANTHRANILAMIDES PRECURSORS
  [FR] PRÉPARATION DE PYRAZOLES SUBSTITUÉS ET LEUR UTILISATION EN TANT QUE PRÉCURSEURS D'ANTHRANILAMIDES

  摘要：

  揭示了一种制备吡唑衍生物3-溴-5-甲基-1-H-吡唑-N-2-氯吡啶（化合物I式）的方法，通过将化合物II式与卤代吡啶反应，可选地在碱和有机溶剂的存在下，或者在酸的存在下通过吡唑羧酸的脱羧制备。此外，提供了一种制备合成前体II式、IV式、V式、VI式、XI式的方法，以及一种制备化合物VII式的方法，包括将化合物I式与氧化剂反应，可选地在催化剂的存在下。还揭示了一种化合物I式作为制备方酰胺VIII式的有用合成前体的方法。

  公开号：

  WO2020212991A1
• 作为产物：
  描述：

  2-肼基-3-氯吡啶 在 potassium permanganate 、 氢溴酸 、 碳酸氢钠 、 溶剂黄146 作用下， 以 水 、 乙腈 为溶剂， 反应 29.75h， 生成 2-(3-bromo-5-methyl-1H-pyrazol-1-yl)-3-chloropyridine
  参考文献：
  名称：

  [EN] NOVEL 2-(3-HALO-5-METHYL-1 H-PYRAZOL-1-YL)-3-HALOPYRIDINE COMPOUNDS AND INTERMEDIATES THEREOF
  [FR] NOUVEAUX COMPOSÉS DE 2-(3-HALO-5-MÉTHYL-1H-PYRAZOL-1-YL)-3-HALOPYRIDINE ET LEURS INTERMÉDIAIRES

  摘要：

  本发明揭示了新型的2-(3-卤代-5-甲基-1H-吡唑-1-基)-3-卤代吡啶化合物及其中间体。同时，还提供了制备该化合物的方法。所述化合物可用作化学中间体。

  公开号：

  WO2020026260A1

文献信息

• AGRICULTURAL CHEMICALS
  申请人：Redx Pharma Ltd.

  公开号：US20150094474A1

  公开（公告）日：2015-04-02

  The present invention relates to derivatives of compounds which are known to be of use in the field of agriculture. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more changes one or more of which may be considered to represent a change of oxidation state relative to the groups in the original compound. We refer to these compounds generally as redox derivatives. The compounds are of use as insecticides, herbicides and insect repellents.

  本发明涉及与农业领域中已知有用的化合物衍生物。这些衍生物通过成为活性化合物的氧化还原衍生物而与母体活性化合物区分开来。这意味着活性化合物中的一个或多个官能团已经转化为另一个官能团，其中一个或多个转变可能被认为代表相对于原始化合物中的官能团的氧化状态的变化。我们通常将这些化合物称为氧化还原衍生物。这些化合物可用作杀虫剂、除草剂和驱虫剂。
• HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME
  申请人：Ikegami Hiroshi

  公开号：US20110071291A1

  公开（公告）日：2011-03-24

  A hydrazide compound represented by the formula (1): (wherein R 1 , R 2 , R 3 , R 4 , A 1 , A 2 , J, Q and n are defined in the specification) has excellent pesticidal activity.

  一个由公式（1）表示的腙酰肼化合物：（其中R1，R2，R3，R4，A1，A2，J，Q和n在说明书中定义）具有优异的杀虫活性。
• Hydrazide Compound and Pesticidal Use of the Same
  申请人：Ikegami Hiroshi

  公开号：US20090181956A1

  公开（公告）日：2009-07-16

  A hydrazide compound represented by the formula (1): has excellent pesticidal activity.

  一种由式（1）表示的腙酰肼类化合物具有出色的杀虫活性。
• PREPARATION OF SUBSTITUTED PYRAZOLES AND THEIR USE AS ANTHRANILAMIDES PRECURSORS
  申请人：Adama Makhteshim Ltd.

  公开号：EP3956314A1

  公开（公告）日：2022-02-23
• Novel Insecticides
  申请人：Hughes John David

  公开号：US20070281930A1

  公开（公告）日：2007-12-06

  Compounds of the formula in which Z 1 is an oxygen atom; or a sulfur atom; Z 2 is an oxygen atom; or a sulfur atom; R 1 is an aryl or heteroaryl group, which is unsubstituted or substituted; R 2 is hydrogen; or an organic substituent; R 3 is hydrogen; or an organic substituent; R 4 is hydrogen; or an organic substituent; or R 3 and R 4 , taken together, form, together with the nitrogen atom, to which they are attached, a ring, which is unsubstituted or substituted; R 5 is hydrogen; or an unsubstituted or substituted alkyl group; or forms, taken together with R 8 or with a monovalent substituent attached to that atom of R 6 , via which atom R 6 is directly connected with the carbon atom, shown in the formula I, which carries R 5 , one additional bond; R 6 and R 7 , taken together, form, together with the two carbon atoms, shown in the formula I, to which atoms they are attached, a bicyclic ring system, which ring system is carbocyclic or heterocyclic, which ring system is substituted, in the manner shown in the formula I, by the four substituents —N(R 2 )—C(=Z 1 )—R 1 , —C(=Z 2 )-N(R 3 )—R 4 , R 5 and R 8 , and which ring system is optionally further substituted; and R 8 is hydrogen; or an unsubstituted or substituted alkyl group; or forms, taken together with R 5 or with a monovalent substituent attached to that atom of R 7 , via which atom R 7 is directly connected with the carbon atom, shown in the formula I, which carries R 8 , one additional bond, and, where appropriate, tautomers thereof, in each case in free form or in salt form, can be used as agrochemical active ingredients and can be prepared in a manner known per se.