3,4-di(hexyloxy)aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3,4-di(hexyloxy)aniline
• 英文别名: 3,4-bis(hexyloxy)aniline；3,4-Dihexoxyaniline
• 化学式: C₁₈H₃₁NO₂
• 分子量: 293.45
• InChiKey: HXFUWTQOKBYORS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,4-di(hexyloxy)aniline 在 potassium carbonate 作用下， 以 吡啶 、 N,N-二甲基甲酰胺 为溶剂， 反应 121.0h， 生成
  参考文献：
  名称：

  3,4-二烷氧基苯基甲苯磺酰氨基取代酞菁的合成及QCM气敏性能

  摘要：

  八取代的金属酞菁 [M = Ni(II)、Zn(II)、Co(II) 和 Cu(II)] 在外围位置带有 3,4-二烷氧基苯基甲苯磺酰氨基，由 1,2-二氰基合成4,5-之二[(3,4-二烷氧基苯基-甲苯磺酰基氨基)甲基]苯在相应的无水金属盐存在下。在金属离子中心旁边，二烷氧基苯基部分中烷基链的长度（n = 4, 5, 6, 和 12) 变化。总共有 16 种可溶性酞菁已通过元素分析、FT-IR 和1H-NMR光谱和质谱。此外，已经使用石英晶体微量天平传感器研究了这些新化合物的气体传感特性。传感特性是根据传感器对九种不同测试分析物的响应来描述的，这些分析物包括挥发性有机化合物、有毒气体和化学战剂模拟物。讨论了金属离子中心和取代基对传感器选择性和灵敏度的影响。这些化合物在气体传感实验中表现出良好的性能，对分析物有不同的反应。借助多变量数据探索方法，已在一组传感器中鉴定出对极性分析物、碳氢化合物或胺具有显着选择性的酞菁物种。

  DOI：

  10.1142/s1088424619501906
• 作为产物：
  描述：

  1,2-二己氧基苯 在 palladium on activated charcoal 、 硝酸 作用下， 生成 3,4-di(hexyloxy)aniline
  参考文献：
  名称：

  3,4-二烷氧基苯基甲苯磺酰氨基取代酞菁的合成及QCM气敏性能

  摘要：

  八取代的金属酞菁 [M = Ni(II)、Zn(II)、Co(II) 和 Cu(II)] 在外围位置带有 3,4-二烷氧基苯基甲苯磺酰氨基，由 1,2-二氰基合成4,5-之二[(3,4-二烷氧基苯基-甲苯磺酰基氨基)甲基]苯在相应的无水金属盐存在下。在金属离子中心旁边，二烷氧基苯基部分中烷基链的长度（n = 4, 5, 6, 和 12) 变化。总共有 16 种可溶性酞菁已通过元素分析、FT-IR 和1H-NMR光谱和质谱。此外，已经使用石英晶体微量天平传感器研究了这些新化合物的气体传感特性。传感特性是根据传感器对九种不同测试分析物的响应来描述的，这些分析物包括挥发性有机化合物、有毒气体和化学战剂模拟物。讨论了金属离子中心和取代基对传感器选择性和灵敏度的影响。这些化合物在气体传感实验中表现出良好的性能，对分析物有不同的反应。借助多变量数据探索方法，已在一组传感器中鉴定出对极性分析物、碳氢化合物或胺具有显着选择性的酞菁物种。

  DOI：

  10.1142/s1088424619501906

文献信息

• The Synthesis of Imidazo[1,2-f]phenanthridines, Phenanthro-[9,10-d]imidazoles, and Phenanthro[9′,10′:4,5]imidazo[1,2-f]-phenanthridines via Intramolecular Oxidative Aromatic Coupling
  作者：Kamil Skonieczny、Jarosław Jaźwiński、Daniel Gryko

  DOI：10.1055/s-0036-1589053

  日期：2017.10

  phenanthro[9′,10′:4,5]imidazo[1,2-f]phenanthridines. Starting from bis-aldehydes that are derivatives of thieno[3,2-b]thiophene and fluorene enabled the synthesis of π-expanded imidazoles bearing 8-9 conjugated rings. By placing a dimethoxynaphthalene unit on the imidazole scaffold, we have directed the oxidative coupling reaction towards closing a five-membered ring with concomitant removal of methoxy group

  作为“杂环合成的现代策略”专题的一部分发布 抽象的 可以快速有效地获得菲[9,10- d ]咪唑，咪唑并[1,2- f ]菲啶和菲[9'，10'：4,5]咪唑[1,2- f ]菲啶通过[双（三氟乙酰氧基）碘]苯（PIFA）对适当取代的四芳基-咪唑的作用。通过预先安装合适的给电子基团，可以控制分子内氧化性芳族偶联的位点。特别地，通过将​​3，4-二甲氧基苯基和3-甲氧基苯基部分紧密相邻，可以指导反应形成两个联芳基键，最终导致菲咯[9'，10'：4,5]咪唑的形成。 [1,2- f ]菲啶。从作为噻吩并[3,2- b的衍生物的双醛开始]噻吩和芴能够合成带有8-9个共轭环的π扩展咪唑。通过在咪唑支架上放置二甲氧基萘单元，我们指导氧化偶联反应趋向于关闭五元环，同时除去甲氧基，导致形成α，β-不饱和酮。所有得到的π膨胀咪唑均显示蓝色发射，在某些情况下，荧光量子产率达到0.9。 可以快速有效地获得菲[9
• HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS
  申请人：An Haoyun

  公开号：US20090048271A1

  公开（公告）日：2009-02-19

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  申请人：Muto Susumu

  公开号：US20060100257A1

  公开（公告）日：2006-05-11

  A medicament inhibiting the activation of AP-1 which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

  一种药物，抑制AP-1的激活，其活性成分为以下通式（I）所表示的化合物或其药学上可接受的盐、水合物或溶剂化物中所选的一种，其中X代表连接基，其主链中的原子数为2至5（该连接基可以被取代），A代表氢原子或乙酰基，E代表芳基或取代的杂芳基，环Z代表芳烃，除了由式—O-A所表示的基团外，可能还有一个或多个取代基，其中A具有上述定义的相同含义，由式—X-E所表示的基团中，X和E的每一个具有上述定义的相同含义，或者是一个杂芳烃，可能还有一个或多个取代基，其中A具有上述定义的相同含义，由式—X-E所表示的基团中，X和E的每一个具有上述定义的相同含义。
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  申请人：Muto Susumu

  公开号：US20060111409A1

  公开（公告）日：2006-05-25

  A medicament for preventive and/or therapeutic treatment of diabetes or complications of diabetes which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula —O— A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

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  申请人：Muto Susumu

  公开号：US20060122243A1

  公开（公告）日：2006-06-08

  A medicament for the preventive and/or therapeutic treatment of allergic diseases and/or endometriosis and/or hysteromyoma which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

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