dibenzoyl tetrasulfide | 59275-85-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dibenzoyl tetrasulfide
• 英文别名: BzS4Bz；dibenzoyl-tetrasulfane；Dibenzoyl-tetrasulfan；Dibenzoyltetrasulfid；(Tetrasulfane-1,4-diyl)bis(phenylmethanone)；S-(benzoyltrisulfanyl) benzenecarbothioate
• CAS: 59275-85-3
• 化学式: C₁₄H₁₀O₂S₄
• 分子量: 338.496
• InChiKey: XTDHBAVVPOKCKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  135
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  dibenzoyl tetrasulfide 在 硫代苯甲酸钾盐 、 氯仿 作用下， 生成 苯甲酰基二硫化物
  参考文献：
  名称：

  Removal of the connector on the laryngeal mask airway provides a useful alternative to the intubating laryngeal mask

  摘要：

  Purpose: We describe two cases in which fiberoptic intubation through the standard laryngeal mask airway (LMA) was successful with large-bore tracheal tubes (TTs) when an intubating LMA (ILMA) could not be used.Clinical features: Patient #, with obstructive sleep apnea, underwent elective surgical repair. His mouth opening was just under 25 mm, but difficult intubation was not anticipated. We induced general anesthesia, easily ventilated the patient by mask, and established neuromuscular blockade. Direct laryngoscopy and attempts to insert either a #5 or a #4 ILMA into the mouth failed. A standard #4 LMA, with the connector removed, was inserted, through which a 7.0 mm nasal RAE (TM) TT; fiberoptically guided, passed into the trachea at the first attempt. Patient #2, with a loosened implant after left hip arthroplasty, underwent revision prosthesis. Her neck movement was limited. We thus planned awake securing of the airway, but the patient refused. We induced anesthesia and established bag-mask-valve ventilation. The limited neck movement prevented direct laryngoscopy. Visualizing the laryngeal inlet with the fiberoptic bronchoscope (FOB) proved impossible as bloody secretions obscured the FOB's tip. Ventilation by mask was easy. As an ILMA was not available, we removed a #5 LMA's connector and passed an 8.0 mm nasal RAE (TM) TT through the LMA. fiberoptic-guided intubation was easy, In both cases, the remainder of the intraoperative course was uneventful.Conclusion: A standard LMA whose connector has been removed to allow passage of TTs of >6.0 mm internal diameter may be substituted for the ILMA when necessary.

  DOI：

  10.1007/bf03016839
• 作为产物：
  描述：

  苯甲酰基二硫化物 在 四氯化碳 、 氯 作用下， 生成 dibenzoyl tetrasulfide
  参考文献：
  名称：

  Boehme; Clement, Justus Liebigs Annalen der Chemie, 1952, vol. 576, p. 61,67

  摘要：

  DOI：
• 作为试剂：
  描述：

  三甲氧基磷 在 dibenzoyl tetrasulfide 作用下， 以 氘代氯仿 为溶剂， 生成 O,O,O-三甲基巯基磷酸酯
  参考文献：
  名称：

  Dibenzoyl tetrasulphide - A rapid sulphur transfer agent in the synthesis of phosphorothioate analogues of oligonucleotides

  摘要：

  Dibenzoyl tetrasulphide (6), an easily prepared crystalline solid, has been found to be a fast and efficient sulphur-transfer agent in the solid phase synthesis of phosphorothioate analogues of oligodeoxyribonucleotides from phosphoramidite building blocks.

  DOI：

  10.1016/s0040-4039(00)61299-6

文献信息

• Universal building blocks and support media for synthesis of oligonucleotides and their analogs
  申请人：——

  公开号：US20040152905A1

  公开（公告）日：2004-08-05

  Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

  提供用于合成寡聚化合物，特别是寡核苷酸和化学修饰的寡核苷酸类似物的化合物。此外，还提供了将支持介质功能化为第一单体亚基的方法，以及利用与支持介质结合的新化合物合成寡聚化合物的方法。
• Labeled oligonucleotides, methods for making same, and compounds useful therefor
  申请人：——

  公开号：US20030208061A1

  公开（公告）日：2003-11-06

  Selectively functionalized oligonucleotides, methods for making same, and compounds useful therefor are disclosed. The oligonucleotides can be selectively functionalized with a first conjugate group at the 3′-terminial position and optionally functionalized with a second conjugate group at the 5′-terminal position and/or one or more internucleotides. Alternatively, the oligonucleotides can be selectively functionalized with a first conjugate group at the 5′-terminal position and optionally functionalized with a second conjugate group at one or more internucleotides. In yet another embodiment, the oligonucleotides can be functionalized with a first conjugate group at one or more internucleotides and with a second conjugate group at one or more different internucleotides.

  选择性功能化寡核苷酸，制备方法以及用于此目的的化合物已被披露。这些寡核苷酸可以在3'-末端位置选择性地与第一共轭基团功能化，并可选择性地在5'-末端位置和/或一个或多个核苷酸之间与第二共轭基团功能化。另外，这些寡核苷酸可以在5'-末端位置选择性地与第一共轭基团功能化，并可选择性地在一个或多个核苷酸之间与第二共轭基团功能化。在另一实施方式中，这些寡核苷酸可以在一个或多个核苷酸之间与第一共轭基团功能化，并在一个或多个不同的核苷酸之间与第二共轭基团功能化。
• Protection of nucleosides
  申请人：——

  公开号：US20040158055A1

  公开（公告）日：2004-08-12

  A process of manufacturing protected nucleosides comprises reacting a nucleoside with a protecting reagent in the presence of a regioselective activator to produce a regioselectively protected nucleoside. In some embodiments of the inventive method, an optionally substituted trityl or optionally substituted pixyl group is selectively added to the 5′-O-position of a nucleoside in the presence of lutidine as activator or activator/solvent. The inventive method results in improved selectivity of the 5′-O-position over the 3′-O-position, thereby improving overall product yield and purity, and permitting simplified purification protocols, in some cases obviating the need for chromatography to produce a purified protected nucleoside suitable for automated synthesis of oligonucleotides, such as primers, probes and antisense molecules.

  制造受保护核苷的过程包括在具有区域选择性活化剂的存在下，将核苷与保护试剂反应，以产生区域选择性受保护核苷。在本发明方法的一些实施例中，可选择地将一个可选取代的三苯甲基或可选择地取代的哌啶基团选择性地添加到核苷的5'-O-位置，同时存在卢替啶作为活化剂或活化剂/溶剂。这种创新方法导致了对5'-O-位置的选择性提高，从而提高了整体产物产量和纯度，并允许简化的纯化方案，在某些情况下，无需色谱法即可生产适用于寡核苷酸的自动合成的纯化受保护核苷，例如引物、探针和反义分子。
• [EN] TECHNOLOGIES USEFUL FOR OLIGONUCLEOTIDE PREPARATION<br/>[FR] TECHNOLOGIES UTILES POUR LA PRÉPARATION D'OLIGONUCLÉOTIDES
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2020191252A1

  公开（公告）日：2020-09-24

  Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.

  除其他事项外，本公开提供了寡核苷酸制备技术，特别是手性控制的寡核苷酸制备技术，这些技术大大提高了粗品纯度和产量，并显著降低了制造成本。
• PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS
  申请人：Dellinger Douglas J.

  公开号：US20100076183A1

  公开（公告）日：2010-03-25

  A nucleoside monomer that is protected by a thionocarbamate protecting group is provided, as well as a method for making a polynucleotide that uses the same. Also provided is a polynucleotide synthesis method that employs a diamine to deprotect a protected polynucleotide.

  提供了一种由硫代氨基甲酸酯保护基保护的核苷单体，以及使用该核苷单体制备多核苷酸的方法。还提供了一种利用二胺去保护受保护多核苷酸的多核苷酸合成方法。