2-(苄氧基)-4-硝基苯酚 | 50352-33-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(苄氧基)-4-硝基苯酚
• 英文名称: 2-benzyloxy-4-nitrophenol
• 英文别名: 2-Benzyloxy-4-nitro-phenol；(5-Nitro-2-hydroxy-phenyl)-benzyl-aether；5-Nitro-2-hydroxy-1-benzyloxy-benzol；2-(benzyloxy)-4-nitrophenol；4-Nitro-2-benzyloxy-phenol；4-nitro-2-phenylmethoxyphenol
• CAS: 50352-33-5
• 化学式: C₁₃H₁₁NO₄
• 分子量: 245.235
• InChiKey: STAAMFWKDIAVEO-UHFFFAOYSA-N

物化性质

• 熔点：
  83-85 °C
• 沸点：
  440.5±35.0 °C(Predicted)
• 密度：
  1.329±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2909500000

反应信息

• 作为反应物：
  描述：

  2-(苄氧基)-4-硝基苯酚 在 platinum(IV) oxide 氢气 、 铜 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 3-(benzyloxy)-4-phenoxyaniline
  参考文献：
  名称：

  New non peptidic C5a receptor antagonists

  摘要：

  A series of phenylguanidines which bind to the C5a receptor has been developed. The lead compound 1 (IC50=30 mu M), discovered through random screening, has been modified to provide 32 (RPR121154) with submicromolar activity. This compound was shown to further elicit functional antagonism in a human neutrophil C5a stimulated respiratory burst assay. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00124-8
• 作为产物：
  描述：

  2-甲氧基-5-硝基苯酚 在 四丁基溴化铵 、 sodium hydroxide 作用下， 以 水 、 二甲基亚砜 、 甲苯 为溶剂， 反应 8.0h， 生成 2-(苄氧基)-4-硝基苯酚
  参考文献：
  名称：

  WO2008/118935

  摘要：

  公开号：

文献信息

• Preparation and unequivocal identification of the regioisomers of nitrocatechol monobenzyl ether
  作者：Cristiano Bolchi、Francesco Bavo、Marco Pallavicini

  DOI：10.1080/00397911.2017.1334919

  日期：2017.8.18

  The four positional isomers of nitrocatechol monobenzyl ether were prepared as intermediates to nitrobenzodioxanes directly from 2-benzyloxyphenol or, through two-four steps, from catechol. These preparations addressed the issue of the certain identification of the nitration products prescinding from chemical correlation to the synthetic precursors because the positional isomers are very similar for

  摘要 硝基邻苯二酚单苄基醚的四种位置异构体是直接从 2-苄氧基苯酚或通过两到四步从邻苯二酚制备硝基苯并二恶烷的中间体。这些制剂解决了硝化产物的某些鉴定问题，这取决于与合成前体的化学相关性，因为位置异构体在某些性质上非常相似，而且文献中可获得的分析数据在很大程度上是不完整的，不是结论性的。这里提供的 NMR、DSC 和酸度数据明确地区分每种硝基儿茶酚单苄基醚与其区域异构体。图形概要
• COMPOUNDS AND PROCESSES FOR PREPARING SUBSTITUTED AMINOMETHYL-2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-e]INDOL-8-ONES
  申请人：Wang Zhe-qing

  公开号：US20100217012A1

  公开（公告）日：2010-08-26

  Processes and intermediates are provided for the preparation of substituted aminomethyl 2,3,8,9-tetrahydiO-7H-1,4-dioxino[2.3-e]indo]-8-ones of the Formula (A) wherein the variables n, R and R 3 are as described herein. Such compounds are useful, for example, as dopamine receptor agonists.

  提供了制备取代氨甲基2,3,8,9-四氢O-7H-1,4-二氧杂[2.3-e]吲哚-8-酮（式（A））的过程和中间体，其中变量n，R和R3如本文所述。例如，这些化合物可用作多巴胺受体激动剂。
• Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-ones
  申请人：Wang Zhe-qing

  公开号：US08466296B2

  公开（公告）日：2013-06-18

  Processes and intermediates are provided for the preparation of substituted aminomethyl 2,3,8,9-tetrahydiO-7H-1,4-dioxino[2.3-e]indo]-8-ones of the Formula (A) wherein the variables n, R and R3 are as described herein. Such compounds are useful, for example, as dopamine receptor agonists.

  提供了制备取代氨甲基2,3,8,9-四氢-7H-1,4-二噁烷[2.3-e]吲哚-8-酮（公式（A）中的变量n，R和R3如本文所述）的过程和中间体。例如，这些化合物可用作多巴胺受体激动剂。
• Berti, Gazzetta Chimica Italiana, 1957, vol. 87, p. 659,670
  作者：Berti

  DOI：——

  日期：——
• Synthesis and biological activity of KCB-328 and its analogues: Novel class III antiarrhythmic agents with little reverse frequency dependence
  作者：Dong-Ick Kim、Hak-Yeop Kim、Lae-Sung Kwon、Sung-Dae Park、Gee-Ho Jeon、Kyung-Yun Jung、Jae-Ki Min、Woong-Hyun Nam、Kiho Lee、You-Sup Chung、Shigeru Tanabe、Toshiro Kozono

  DOI：10.1016/s0960-894x(98)00689-1

  日期：1999.1

  A series of 3,4-dimethoxyphenethylamine derivatives was prepared, and their prolongation effects on effective refractory period of contractile response (ERPc) and action potential duration (APD) in isolated guinea-pig papillary muscles at 1 Hz and 3 Hz were examined. SAR studies led to the identification of KCB-328 (51) which is a novel class III antiarrhythmic agent with little reverse frequency dependence. (C) 1998 Elsevier Science Ltd. All rights reserved.