4,5-Dimethyl-2-(5-methylthiophen-2-yl)-3-oxido-1,3-oxazol-3-ium | 866718-45-8

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 4,5-Dimethyl-2-(5-methylthiophen-2-yl)-3-oxido-1,3-oxazol-3-ium
• CAS: 866718-45-8
• 化学式: C₁₀H₁₁NO₂S
• 分子量: 209.269
• InChiKey: IYSFZIVMFLPUOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  66.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,5-Dimethyl-2-(5-methylthiophen-2-yl)-3-oxido-1,3-oxazol-3-ium 在 三氯氧磷 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 14.0h， 生成 4-chloromethyl-5-methyl-2-(5-methylthiophen-2-yl)oxazol
  参考文献：
  名称：

  Revisiting glitazars: Thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents

  摘要：

  In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, novel thiophene substituted oxazole containing alpha-alkoxy-phenylpropanoic acid derivatives are designed as highly potent PPAR alpha/gamma dual agonists. These compounds were found to be efficacious at picomolar concentrations. Lead compound 18d has emerged as very potent PPAR alpha/gamma dual agonist demonstrating potent antidiabetic and lipid lowering activity at a very low dose and did not exhibit any significant signs of toxicity in rodents. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.020
• 作为产物：
  描述：

  5-甲基-2-噻吩甲醛 、 二乙酰一肟 在 盐酸 、 溶剂黄146 作用下， 反应 1.0h， 生成 4,5-Dimethyl-2-(5-methylthiophen-2-yl)-3-oxido-1,3-oxazol-3-ium
  参考文献：
  名称：

  Revisiting glitazars: Thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents

  摘要：

  In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, novel thiophene substituted oxazole containing alpha-alkoxy-phenylpropanoic acid derivatives are designed as highly potent PPAR alpha/gamma dual agonists. These compounds were found to be efficacious at picomolar concentrations. Lead compound 18d has emerged as very potent PPAR alpha/gamma dual agonist demonstrating potent antidiabetic and lipid lowering activity at a very low dose and did not exhibit any significant signs of toxicity in rodents. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.020