2-氯-5-甲基-4-(噻吩-2-基)嘧啶 | 131022-67-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-氯-5-甲基-4-(噻吩-2-基)嘧啶
• 英文名称: 2-chloro-5-methyl-4-(2'-thienyl)pyrimidine
• 英文别名: 2-Chloro-5-methyl-4-(thiophen-2-yl)pyrimidine；2-chloro-5-methyl-4-thiophen-2-ylpyrimidine
• CAS: 131022-67-8
• 化学式: C₉H₇ClN₂S
• 分子量: 210.687
• InChiKey: LVXXKFMUNYGYFT-UHFFFAOYSA-N

物化性质

• 沸点：
  355.4±27.0 °C(Predicted)
• 密度：
  1.326±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  2-氯-5-甲基-4-(噻吩-2-基)嘧啶 在 吡啶 、 溶剂黄146 、 肼 作用下， 以 乙醇 为溶剂， 反应 5.0h， 生成 methyl 5-(methoxymethyl)-1-[5-methyl-4-(thiophen-2-yl)pyrimidin-2-yl]-1H-pyrazole-4-carboxylate
  参考文献：
  名称：

  Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes

  摘要：

  GPR142 is a G protein-coupled receptor that is predominantly expressed in pancreatic beta-cells. GPR142 agonists stimulate insulin secretion in the presence of high glucose concentration, so that they could be novel insulin secretagogues with reduced or no risk of hypoglycemia. We report here the optimization of HTS hit compound 1 toward a proof of concept compound 33, which showed potent glucose lowering effects during an oral glucose tolerance test in mice and monkeys.

  DOI：

  10.1021/ml400186z
• 作为产物：
  描述：

  2-Chloro-5-methyl-4-thiophen-2-yl-1,4-dihydropyrimidine 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.25h， 生成 2-氯-5-甲基-4-(噻吩-2-基)嘧啶
  参考文献：
  名称：

  Strekowski, Lucjan; Harden, Donald B.; Grubb, William B., Journal of Heterocyclic Chemistry, 1990, vol. 27, # 5, p. 1393 - 1400

  摘要：

  DOI：

文献信息

• [EN] ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS<br/>[FR] ANILINOPYRIMIDINES EN TANT QU'INHIBITEURS DE KINASES JAK
  申请人：TARGEGEN INC

  公开号：WO2009046416A1

  公开（公告）日：2009-04-09

  Provided herein are pyrimidine compounds, and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.

  本发明提供了嘧啶化合物及其制备和使用方法。这些化合物可用于治疗炎症或骨髓增生性疾病。本发明还提供了治疗癌症的方法。
• WO2008/45484
  申请人：——

  公开号：——

  公开（公告）日：——
• Chiral discrimination in binding of enantiomers of 2-(aminoalkoxy)-substituted 4-(2-thienyl)pyrimidines and 4,6-bis(2-thienyl)pyrimidines with duplex DNA
  作者：Lucjan Strekowski、Marek T. Cegla、Vidya Honkan、Henryk Buczak、W. Rucks Winkeljohn、Alfons L. Baumstark、W. David Wilson

  DOI：10.1016/j.bmcl.2005.04.004

  日期：2005.6

  Thienylpyrimidines substituted at position 2 of the pyrimidine with a chiral aminoalkoxy group were synthesized. Upon interaction with duplex DNA, the unfused heteroaromatic system of these compounds intercalates with DNA base pairs and the protonated side chain is located in the major groove. The S-enantiomers bind more strongly than their R-counterparts with enantiomeric discrimination, as measured by a ratio of binding constants K-S/K-R, ranging from 1.2 to 2.4. (c) 2005 Elsevier Ltd. All rights reserved.
• Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes
  作者：Narihiro Toda、Xiaolin Hao、Yasuyuki Ogawa、Kozo Oda、Ming Yu、Zice Fu、Yi Chen、Yongjae Kim、Mike Lizarzaburu、Sarah Lively、Shauna Lawlis、Michiko Murakoshi、Futoshi Nara、Nobuaki Watanabe、Jeff D. Reagan、Hui Tian、Angela Fu、Alykhan Motani、Qingxiang Liu、Yi-Jyun Lin、Run Zhuang、Yumei Xiong、Peter Fan、Julio Medina、Leping Li、Masanori Izumi、Ryo Okuyama、Satoshi Shibuya

  DOI：10.1021/ml400186z

  日期：2013.8.8

  GPR142 is a G protein-coupled receptor that is predominantly expressed in pancreatic beta-cells. GPR142 agonists stimulate insulin secretion in the presence of high glucose concentration, so that they could be novel insulin secretagogues with reduced or no risk of hypoglycemia. We report here the optimization of HTS hit compound 1 toward a proof of concept compound 33, which showed potent glucose lowering effects during an oral glucose tolerance test in mice and monkeys.
• Strekowski, Lucjan; Harden, Donald B.; Grubb, William B., Journal of Heterocyclic Chemistry, 1990, vol. 27, # 5, p. 1393 - 1400
  作者：Strekowski, Lucjan、Harden, Donald B.、Grubb, William B.、Patterson, Steven E.、Czarny, Agnieszka、et al.

  DOI：——

  日期：——