N,N-Dimethyl-N'-dodecanoyl-N'-methyl-1,3-propylenediamine | 153204-04-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N-Dimethyl-N'-dodecanoyl-N'-methyl-1,3-propylenediamine
• 英文别名: N-[3-(dimethylamino)propyl]-N-methyldodecanamide
• CAS: 153204-04-7
• 化学式: C₁₈H₃₈N₂O
• 分子量: 298.513
• InChiKey: KKSYAUGRBKVXRF-UHFFFAOYSA-N

物化性质

• 沸点：
  397.1±25.0 °C(Predicted)
• 密度：
  0.885±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  sodium monochloroacetic acid 、 N,N-Dimethyl-N'-dodecanoyl-N'-methyl-1,3-propylenediamine 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  A Combination of β-Aescin and Newly Synthesized Alkylamidobetaines as Modern Components Eradicating the Biofilms of Multidrug-Resistant Clinical Strains of Candida glabrata

  摘要：

  The current trend in microbiological research aimed at limiting the development of biofilms of multidrug-resistant microorganisms is increasingly towards the search for possible synergistic effects between various compounds. This work presents a combination of a naturally occurring compound, β-aescin, newly synthesized alkylamidobetaines (AABs) with a general structure—CnTMDAB, and antifungal drugs. The research we conducted consists of several stages. The first stage concerns determining biological activity (antifungal) against selected multidrug-resistant strains of Candida glabrata (C. glabrata) with the highest ability to form biofilms. The second stage of this study determined the activity of β-aescin combinations with antifungal compounds and alkylamidobetaines. In the next stage of this study, the ability to eradicate a biofilm on the polystyrene surface of the combination of β-aescin with alkylamidobetaines was examined. It has been shown that the combination of β-aescin and alkylamidobetaine can firmly remove biofilms and reduce their viability. The last stage of this research was to determine the safety regarding the cytotoxicity of both β-aescin and alkylamidobetaines. Previous studies on the fibroblast cell line have shown that C9 alkylamidobetaine can be safely used as a component of anti-biofilm compounds. This research increases the level of knowledge about the practical possibilities of using anti-biofilm compounds in combined therapies against C. glabrata.

  DOI：

  10.3390/ijms25052541
• 作为产物：
  描述：

  月桂酰氯 、 碳酸氢钠 、 三甲基-1,3-丙二胺 在 N,N-二异丙基乙胺 作用下， 以 氯仿 、 水 为溶剂， 生成 N,N-Dimethyl-N'-dodecanoyl-N'-methyl-1,3-propylenediamine
  参考文献：
  名称：

  Use of amidoamines in ophthalmic compositions

  摘要：

  描述了使用某些酰胺胺类化合物来消毒隐形眼镜并保存眼科制剂。还描述了含有这些化合物作为消毒剂或防腐剂的眼科制剂。本发明中使用的酰胺胺类化合物具有强大的抗菌和抗真菌活性，并且与眼科制剂中使用的无机离子和其他材料在化学上兼容。

  公开号：

  US05573726A1

文献信息

• USE OF AMIDOAMINES IN OPHTHALMIC COMPOSITIONS
  申请人：ALCON LABORATORIES, INC.

  公开号：EP0757560A1

  公开（公告）日：1997-02-12
• OPHTHALMIC COMPOSITIONS COMPRISING AMIDOAMINES
  申请人：ALCON LABORATORIES, INC.

  公开号：EP0757560B1

  公开（公告）日：1999-12-22
• US5573726A
  申请人：——

  公开号：US5573726A

  公开（公告）日：1996-11-12
• [EN] 1,3,-PROPANEDIAMINE DERIVATIVES HAVING PROTEIN KINASE C INHIBITORY ACTIVITY<br/>[FR] DERIVES DE 1,3,-PROPANEDIAMINE AYANT UNE ACTIVITE D'INHIBITION DE LA PROTEINE KINASE C
  申请人：SPHNIX PHARMACEUTICALS CORPORATION

  公开号：WO1993020813A1

  公开（公告）日：1993-10-28

  (EN) Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and: (a) a compound having formula (I), wherein m is 2, 3 or 4; R1, R2 and R3 are, independently, C1 to about C20 alkyl, C1 to about C20 alkenyl, or C1 to about C20 alkynyl; and R4 is C8 to about C20 alkyl; or (b) a compound having formula (II), wherein n is 1, 2, 3 or 4; R5 and R6 are, independently, C1 to about C5 alkyl, C1 to about C5 alkenyl, or C1 to about C5 alkynyl; and R7 is C8 to about C20 alkyl; or (c) pharmaceutically acceptable salt of (a) or (b). The pharmaceutical compositions are useful for inhibiting protein kinase C and treating conditions related to or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.(FR) Compositions pharmaceutiques comprenant un excipient ou diluant pharmaceutiquement acceptable et (a) un composé de la formule (I) dans lequel m est 2, 3 ou 4; R1, R2 et R3 sont, indépendamment, alkyle C1 à environ C20, alcényle C1 à environ C20 ou alcynyle C1 à environ C20; et R4 est alkyle C8 à environ C20; ou (b) un composé de la formule (II) dans laquelle n est 1, 2, 3 ou 4; R5 et R6 sont, indépendamment, alkyle C1 à environ C5, alcényle C1 à environ C5 ou alcynyle C1 à environ C5; et R7 est alkyle C8 à environ C20; ou (c) un sel pharmaceutiquement acceptable de (a) ou (b). Lesdites compositions pharmaceutiques sont utilisées pour inhiber la protéine kinase C et traiter des pathologies liées à l'inhibition de la protéine kinase C ou influencées par cette inhibition, en particulier les tumeurs cancéreuses, les maladies inflammatoires, les blessures de reperfusion et les dysfonctionnements cardiaques liées aux blessures de reperfusion.
• [EN] USE OF AMIDOAMINES IN OPHTHALMIC COMPOSITIONS<br/>[FR] UTILISATION D'AMIDOAMINES DANS DES COMPOSITIONS OPHTALMIQUES
  申请人：——

  公开号：WO1996026747A2

  公开（公告）日：1996-09-06

  [EN] The use of certain amidoamines to disinfect contact lenses and preserve ophthalmic compositions is described. Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described. The amidoamines utilized in the present invention have potent antibacterial and antifungal activity, and are chemically compatible with inorganic ions and other materials utilized in ophthalmic compositions.
  [FR] L'invention concerne l'utilisation de certaines amidoamines pour désinfecter des lentilles de contact et conserver des compositions ophtalmiques. L'invention traite également de compositions ophtalmiques contenant ces composés comme agents désinfectants ou conservateurs. Les amidoamines utilisées dans la présente invention présentent une puissante activité antibactérienne et antifongique, et sont chimiquement compatibles avec des ions inorganiques et d'autres matériaux utilisés dans des compositions ophtalmiques.