ethyl 2-[4-(4-chlorobenzyl)phenoxy]propanoate | 57125-30-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-[4-(4-chlorobenzyl)phenoxy]propanoate
• 英文别名: (+-)-Ethyl 2-(4-(4-chlorobenzyl)phenoxy)propionate；ethyl 2-[4-[(4-chlorophenyl)methyl]phenoxy]propanoate
• CAS: 57125-30-1
• 化学式: C₁₈H₁₉ClO₃
• 分子量: 318.8
• InChiKey: FQHOIQKIIWSQPG-UHFFFAOYSA-N

物化性质

• 沸点：
  416.2±30.0 °C(Predicted)
• 密度：
  1.160±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 2-[4-(4-chlorobenzyl)phenoxy]propanoate 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 fenofibric acid
  参考文献：
  名称：

  Thiele; Ahmed; Jahn, Arzneimittel-Forschung/Drug Research, 1979, vol. 29, # 5, p. 711 - 720

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-di-tert-butyl-4-(4-chlorobenzylidene)cyclohexa-2,5-dien-1-one 在 aluminum (III) chloride 、 二氢吡啶 、 三(五氟苯基)硼烷 、 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 13.0h， 生成 ethyl 2-[4-(4-chlorobenzyl)phenoxy]propanoate
  参考文献：
  名称：

  B（C 6 F 5）3催化对-醌甲基化物和紫红色还原，以得到不对称的二芳基甲烷和三芳基甲烷：精制为溴酸盐

  摘要：

  已开发出一种温和有效的方法，该方法通过使用Hantzsch酯作为还原源，通过B（C 6 F 5）3分别催化对苯醌甲基化物和丁二酮的还原反应，合成不对称的二芳基甲烷和三芳基甲烷。详细的机械研究表明，该反应实际上是通过衍生自B（C 6 F 5）3和汉茨（Hantzsch）酯的路易斯酸-碱对络合物进行的。

  DOI：

  10.1039/c7ob02007d

文献信息

• Herbicidal agents
  申请人：Hoechst Aktiengesellschaft

  公开号：US04088474A1

  公开（公告）日：1978-05-09

  Compounds of the formula ##STR1## WHEREIN R is halogen, (C.sub.1 -C.sub.4)alkyl, halo-(C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, halo(C.sub.1 -C.sub.4)alkoxy, phenyl, --NO.sub.2, --NH.sub.2 or --CN; R' is (C.sub.1 -C.sub.4)alkyl or halogen; n is an integer of from 1 to 3; n.sub.1 is zero or an integer of from 1 to 3; Y is (C.sub.1 -C.sub.6)alkylene and X is --COOH, --COO--(C.sub.1 -C.sub.8)alkyl, --CONH.sub.2, --CONH--NH.sub.2, --CN or --COO--Cat, "Cat" being the cation of an inorganic or organic base, are useful as selective grass herbicides.

  该化合物的化学式为##STR1##其中R是卤素，(C.sub.1 -C.sub.4)烷基，卤代(C.sub.1 -C.sub.4)烷基，(C.sub.1 -C.sub.4)烷氧基，卤代(C.sub.1 -C.sub.4)烷氧基，苯基，--NO.sub.2，--NH.sub.2或--CN; R'是(C.sub.1 -C.sub.4)烷基或卤素; n是1至3的整数; n.sub.1为零或1至3的整数; Y是(C.sub.1 -C.sub.6)烷基，X是--COOH，--COO--(C.sub.1 -C.sub.8)烷基，--CONH.sub.2，--CONH--NH.sub.2，--CN或--COO--Cat，“Cat”是无机或有机碱的阳离子，可用作选择性草药杀虫剂。
• Synthesis of Diarylmethanes via Pd-Catalyzed Coupling of Aryltosylates with Benzyltitanium Reagents
  作者：He Zhang

  DOI：10.1134/s1070363222070246

  日期：2022.7

  Abstract Two new bidentate phosphate ligands have been synthesized by Pd-catalyzed coupling reactions, characterized and evaluated. An efficient and simple Pd-catalyzed synthetic method for diarylmethane derivatives in good to high yields and two new diarylmethanes is reported for the first time. It provides a wide range of substrates and exhibits good functional group tolerance. This method has been

  摘要 通过 Pd 催化的偶联反应合成了两种新的双齿磷酸盐配体，并对其进行了表征和评估。首次报道了一种高效且简单的 Pd 催化合成二芳基甲烷衍生物的方法，该方法具有良好至高收率和两种新的二芳基甲烷。它提供了广泛的底物，并表现出良好的官能团耐受性。该方法已用于 Beclobrate 药物的合成，有望在药物合成及相关领域找到各种应用。
• Glucose Transport-Enhancing and Hypoglycemic Activity of 2-Methyl-2-phenoxy-3-phenylpropanoic Acids
  作者：Reinhard Sarges、Richard F. Hank、James F. Blake、Jon Bordner、Donald L. Bussolotti、Diane M. Hargrove、Judith L. Treadway、E. Michael Gibbs

  DOI：10.1021/jm950364f

  日期：1996.1.1

  A series of 2-phenoxy-3-phenylpropanoic acids has been prepared which contains many potent hypoglycemic agents as demonstrated by assessing glucose lowering in ob/ob mice. Some compounds (32, 33, 59) normalize plasma glucose in this diabetic model at doses of approximately 1 mg/kg. The mechanism of action of these drugs may involve enhanced glucose transport, especially in fat cells, but the compounds do not stimulate GLUT4 translocation and do not increase the levels of GLUT1 or GLUT4 in vivo. Thus, these compounds may enhance the intrinsic activity of the glucose transporter GLUT1 or GLUT4. Some compounds also modestly decrease hepatocyte gluconeogenesis in vitro, but this is not likely to be a major contributor to the hypoglycemic effect observed in vivo. Likewise, a modest decrease in food consumption observed with some of these compounds was shown by a pair-feeding experiment not to be the primary cause of the hypoglycemia observed.
• US4088474A
  申请人：——

  公开号：US4088474A

  公开（公告）日：1978-05-09
• Thiele; Ahmed; Jahn, Arzneimittel-Forschung/Drug Research, 1979, vol. 29, # 5, p. 711 - 720
  作者：Thiele、Ahmed、Jahn、Adrian

  DOI：——

  日期：——