3,6-二氧杂-4-[(烯丙氧基)甲基]-1,8-辛二醇 | 107106-38-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 中文名称: 3,6-二氧杂-4-[(烯丙氧基)甲基]-1,8-辛二醇
• 英文名称: 3,6-dioxa-4-<(allyloxy)methyl>-1,8-octanediol
• 英文别名: 3,6-dioxa-4-[(allyloxy)methyl]-1,8-octanediol；2-[2-(2-Hydroxyethoxy)-3-prop-2-enoxypropoxy]ethanol
• CAS: 107106-38-7
• 化学式: C₁₀H₂₀O₅
• 分子量: 220.266
• InChiKey: QLNYLJZPTHQVBZ-UHFFFAOYSA-N

物化性质

• 沸点：
  333.4±42.0 °C(Predicted)
• 密度：
  1.084±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  15
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,6-二氧杂-4-[(烯丙氧基)甲基]-1,8-辛二醇 在 正丁基锂 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 38.0h， 生成 5-(Prop-2-enoxymethyl)-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane
  参考文献：
  名称：

  Babb, David A.; Czech, Bronislaw P.; Bartsch, Richard A., Journal of Heterocyclic Chemistry, 1986, vol. 23, p. 609 - 613

  摘要：

  DOI：
• 作为产物：
  描述：

  甘油烯丙基醚 在 lithium aluminium tetrahydride 、 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 22.0h， 生成 3,6-二氧杂-4-[(烯丙氧基)甲基]-1,8-辛二醇
  参考文献：
  名称：

  Babb, David A.; Czech, Bronislaw P.; Bartsch, Richard A., Journal of Heterocyclic Chemistry, 1986, vol. 23, p. 609 - 613

  摘要：

  DOI：

文献信息

• Compositions and methods for selectively binding amines or amino acid enantiomers over their counter-enantiomers
  申请人：IBC Advanced Technologies, Inc.

  公开号：US06686479B2

  公开（公告）日：2004-02-03

  Naphthyl crown ether ligand molecules containing at least two naphthyl groups that are covalently bonded to suitable solid supports and coated by hydrophobic organic solvents are disclosed. These compositions and associated methods are characterized by selectivity of desired amine or amino acid enantiomers over their counter-enantiomers and derivatives. The composition preferably has an &agr;-value greater than or equal to 4. This allows for the separation of such enantiomers with nonchromatographic resin bed separations of three separation stages or less.

  公开了含有至少两个萘基团的萘冠醚配体分子，这些基团与适当的固体支撑物共价结合，并由疏水性有机溶剂包覆。这些组合物和相关方法的特点是对所需胺或氨基酸对映体及其对映体和衍生物的选择性。该组合物的&agr;-值最好大于或等于4。这使得可以通过非色谱树脂床分离三个或更少的分离阶段来分离这些对映体。
• COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES
  申请人：California Institute of Technology

  公开号：US20170049903A1

  公开（公告）日：2017-02-23

  The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

  该发明提供了一种含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还包含一种络合剂。聚合物与络合剂在宿主-客体或客体-宿主相互作用中相互作用，形成包含复合物。该发明的治疗组合物可用于传递治疗剂并治疗各种疾病。颗粒复合物的聚合物和络合剂均可用于向治疗组合物引入功能。该发明还涉及一种制备组合物的方法。该方法将治疗剂、具有宿主或客体功能的聚合物以及具有客体或宿主功能的络合剂结合在一起，形成治疗组合物。络合剂与聚合物形成包含复合物。该发明还涉及一种传递治疗剂的方法。根据该方法，在确实需要治疗的已知需要治疗的哺乳动物（例如人或动物）体内给予该发明的治疗组合物的治疗有效量。还披露了具有以下结构的化合物：
• Complexing agents for compositions containing inclusion complexes
  申请人：Pun Hwang Suzie

  公开号：US20070128167A1

  公开（公告）日：2007-06-07

  The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

  本发明提供了一种含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还包含一个络合剂。聚合物与络合剂通过主-客体或客-主体相互作用形成包含复合物。本发明的治疗组合物可用于输送治疗剂并治疗各种疾病。颗粒复合物的聚合物和络合剂均可用于将功能引入治疗组合物中。本发明还涉及一种制备组合物的方法。该方法将治疗剂、具有主或客体功能的聚合物和具有客体或主体功能的络合剂结合以形成治疗组合物。络合剂与聚合物形成包含复合物。本发明还涉及一种输送治疗剂的方法。根据该方法，将本发明的治疗组合物的治疗有效量注入需要治疗的哺乳动物（例如人或动物）中。还公开了具有以下式的化合物：
• Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network
  申请人：Davis Mark E.

  公开号：US20080279954A1

  公开（公告）日：2008-11-13

  A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the invention is described. A method of treatment by administering a therapeutically effective amount of a supramolecular complex of the invention is also described. Such a supramolecular complex may be used as a delivery vehicle for various therapeutic agents.

  本文描述了一种制备至少含有一种治疗剂和多维聚合物网络的超分子复合物的方法。本发明的方法制备的超分子复合物也被描述了。本文还描述了一种通过给予本发明的超分子复合物治疗有效剂量的方法。这样的超分子复合物可以用作各种治疗剂的传递载体。
• METHOD OF PREPARING A SUPRAMOLECULAR COMPLEX CONTAINING A THERAPEUTIC AGENT AND A MULTI-DIMENSIONAL POLYMER NETWORK
  申请人：Davis Mark E.

  公开号：US20110144190A1

  公开（公告）日：2011-06-16

  A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the invention is described. A method of treatment by administering a therapeutically effective amount of a supramolecular complex of the invention is also described. Such a supramolecular complex may be used as a delivery vehicle for various therapeutic agents.

  本发明涉及一种制备至少含有一种治疗剂和多维聚合物网络的超分子复合物的方法。本发明提出了一种通过本发明方法制备的超分子复合物。本发明还涉及一种通过给予本发明超分子复合物的治疗有效剂量来治疗的方法。这样的超分子复合物可以用作各种治疗剂的输送载体。